Results 211 to 220 of about 98,352 (316)

White matter hyperintensities precede other biomarkers in GRN frontotemporal dementia [PDF]

open access: gold
Soltaninejad, Mahdie   +38 more
openalex  

Hereditary Frontotemporal Dementia Caused by Tau Gene Mutations

open access: green, 2007
John C. van Swieten   +1 more
openalex   +2 more sources

Serum neurofilament light chain in behavioral variant frontotemporal dementia [PDF]

open access: bronze, 2018
Petra Steinacker   +52 more
openalex   +1 more source

A complex network perspective on brain disease

open access: yesBiological Reviews, Volume 101, Issue 1, Page 364-399, February 2026.
ABSTRACT If brain anatomy and dynamics have a complex network structure as it has become standard to posit, it is reasonable to assume that such a structure should play a key role not only in brain function but also in brain dysfunction. However, exactly how network structure is implicated in brain damage and whether at least some pathologies can be ...
David Papo, Javier M. Buldú
wiley   +1 more source

Prevalence and Modifiable Risk Factors of Dementia in People With Down Syndrome: Cross‐Sectional Study of Japan in Collaboration With the Intellectual Diversity for Goodness Research Consortium (INDIGO‐2019)

open access: yesJournal of Intellectual Disability Research, Volume 70, Issue 3, Page 329-336, March 2026.
ABSTRACT Background People with Down syndrome (DS) have a strong genetic predisposition to Alzheimer's disease (AD). However, the clinical burden and associated risk factors in diverse, non‐Western populations remain less understood. This study aimed to investigate the prevalence of dementia in Japanese adults with DS and to identify modifiable ...
Shintaro Takenoshita   +6 more
wiley   +1 more source

Analyses of the Effects of Wild‐Type TDP‐43 Overexpression in Oxytocin Neurons in Mice

open access: yesNeuropathology and Applied Neurobiology, Volume 52, Issue 1, February 2026.
ABSTRACT Selective TDP‐43 overexpression in oxytocin neurons in the paraventricular nucleus of the hypothalamus causes a decrease in oxytocin‐immunopositive cells compared to uninjected mice. AAV‐mediated TDP‐43 overexpression in oxytocin neurons does not appear to be a major driver of behavioural and metabolic phenotypes in mice.
Sofia Bergh   +2 more
wiley   +1 more source

Pleiotrophin/Midkine Pathway Is Dysregulated in a TDP‐43A315T Mouse Model of Amyotrophic Lateral Sclerosis (ALS)

open access: yesNeuropathology, Volume 46, Issue 1, February 2026.
ABSTRACT Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease (MND) characterized by progressive degeneration of both upper and lower motor neurons, along with skeletal muscles innervated by them. The identification of key molecules involved in disease pathology remains crucial for ALS, as no curative treatment is currently available ...
Paloma Martínez‐Alesón   +3 more
wiley   +1 more source

Defining the Intestinal eCBome and Oxylipin Signaling Systems in a TDP‐43 Mouse Model of Frontotemporal Dementia

open access: yesThe FASEB Journal, Volume 40, Issue 2, 31 January 2026.
TDP‐43 overexpressing mice, a genetic model of frontotemporal dementia, exhibit dramatic changes in their small intestinal endocannabinoidome members, in terms of both altered concentrations of lipid mediators and expression of some of their receptors (Cnr1, Gpr119, Gpr55, Pparg) and metabolic enzymes (Napepld, Faah). Also, the levels of some oxylipins
Hayatte‐Dounia Mir   +9 more
wiley   +1 more source

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