Results 191 to 200 of about 53,213 (267)

Blood‐based Alzheimer's disease biomarkers in a behavioral neurology clinic: Real‐world implementation, clinical utility, and diagnostic performance

Alzheimer's &Dementia, Volume 21, Issue 11, November 2025.
Abstract INTRODUCTION Blood‐based biomarkers (BBMs) for Alzheimer's disease (AD), including plasma phosphorylated tau (p‐tau), are increasingly used in clinical practice, but “real‐world” implementation patterns, context‐of‐use (COU), clinical utility, and diagnostic performance are incompletely understood. METHODS A retrospective analysis of the first
Igor Prufer Q C Araujo, Tara Ellingson, Nicholas U. Schwartz, Connor D. Dietz, Gautam Tammewar, Kaancan Deniz, Manizhe Eslami‐Amirabadi, Andrew G. Breithaupt, Marci Rosenberg, Nhat Minh Bui, Yasmeen Gonzalez, Renaud La Joie, Peter A. Ljubenkov, Katherine L. Possin, Julio C. Rojas, David N. Soleimani‐Meigooni, Yingbing Wang, Adam M. Staffaroni, Melanie L. Stephens, Elena Tsoy, Charles C. Windon, Adam L. Boxer, Gil D. Rabinovici, Bruce L. Miller, Lawren VandeVrede   +24 more
wiley   +1 more source

Longitudinal plasma proteomics: relation to incident Alzheimer's disease dementia and biomarkers

Alzheimer's &Dementia, Volume 21, Issue 11, November 2025.
Abstract INTRODUCTION We investigated whether longitudinal changes in plasma proteins were associated with baseline cognitive stages related to Alzheimer's disease (AD), their progression, and AD biomarkers. METHODS We analyzed longitudinal proteomics (SomaScan 7K) data (N = 347) from the Indiana AD Research Center using linear mixed‐effects models for
Eun Hye Lee, Yen‐Ning Huang, Tamina Park, Shiwei Liu, Nicholas Adzibolosu, Soumilee Chaudhuri, Changgee Chang, Paula J. Bice, Jeffrey L. Dage, Jared R. Brosch, Sujuan Gao, Liana G. Apostolova, Donna M. Wilcock, Shannon L. Risacher, Andrew J. Saykin, Taeho Jo, Kwangsik Nho   +16 more
wiley   +1 more source

Thalamus involvement in genetic frontotemporal dementia assessed using structural and diffusion MRI: a GENFI study. [PDF]

Brain Commun
Soskic S, Tregidgo HFJ, Todd EG, Bouzigues A, Cash DM, Russell LL, Thomas DL, Malone IB, Foster PH, Ferry-Bolder E, van Swieten JC, Jiskoot LC, Seelaar H, Sanchez-Valle R, Laforce R, Graff C, Galimberti D, Vandenberghe R, de Mendonça A, Tiraboschi P, Santana I, Gerhard A, Levin J, Nacmias B, Otto M, Bertoux M, Lebouvier T, Ducharme S, Butler CR, Le Ber I, Finger EC, Tartaglia MC, Masellis M, Rowe JB, Synofzik M, Moreno F, Borroni B, Alexander DC, Iglesias JE, Rohrer JD, Bocchetta M, GENetic Frontotemporal dementia Initiative (GENFI) .   +41 more
europepmc   +1 more source

Dementia Data Landscape 1. Cohorts

Alzheimer's &Dementia, Volume 21, Issue 11, November 2025.
Abstract INTRODUCTION Understanding and maximizing complex health data is crucial for accelerating discovery, translational research, funding priorities, and improving data management. Rapid, cost‐effective progress can be made by repurposing datasets. This work explores the dementia cohort landscape, identifies cohorts relevant to dementia translation,
Amelia Morgan, Conor Durkin, Benjamin Tari, Emma Squires, Simon Young, Joshua Bauermeister, Sarah Bauermeister, John Gallacher   +7 more
wiley   +1 more source

Involvement of cerebellum in frontotemporal dementia; a case presentation using fluorodeoxyglucose positron emission tomography/magnetic resonance imaging (FDG-PET/MRI)

, 2019
Samson Nivins, Samuel Berkins
openalex   +1 more source

Neuroinflammatory mechanisms linking high‐fat diets to Alzheimer's disease vulnerability: Beyond the amyloid hypothesis

Alzheimer's &Dementia, Volume 21, Issue 11, November 2025.
Abstract As global life expectancy increases, Alzheimer's disease (AD) incidence is rising rapidly. While research has long focused on amyloid beta (Aβ) and tau pathology, recent controversies and limited clinical success of Aβ‐targeting therapies have challenged their centrality in AD.
Sabrina E. Mackey‐Alfonso, Ruth M. Barrientos   +1 more
wiley   +1 more source

Thyroid Cancer Surgery in a Patient With Frontotemporal Dementia: Balancing Oncologic and Neurocognitive Challenges. [PDF]

Cureus
Bontozis A, Makris A, Tzanakis N, Politopoulos C, Giannopoulos G.   +4 more
europepmc   +1 more source

Human microglia differentially respond to β‐amyloid, tau, and combined Alzheimer's disease pathologies in vivo

Alzheimer's &Dementia, Volume 21, Issue 11, November 2025.
Abstract INTRODUCTION Recent studies have identified important species‐dependent differences in the response of microglia to β‐amyloid (Aβ) pathology. Yet, whether human microglia also interact differently with the pathognomonic combination of amyloid and tau pathologies that occur in Alzheimer's disease (AD) remains unclear.
Morgan A. Coburn, Ghazaleh Eskandari‐Sedighi, Jonathan Hasselmann, Whitney England, Sepideh Kiani Shabestari, Kimiya Mansour, Amanda McQuade, Michael Armen Mgerian, Jean Paul Chadarevian, Christina Tu, Jorge Silva, Jaclyn Beck, Zahara Keulen, Robert C. Spitale, Hayk Davtyan, Mathew Blurton‐Jones   +15 more
wiley   +1 more source