Results 101 to 110 of about 20,159 (186)
Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.Abstract INTRODUCTION Neurodegenerative diseases often involve overlapping alpha‐synuclein (asyn), amyloid beta, and tau proteinopathies, yet the mechanisms, impact, and directionality of their interactions remain unclear. METHODS We induced brain‐wide neuronal asyn/tau pathologies via viral expression of wild‐type asyn, mutant asynE46K, mutant ...
Benjamin E. Rabichow +7 more
wiley +1 more source
LTP data from MAPT-AD experiment and APP/PS1 experiment [PDF]
, 2018 The repository contains data from electrophysiology recordings from hippocampal brain slices to measure long term potentiation. The data contain experiments from 2 experiment. LTP_MAPTAD contains data from the following genotypes: - MAPT-null - MAPT-null
Oren, Iris +5 more
core +1 more source
乳腺癌生存期相关长非编码 MAPT-AS1 及其共表达基因筛选与验证
Zhongshan Daxue xuebao. Yixue kexue ban, 2019 【目的】筛选乳腺癌患者生存期相关差异表达长链非编码RNA（lncRNA）及其共表达基因，并验证其乳腺癌细胞中的表达情况。【方法】通过TCGA数据库筛选943例RNA-seq数据信息：（837例乳腺癌患者+106例正常对照），发现长非编码MAPT-AS1高表达，乳腺癌患者生存期更长。构建长非编码MAPT-AS1过表达和干扰质粒，将构建好的质粒转染乳腺癌细胞株T47D，并用嘌呤霉素筛选出稳定表达的T47D细胞株，通过RT-qPCR验证长非编码MAPT-AS1及其共表达基因的表达情况。【结果 ...
许家瑞 +6 more
doaj
Frontiers in Aging NeuroscienceIntroductionParkinson’s disease (PD) is a neurodegenerative disorder characterized by motor symptoms such as bradykinesia, rigidity, and tremor. Despite its prevalence, genetic and epigenetic studies in the Mexican Mestizo population (individuals of ...
Ernesto G. Miranda-Morales +12 more
doaj +1 more source
BMC Neurology, 2017 Background Frontotemporal degeneration (FTD) is a clinically and genetically heterogeneous neurodegenerative disorder characterized by deficits in executive function that frequently overlaps with parkinsonism and motor neuron disorders.
Hui-Chi Lin +4 more
doaj +1 more source
Salivary Extracellular Vesicles: Paradigm Shift in Liquid Biopsy Diagnostics
Journal of Extracellular Biology, Volume 5, Issue 7, July 2026.ABSTRACT Extracellular vesicles (EVs), lipid bilayer nanoparticles released by virtually all cells, serve as essential messengers for intercellular communication. Due to their involvement in several pathophysiological processes, EVs have recently gained considerable attention as potentially diagnostic and prognostic biomarkers for various illnesses ...
Kwanele Xulu +3 more
wiley +1 more source
Structural haplotypes in the 17q21.31 MAPT region and Chronic Traumatic Encephalopathy ...
Xudong Han
core
The role of MAPT sequence variation in mechanisms of disease susceptibility. [PDF]
, 2012 The microtubule-associated protein tau (MAPT or tau) is of great interest in the field of neurodegeneration as there is a well-established genetic link between the MAPT gene locus and tauopathies, a diverse group of neurodegenerative dementias and ...
Caffrey, Tara +3 more
core +1 more source
Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 3, July/September 2026.Abstract The Second International Conference on Unconventional Animal Models of Alzheimer's Disease and Aging (UAMAA 2026) was held February 9 through 11, 2026, in Irvine, California. Building upon the inaugural meeting in Santiago, Chile (2023), this conference expanded an international effort to develop, characterize, and rigorously evaluate non ...
Jane Alshami +6 more
wiley +1 more source
Haplotype-specific expression of exon 10 at the human MAPT locus [PDF]
, 2006 Neurofibrillary tangles composed of exon 10+ microtubule associated protein tau (MAPT) deposits are the characteristic feature of the neurodegenerative diseases progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD).
Caffrey, Tara M. +11 more
core +2 more sources