Results 111 to 120 of about 22,079 (225)

The cargo receptor SQSTM1 ameliorates neurofibrillary tangle pathology and spreading through selective targeting of pathological MAPT (microtubule associated protein tau)

, 2019
Accumulating evidence suggests that misfolded MAPT (microtubule associated protein tau), the main component of neurofibrillary tangles in tauopathies, is subject to degradation by the autophagy-lysosomal pathway.
Hui Zheng (58412), Sheng Zhang (111330), Yin Xu (159474)   +2 more
core   +1 more source

CSF and plasma lipid profiling predicts risk of cognitive impairment in cognitively unimpaired older adults

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract INTRODUCTION Age‐related cognitive decline and Alzheimer's disease (AD) are strongly influenced by lipid metabolism, yet how central and peripheral lipid profiles relate to disease risk before symptom onset remains unclear. METHODS We performed comprehensive shotgun lipidomics in cerebrospinal fluid (CSF) and plasma from cognitively unimpaired
Takahisa Kanekiyo, Launia J. White, Hongping Ye, Yingxue Ren, Jason D. Ulrich, Ana‐Caroline Raulin, Alla Alnobani, Chengjie Xiong, Yan W. Asmann, Maria Vassilaki, Alicia Algeciras‐Schimnich, Junmin Peng, Fatima S. Amtashar, Suzanne E. Schindler, David M. Holtzman, Guojun Bu, Ronald C. Petersen, Michael G. Heckman, Xianlin Han   +18 more
wiley   +1 more source

MAPT Families Fighting for a Future

Alzheimer's & Dementia
AbstractBackgroundFrontotemporal dementia is the most common form of dementia impacting those under the age of 60. It is estimated that 30% of affected persons have a genetic predisposition to this disease, with mutations in the genes encoding progranulin (GRN), chromosome 9 open reading frame 72(C9orf72), and microtubule associated protein tau (MAPT).
openaire   +1 more source

Phase 3 randomized trial of latozinemab in frontotemporal dementia due to GRN mutations

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract INTRODUCTION Heterozygous progranulin gene mutations causing frontotemporal dementia (FTD‐GRN) are associated with deficiency in progranulin (PGRN). Latozinemab is a human monoclonal immunoglobulin G1 (IgG1) antibody designed to elevate PGRN levels in people with heterozygous loss‐of‐function (LOF) GRN mutations.
Adam Simmons, Bradley Boeve, Isabelle Le Ber, Barbara Borroni, Catherine Mummery, Jonathan D. Rohrer, Giovanna Zamboni, Oezguer A. Onur, James B. Rowe, Adam L. Boxer, Tina Schwabe, Olga I. Kahn, Julie Y. Huang, Hua Long, Ruchi Gupta, Jinglin Zhong, Caiyan Li, Leonard Guizzetti, Lawrence P. Carter, Tuan Nguyen, Tiffany W. Chow, Balasubrahmanyam Budda, Lovingly Park, Sam Jackson, Robert Paul, Michael Ward, Gary Romano, Sara Kenkare‐Mitra, Arnon Rosenthal, Giacomo Salvadore, Arthur J. Mayorga   +30 more
wiley   +1 more source

Brains for dementia research at 18: Commitment to impact the value of human post‐mortem tissue

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract The Brains for Dementia Research (BDR) project was established to provide high quality, neuropathologically characterized post‐mortem brain tissue from a cohort of participants longitudinally assessed for outcomes that are relevant for research in relation to dementia.
Keeley J. Brookes, Nicola Barnett, Johanna S. Jackson, Emma J Kidd, Debra J. Lett, Jillian Madine, Ben Middlehurst, Laura E. Palmer, Laura Parkkinen, Andrew C. Robinson, Rebecca Sims, Lindsey Sinclair, Alexandra Stolzing, Philip Tinkler, Claire Troakes, Lauren Walker, The BDR Collaborative, Alan Thomas, Patrick G. Kehoe   +18 more
wiley   +1 more source

Differential methylation of SNCA and MAPT genes associated with Parkinson’s disease in Mexican Mestizos

Frontiers in Aging Neuroscience
IntroductionParkinson’s disease (PD) is a neurodegenerative disorder characterized by motor symptoms such as bradykinesia, rigidity, and tremor. Despite its prevalence, genetic and epigenetic studies in the Mexican Mestizo population (individuals of ...
Ernesto G. Miranda-Morales, Daniel F. Ramos-Rosales, Alma C. Salas-Leal, Sergio M. Salas-Pacheco, Francisco X. Castellanos-Juárez, Edna M. Méndez-Hernández, Osmel La Llave-León, María S. Peñaherrera, Gerardo Quiñones-Canales, Oscar Arias-Carrión, Oscar Arias-Carrión, Ada A. Sandoval-Carrillo, José M. Salas-Pacheco   +12 more
doaj   +1 more source

Distribution of Big Tau Isoforms in the Human Central and Peripheral Nervous System

Annals of Neurology, Volume 100, Issue 4, Page 709-736, October 2026.
Objective Tau is widely studied in neurodegeneration, yet most work has focused on canonical brain tau isoforms. A longer isoform, “big tau,” produced by inclusion of exon 4a, is expressed in the peripheral nervous system (PNS) and central nervous system (CNS) regions.
Rama Krishna Koppisetti, Nicolas R. Barthélemy, Kanta Horie, Cindy V. Ly, Kaleigh F. Roberts, Srinivas Koutarapu, Richard J. Perrin, Erin E. Franklin, Chiara Pedicone, Joshua Orrick, Justin Melendez, Timothy M. Miller, Chihiro Sato, Nupur Ghoshal, Alison M. Goate, Celeste M. Karch, Randall J. Bateman, Soumya Mukherjee   +17 more
wiley   +1 more source

Unravelling the oncogenic potential and prognostic significance of MAPT in breast cancer: An In-Silico inhibition of MAPT by paclitaxel

Advances in Cancer Biology - Metastasis
Background: Breast cancer is the second top mortality of women globally. A major difficulty in therapeutic therapy is the disease's heterogeneity. However, modern discoveries in molecular biology and immunology have made it possible to create highly focused medicines for a variety of breast tumor subtypes.
Asma Jan, Shazia Sofi, Manzoor Ahmad Mir
openaire   +2 more sources

Progressive Cognitive Decline and Pyramidal Signs in a Patient With a Novel Homozygous c.395A>T; p.Lys132Met Mutation in CHCHD2

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT Biallelic CHCHD2 variants are rare. We report a consanguineous man with a novel homozygous CHCHD2 c.395A>T (p.Lys132Met) variant who developed progressive cognitive decline, apraxia, oculomotor impairment, and pyramidal signs without parkinsonism.
Mehri Salari, Arash Soltani, Masoud Etemadifar, Kamran Rezaei   +3 more
wiley   +1 more source

Changes in Oxidised Phospholipids in Response to Oxidative Stress in Microtubule-Associated Protein Tau (MAPT) Mutant Dopamine Neurons

Antioxidants
Microtubule-associated protein Tau (MAPT) is strongly associated with the development of neurodegenerative diseases. In addition to driving the formation of neurofibrillary tangles (NFT), mutations in the MAPT gene can also cause oxidative stress through
Xanthe Bradford, Hugo J. R. Fernandes, Stuart G. Snowden   +2 more
doaj   +1 more source