Results 121 to 130 of about 22,079 (225)

Cross‐cohort NULISAseq identifies tau‐anchored CSF and plasma‐specific signatures across the amyloid‐positive Alzheimer's disease [PDF]

Alzheimers Dement
Abstract INTRODUCTION ATN‐stratified cerebrospinal fluid (CSF) proteomic signals may partly reflect classifier tau immunoassays; reproducible non‐tau signals and CSF–plasma differences remain unclear. METHODS We profiled CSF from 60 A+ Beijing patients with Alzheimer's disease (AD) and 875 A+ Alzheimer's Disease Neuroimaging Initiative (ADNI ...
Ding L, Zheng M, Wang S, Liu W, Liang Y, Xie S, Yang T, Sheng D, Wang S, Sheng J, Jia J.   +10 more
europepmc   +2 more sources

Haplotypes and Gene Expression Implicate the Mapt Region for Parkinson Disease: the GenePD Study

, 2008
Background: Microtubule-associated protein tau (MAPT) has been associated with several neurodegenerative disorders including forms of parkinsonism and Parkinson disease (PD).
al., et, Singer, C., Pezzoli, G., Golbe, L. I., Lew, M. F., Wooten, G. F., Latourelle, J. C., Goldwurm, S., Mark, M. H., Shill, Holly A., Suchowersky, O., Baker, K. B., Klein, C., Watts, R., Perlmutter, J. S., Guttman, M., Growdon, J. H., Racette, B. A., Saint-Hilaire, M. H., Tobin, J. E.   +19 more
core   +1 more source

Stem Cell and EV/sEV Strategies for Neuroimmune Niche Reprogramming in Selected CNS Disorders: Mechanisms, Engineered Delivery, and Translational Readiness

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
Stem cell‐ and EV/sEV‐based interventions may reprogram the CNS neuroimmune niche by suppressing glial inflammation, enhancing trophic and synaptic support, stabilizing BBB communication, and improving metabolic resilience. Clinical translation will require mechanism‐linked potency assays, MISEV‐aligned EV reporting, biodistribution, GMP manufacturing,
Wenjing Lu, Junqiang Yan, Hongfang Feng
wiley   +1 more source

Human biomarker navigator

iMeta, Volume 5, Issue 5, October 2026.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Cytoskeletal Dynamics in Cancer: From Pathogenesis to Treatment

MedComm, Volume 7, Issue 10, October 2026.
This review systematically addresses the fundamental roles of the cytoskeleton (actin filaments, microtubules, and intermediate filaments) in cancer progression. We focus on how cytoskeletal dynamics regulate tumor proliferation, metastasis, and programmed cell death, while also modulating the immune microenvironment. Understanding these mechanisms may
Jie Chen, Wenxi Yang, Yonghan Song, Yuanhao Zhang, Jia Ma, Tingyao Wang, Jijun Zheng, Hebin Zhang, Yiyao Liu, Jinhao Zeng   +9 more
wiley   +1 more source

Myelin Impairment and Regeneration in the Central Nervous System: Molecular Mechanisms, Diseases, and Prospective Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
Proper myelin formation is crucial for normal neural circuit function, while myelin deficiency can lead to neural circuit dysfunction and cognitive decline, notably in Alzheimer's disease and other central nervous system demyelinating disorders. This review summarizes central myelin's structure and function, demyelination biomarkers and pathological ...
Lihong Huang, Peng Cheng, Guangdong Liu, Yang Xiang, Zhen Hong, Weidong Le   +5 more
wiley   +1 more source

Haplotypes and gene expression implicate the MAPT region for Parkinson disease - The GenePD Study

Background: Microtubule-associated protein tau ( MAPT) has been associated with several neurode-generative disorders including forms of parkinsonism and Parkinson disease (PD).
Singer C, Al-Hinti J, Drasby E, Massood T, Nagle MW, Roxburgh R, Wilk JB, Laramie JM, Lew MF, Latourelle JC, Wooten GF, Mark MH, Litvan I, Hendricks AE, Corbett A, Pramstaller PP, Isaacson S, Baker KB, Nicholson G, Shill HA, Growdon JH, Myers RH, Sherman S, Snow B, Slevin JT, Nance M, Goldwurm S, Moller AT, Tobin JE, Williamson S, Watts R, Chinnery PF, Ostergaard K, Cambi F, Racette BA, Burn DJ, Guttman M, Gusella JF, Pezzoli G, Klein C, Golbe LI, Perlmutter JS, DeStefano AL, Saint-Hilaire MH, Suchowersky O   +44 more
core   +4 more sources

Structure of the MAPT gene and protein.

, 2018
Alternative splicing of MAPT produces six canonical isoforms. grey = constitutive exons, white = not expressed in human central nervous system.
Towfique Raj (170931), Mary E. Fowkes (5082083), John F. Crary (507159), Marco M. Hefti (276488), Kurt Farrell (5082077), SoongHo Kim (5082080), Kathryn R. Bowles (836917)   +6 more
core   +1 more source

Progressive Supranuclear Palsy in India: Insights from a Large Multicenter Clinical Cohort (Project PAIR‐PSP)

Movement Disorders Clinical Practice, Volume 13, Issue 10, Page 2439-2452, October 2026.
Background Progressive supranuclear palsy (PSP) is a rare and devastating tauopathy with limited global data. Given India's large population, genetic diversity, and clinical heterogeneity, large multicenter datasets are crucial to enrich global understanding of PSP. Objective To characterize the demographic, clinical, and phenotypic profiles of a large
Prashanth Lingappa Kukkle, Divyani Garg, Jacky Ganguly, Soaham Desai, Rukmini Mridula Kandadai, Sahil Mehta, Pettarusp Murzban Wadia, Deepika Joshi, Lulup Sahoo, Vijayashankar Paramanandam, Taallapalli Ashok Vardhan Reddy, Adreesh Mukherjee, Syam Krishnan, Kuldeep Shetty, Charulata Sankhla, Pankaj Agarwal, Heli S. Shah, Suvorit Bhowmick, Mitesh Chandarana, Malini Venkata, Thenral S. Geetha, Ramesh Menon, Sandeep Charugulla, Sakthivel Murugan, Ravi Gupta, Niraj Kumar, Atanu Biswas, Hrishikesh Kumar, Rupam Borgohain, Huw Morris, Vedam. L Ramprasad, Parkinson's Research Alliance of India (PRAI) and the Global Parkinson's Genetic Program (GP2)   +31 more
wiley   +1 more source

Therapeutic intervention strategies in frontotemporal dementia: drug development pipeline

Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 4, October/December 2026.
Abstract Frontotemporal dementia (FTD) is the second most common cause of early‐onset dementia after Alzheimer's disease, characterized by substantial genetic, clinical, and pathological heterogeneity. Despite progress in understanding its pathophysiology, no disease‐targeted therapies (DTTs) have been approved to date.
Federica Perrone, Nicoletta Locuratolo, Elena Carbone, Marisa Cappella, Roberto Rivabene, Elisa Fabrizi, Giuseppina Talarico, Nicola Vanacore, Eleonora Lacorte, Paola Piscopo   +9 more
wiley   +1 more source