Results 131 to 140 of about 22,079 (225)

Frontotemporal lobar degeneration therapeutic development pipeline: 2026

Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 4, October/December 2026.
Abstract INTRODUCTION Frontotemporal lobar degeneration (FTLD) comprises a group of neuropathological entities underlying a spectrum of clinical syndromes, including behavioral variant frontotemporal dementia, the primary progressive aphasias, progressive supranuclear palsy, and corticobasal syndrome.
Alberto Benussi, Aurora Saccavini, Federica Palacino, Bradley F. Boeve, Adam L. Boxer, Edward D. Huey, Isabelle Le Ber, Raffaella L. Migliaccio, Chiadi U. Onyike, Olivier Piguet, Yolande A. L. Pijnenburg, Jonathan D. Rohrer, James B. Rowe, Eino Solje, Markus Otto, Barbara Borroni, Jeffrey L. Cummings   +16 more
wiley   +1 more source

Clinical and genetic analysis of MAPT, GRN, and C9orf72 genes in Korean patients with frontotemporal dementia

, 2018
C9orf72; Frontotemporal dementia; GRN; Korean; MAPT ...
정지향
core   +1 more source

Genome‐Wide Association Studies of Hospitalized Influenza Identify Four Risk Loci and Reveal Shared and Unique Genetic Factors Compared With COVID‐19

Influenza and Other Respiratory Viruses, Volume 20, Issue 10, October 2026.
ABSTRACT Background Influenza remains a significant global health burden, potentially leading to hospitalization and mortality. Although previous studies have explored genetic susceptibility to influenza infection, the genetic basis of influenza hospitalization and its relationship with respiratory diseases like COVID‐19 remain poorly understood ...
Xiao Xue, Yaning Feng, Yu‐Ping Lin, Pui‐Ching Chan, Hon‐Cheong So   +4 more
wiley   +1 more source

CTE MAPT subhaplotypes

Structural haplotypes in the 17q21.31 MAPT region and Chronic Traumatic Encephalopathy ...
Xudong Han
core  

Characterization of the brain lipidome associated with frontotemporal lobar degeneration MAPT P301S mutation

Journal of Lipid Research
Mutations in microtubule-associated protein Tau (MAPT), the gene that codes for the protein Tau, cause frontotemporal lobar degeneration (FTLD) with phenotypes ranging from behavioral changes to cognitive impairment and parkinsonism.
Almudena Maroto-Juanes, Thomas Vogels, Sascha Koppes-den Hertog, Maarten Loos, Dieter Lütjohann, Martin Giera, Rik van der Kant   +6 more
doaj   +1 more source

MAPT Gene [PDF]

, 2020
openaire   +1 more source

MAPT p.V363I mutation: A rare cause of corticobasal degeneration [PDF]

, 2019
Objective: Patients with corticobasal syndrome (CBS) present with heterogeneous clinical features, including asymmetric parkinsonism, dyspraxia, aphasia, and cognitive impairment; to better understand the genetic etiology of this rare disease, we ...
Pastor, P, Gasser, T, Gelpi, E, Pantelyat, A, Ahmed, S, Ding, J, Jabbari, E, Morris, CM, Morris, HR, Scholz, SW, Troncoso, J, Fairen, MD, Ispierto, L, Schulte, C, Sabir, MS, Butala, A, Pletnikova, O   +16 more
core   +1 more source

Nimodipine Improves Cognitive Impairment After Subarachnoid Hemorrhage in Rats Through IncRNA NEAT1/miR-27a/MAPT Axis

Drug Design, Development and Therapy, 2020
Jun-Wei Li, Shao-Hua Ren, Jin-Rui Ren, Zi-Gang Zhen, Li-Rong Li, Xu-Dong Hao, Hong-Ming Ji Department of Neurosurgery, The People’s Hospital of Shanxi Province, Taiyuan, Shanxi Province, People’s Republic of ChinaCorrespondence: Hong-Ming Ji ...
Li JW, Ren SH, Ren JR, Zhen ZG, Li LR, Hao XD, Ji HM   +6 more
doaj  

A novel MAPT variant (E342K) as a cause of familial progressive supranuclear palsy

Frontiers in Neurology
BackgroundMAPT variants are a known cause of frontotemporal dementia and Parkinsonian syndrome, of which progressive supranuclear palsy syndrome (PSP) is a rare manifestation.ObjectiveTo report a novel MAPT variant in a PSP pedigree with autosomal ...
Hang Li, Qijun Li, Qijun Li, Qin Weng, Ruixue Cui, Ruixue Cui, Tzu-Chen Yen, Yanfeng Li   +7 more
doaj   +1 more source

MAPT Subhaplotypes in Different Progressive Supranuclear Palsy Phenotypes

Biomedicines
Background: Progressive Supranuclear Palsy (PSP) is a rare neurodegenerative disorder characterized by abnormal tau protein aggregation. The MAPT gene encodes for tau protein.
Monica Gagliardi, Radha Procopio, Alessia Felicetti, Grazia Annesi, Mariagrazia Talarico, Basilio Vescio, Aldo Quattrone, Andrea Quattrone   +7 more
doaj   +1 more source