Results 111 to 120 of about 20,159 (186)

Plasma Proteomic Changes in GRN and C9orf72 Frontotemporal Dementia

European Journal of Neurology, Volume 33, Issue 7, July 2026.
Multiplex plasma profiling of 124 CNS‐related proteins in genetic frontotemporal dementia (FTD) identified NfL and NfH as the most consistently altered biomarkers in both GRN‐ and C9orf72‐associated disease. Distinct protein changes emerged across genotypes, including changes in GFAP and VCAM1 in GRN‐FTD, and reduced NPTXR as well as nominally altered ...
Joel Simrén, Andrea L. Benedet, Guglielmo Di Molfetta, Ilaria Pola, Kübra Tan, Valentina Cantoni, Ilenia Libri, Jasmine Rivolta, Roberta Ghidoni, Henrik Zetterberg, Barbara Borroni, Nicholas J. Ashton   +11 more
wiley   +1 more source

Phase Separation Drives Pathological Aggregation in Neurodegenerative Diseases: A 15‐Year Bibliometric Landscape (2009–2024)

Annals of the New York Academy of Sciences, Volume 1561, Issue 1, July 2026.
This 15‐year bibliometric study (2009–2024) characterizes the global landscape of liquid–liquid phase separation (LLPS) in neurodegenerative diseases. We delineate the field's evolution from fundamental biophysics to clinical translation, emphasizing the liquid‐to‐solid transition of proteins like TDP‐43, tau, and α‐synuclein.
Chanyuan Zhang, Siyao Chen, He Zhao, Yan Wang, Lingyan Zhou, Haixia Fan, Yan Sun   +6 more
wiley   +1 more source

Changes in Oxidised Phospholipids in Response to Oxidative Stress in Microtubule-Associated Protein Tau (MAPT) Mutant Dopamine Neurons

Antioxidants
Microtubule-associated protein Tau (MAPT) is strongly associated with the development of neurodegenerative diseases. In addition to driving the formation of neurofibrillary tangles (NFT), mutations in the MAPT gene can also cause oxidative stress through
Xanthe Bradford, Hugo J. R. Fernandes, Stuart G. Snowden   +2 more
doaj   +1 more source

Epigénomique du gène MAPT dans les tauopathies [PDF]

, 2016
Tauopathies are neurodegenerative diseases characterized by intracerebral aggregation of abnormal tau proteins. However, these diseases are heterogeneous clinically, pathologically but also biochemically with the aggregation of different isoforms of tau ...
Huin, Vincent
core  

MAPT p.V363I mutation: A rare cause of corticobasal degeneration [PDF]

, 2019
Objective: Patients with corticobasal syndrome (CBS) present with heterogeneous clinical features, including asymmetric parkinsonism, dyspraxia, aphasia, and cognitive impairment; to better understand the genetic etiology of this rare disease, we ...
Pastor, P, Gasser, T, Gelpi, E, Pantelyat, A, Ahmed, S, Ding, J, Jabbari, E, Morris, CM, Morris, HR, Scholz, SW, Troncoso, J, Fairen, MD, Ispierto, L, Schulte, C, Sabir, MS, Butala, A, Pletnikova, O   +16 more
core  

Analysis of MAPT on Alzheimer’s Disease [PDF]

Alzheimer’s is the 7 th most common cause for death in humans and unfortunately has no cure. Coincidentally the gene MAPT (microtubule-associated protein tau) increases chances of obtaining Alzheimer\u27s.
Vanterpool, Elaine, Morgan, Marc, Jr.
core   +1 more source

Nimodipine Improves Cognitive Impairment After Subarachnoid Hemorrhage in Rats Through IncRNA NEAT1/miR-27a/MAPT Axis

Drug Design, Development and Therapy, 2020
Jun-Wei Li, Shao-Hua Ren, Jin-Rui Ren, Zi-Gang Zhen, Li-Rong Li, Xu-Dong Hao, Hong-Ming Ji Department of Neurosurgery, The People’s Hospital of Shanxi Province, Taiyuan, Shanxi Province, People’s Republic of ChinaCorrespondence: Hong-Ming Ji ...
Li JW, Ren SH, Ren JR, Zhen ZG, Li LR, Hao XD, Ji HM   +6 more
doaj  

A novel MAPT variant (E342K) as a cause of familial progressive supranuclear palsy

Frontiers in Neurology
BackgroundMAPT variants are a known cause of frontotemporal dementia and Parkinsonian syndrome, of which progressive supranuclear palsy syndrome (PSP) is a rare manifestation.ObjectiveTo report a novel MAPT variant in a PSP pedigree with autosomal ...
Hang Li, Qijun Li, Qijun Li, Qin Weng, Ruixue Cui, Ruixue Cui, Tzu-Chen Yen, Yanfeng Li   +7 more
doaj   +1 more source

The MIR-NAT MAPT-AS1 does not regulate Tau expression in human neurons [PDF]

The MAPT gene encodes Tau protein, a member of the large family of microtubuleassociated proteins. Tau forms large insoluble aggregates that are toxic to neurons in several neurological disorders, and neurofibrillary Tau tangles represent a key ...
De Strooper, Bart, Martinez-Montero, Saul, Vandermeulen, Lina, d'Ydewalle, Constantin, Wolfs, Leen, Royaux, Ines, Sierksma, Annerieke, Mestdagh, Pieter, Policarpo, Rafaela, Van Peer, Gert   +9 more
core  

Multi-omic phenotyping of MAPT V337M neurons reveals early changes in axonogenesis and tau phosphorylation. [PDF]

NPJ Dement
Mohl GA, Dixon G, Marzette E, McKetney J, Samelson AJ, Serras CP, Jin J, Ariqat N, Keys A, Chavira C, Li A, Boggess SC, Swaney DL, Kampmann M.   +13 more
europepmc   +1 more source