Results 221 to 230 of about 315,827 (302)

Proteostasis of organelles in aging and disease

The FEBS Journal, Volume 293, Issue 18, Page 5600-5626, September 2026.
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu, David Vilchez   +5 more
wiley   +1 more source

Stimulating proteasomal degradation in human proteinopathies

The FEBS Journal, Volume 293, Issue 18, Page 5514-5540, September 2026.
The proteasome mediates the degradation of a wide range of proteins. Boosting proteasomal degradation may be beneficial in several disease contexts and can be achieved either by modulating proteasome activity or by improving substrate delivery. Proteasome activity can be enhanced by increasing proteasome abundance, inducing constitutive gate opening ...
Maria E. Gierisch, Enrica Barchi, Nico P. Dantuma   +2 more
wiley   +1 more source

Frontotemporal dementia: does structural MRI-based clustering match clinical syndromes? [PDF]

Front Neurosci
Singh-Reilly N, Sintini I, Ali F, Duffy JR, Clark HM, Utianski RL, Meade G, Machulda MM, Satoh R, Lowe VJ, Josephs KA, Whitwell JL.   +11 more
europepmc   +1 more source

Differential aspects of familiar people recognition disorders in right and left variants of semantic dementia: A critical review

Journal of Neuropsychology, Volume 20, Issue 3, Page 647-658, September 2026.
Abstract The aim of the present review will consist of discussing the different forms of familiar people recognition disorders observed in the right and left variants of semantic dementia. The review will start with a summary of the main cognitive models of familiar people recognition and of the neuroanatomical correlates of the processing stages ...
Guido Gainotti
wiley   +1 more source

Validation of the German version of the Dimensional Apathy Scale (G‐DAS): Application in amyotrophic lateral sclerosis

Journal of Neuropsychology, Volume 20, Issue 3, Page 702-712, September 2026.
Abstract Apathy is a common behavioural impairment in neurodegenerative conditions and is conceptualized within the Dimensional Apathy Framework as comprising Executive, Emotional and Initiation subtypes. The Dimensional Apathy Scale (DAS) is widely used to assess these domains, yet no validated German version has been available.
Judith Wesenberg, Paula Matthies, Kati Schwiecker, Verena Bittner, Samra Hamzic, Stefan Vielhaber, Ratko Radakovic   +6 more
wiley   +1 more source

Diagnosis of Frontotemporal Dementia in Individuals With Late-Onset Behavioral Changes: Importance of Genetic Counseling. [PDF]

Neurol Genet
Irwin DJ.
europepmc   +1 more source

Talking therapies for anxiety and depression in people affected by dementia: A scoping meta‐review

Psychology and Psychotherapy: Theory, Research and Practice, Volume 99, Issue 3, Page 870-890, September 2026.
Abstract Background Symptoms of anxiety and depression are common in people affected by dementia (people with dementia and family carers). There are many reviews of psychological interventions to reduce stress and distress in people with dementia and family carers, but little cross‐fertilisation with the evidence base underpinning NHS Talking Therapies
Georgina Charlesworth, Cassie Eastham, Lydia Morris   +2 more
wiley   +1 more source

Glutamatergic neuron degeneration in <i>C. elegans</i> models of Frontotemporal Dementia and Amyotrophic Lateral Sclerosis. [PDF]

MicroPubl Biol
Hassell LA, Gallati M, Thoma M, Asfaw S, Hart AC.   +4 more
europepmc   +1 more source