Results 191 to 200 of about 98,352 (316)

SKALE: An Interpretable Multiscale Machine Learning Model for Decoding Phase‐Specific Protein Aggregation in Neurodegenerative Proteinopathies

open access: yesAggregate, Volume 7, Issue 2, February 2026.
Protein aggregation drives diverse degenerative diseases, yet its molecular origins are difficult to predict. SKALE uses interpretable machine learning to link sequence, structure, and dynamics, revealing how local structural weakening triggers aggregation.
Wei Xuan Wilson Loo   +7 more
wiley   +1 more source

APOE4 and cognition in intracranial atherosclerosis: beyond Alzheimer's pathology

open access: yesAlzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION The apolipoprotein E ε4 (APOE ε4) allele is a major genetic risk factor for Alzheimer's disease, but its relevance to cognition in intracranial atherosclerosis (ICAS) remains unclear. We investigated the association between APOE ε4 and cognition in ICAS. METHODS Baseline data from a multicenter cohort were analyzed.
Anqi Cheng   +14 more
wiley   +1 more source

Association between brain volume and depression in Alzheimer's disease: Neuroimaging insights

open access: yesAlzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Alzheimer's disease (AD) often co‐occurs with depression, affecting cognitive function and quality of life. Understanding the neurobiological links between brain abnormalities and depressive symptoms is essential for effective treatment.
Chao Tang   +6 more
wiley   +1 more source

Neurogenesis and the Epigenetic Landscape: Role of Histone Modifications and Chromatin Remodeling

open access: yesBrain and Behavior, Volume 16, Issue 2, February 2026.
Histone methylation and acetylation modulate gene expression by inducing chromatin condensation or relaxation, which in turn regulates transcriptional activity and impacts neurogenesis. ABSTRACT Aims The purpose of this review is to examine how epigenetic regulation particularly chromatin modification and histone methylation controls gene expression ...
Degisew Yinur Mengistu   +1 more
wiley   +1 more source

P3‐212: Patterns of brain atrophy in frontotemporal dementia with mutations in MAPT or PGRN [PDF]

open access: bronze, 2009
Jennifer L. Whitwell   +10 more
openalex   +1 more source

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