Results 31 to 40 of about 364,393 (335)

Truncated stathmin-2 is a marker of TDP-43 pathology in frontotemporal dementia.

Journal of Clinical Investigation, 2020
No treatment for frontotemporal dementia (FTD), the second most common early-onset dementia, is available but therapeutics are being investigated to target the two main proteins associated with FTD pathological subtypes: TDP-43 (FTLD-TDP) and tau (FTLD ...
M. Prudencio, J. Humphrey, Sarah R Pickles, Anna L. Brown, Sarah E. Hill, J. Kachergus, Ji Shi, M. Heckman, Matthew R. Spiegel, C. Cook, Yuping Song, Mei Yue, Lillian M. Daughrity, Y. Carlomagno, Karen R. Jansen-West, Cristhoper H. Fernandez De Castro, M. DeTure, S. Koga, Ying-Chih Wang, P. Sivakumar, C. Bodo, A. Candalija, K. Talbot, B. Selvaraj, K. Burr, S. Chandran, J. Newcombe, T. Lashley, I. Hubbard, Demetra Catalano, Duyang Kim, Nadia A. Propp, S. Fennessey, D. Fagegaltier, H. Phatnani, M. Secrier, E. Fisher, B. Oskarsson, M. van Blitterswijk, R. Rademakers, N. Graff-Radford, B. Boeve, D. Knopman, R. Petersen, K. Josephs, E. Thompson, T. Raj, Michael E. Ward, Dennis W. Dickson, Tania F. Gendron, P. Fratta, L. Petrucelli   +51 more
semanticscholar   +1 more source

Plasma glial fibrillary acidic protein is raised in progranulin-associated frontotemporal dementia

Journal of Neurology Neurosurgery & Psychiatry, 2020
Background There are few validated fluid biomarkers in frontotemporal dementia (FTD). Glial fibrillary acidic protein (GFAP) is a measure of astrogliosis, a known pathological process of FTD, but has yet to be explored as potential biomarker.
Carolin Heller, M. Foiani, K. Moore, R. Convery, M. Bocchetta, Mollie Neason, D. Cash, D. Thomas, C. Greaves, I. Woollacott, R. Shafei, J. V. van Swieten, F. Moreno, Raquel Sánchez-Valle, B. Borroni, R. Laforce Jr., M. Masellis, M. Tartaglia, C. Graff, D. Galimberti, J. Rowe, E. Finger, M. Synofzik, R. Vandenberghe, A. de Mendonça, F. Tagliavini, I. Santana, S. Ducharme, C. Butler, A. Gerhard, J. Levin, A. Danek, G. Frisoni, S. Sorbi, M. Otto, A. Heslegrave, H. Zetterberg, J. Rohrer   +37 more
semanticscholar   +1 more source

Fluid biomarkers in frontotemporal dementia: past, present and future

Journal of Neurology Neurosurgery & Psychiatry, 2020
The frontotemporal dementia (FTD) spectrum of neurodegenerative disorders includes a heterogeneous group of conditions. However, following on from a series of important molecular studies in the early 2000s, major advances have now been made in the ...
Imogen J. Swift, Aitana Sogorb-Esteve, Carolin Heller, M. Synofzik, M. Otto, C. Graff, D. Galimberti, E. Todd, A. Heslegrave, E. L. van der Ende, J. V. van Swieten, H. Zetterberg, J. Rohrer   +12 more
semanticscholar   +1 more source

Looking beneath the surface: the importance of subcortical structures in frontotemporal dementia

Brain Communications, 2021
Whilst initial anatomical studies of frontotemporal dementia focussed on cortical involvement, the relevance of subcortical structures to the pathophysiology of frontotemporal dementia has been increasingly recognized over recent years.
M. Bocchetta, M. Malpetti, E. Todd, J. Rowe, J. Rohrer   +4 more
semanticscholar   +1 more source

Interpersonal prosodic correlation in frontotemporal dementia. [PDF]

, 2019
Communication accommodation describes how individuals adjust their communicative style to that of their conversational partner. We predicted that interpersonal prosodic correlation related to pitch and timing would be decreased in behavioral variant ...
Chen, Kuan-Hua, Cohen, Kevin B, Gorno-Tempini, Maria Luisa, Hunter, Lawrence E, Levenson, Robert W, Miller, Bruce L, Pressman, Peter S, Ross, Elliott D   +7 more
core   +1 more source

The role of hnRNPs in frontotemporal dementia and amyotrophic lateral sclerosis

Acta Neuropathologica, 2020
Dysregulated RNA metabolism is emerging as a crucially important mechanism underpinning the pathogenesis of frontotemporal dementia (FTD) and the clinically, genetically and pathologically overlapping disorder of amyotrophic lateral sclerosis (ALS ...
A. Bampton, Lauren M. Gittings, P. Fratta, T. Lashley, A. Gatt   +4 more
semanticscholar   +1 more source

Frontotemporal dementia: the impact of patient behavioral symptoms on the physical and mental health of family caregivers. [PDF]

, 2012
BackgroundProviding informal support to someone with frontotemporal dementia (FTD) could be very stressful. Clarifying the relationship between patient behavioral problems and caregiver health could spur future research on effective symptom management ...
Wallhagen, Margaret I, Wong, Cindy C
core   +3 more sources

MiR‐30b‐5p attenuates the inflammatory response and facilitates the functional recovery of spinal cord injury by targeting the NEFL/mTOR pathway

Brain and Behavior, Volume 12, Issue 12, December 2022., 2022
Silencing of NEFL inhibits the inflammatory response and functional recovery following spinal cord injury. Abstract Background Neurofilament light chain (NEFL) has been identified as a biomarker for spinal cord injury (SCI), but its effect and underlying mechanism in SCI remain unclear.
Hui Zhang, Duojun Wang, Jinyu Tong, Jianguo Fang, Zaijun Lin   +4 more
wiley   +1 more source

Functional connectivity in behavioral variant frontotemporal dementia

Brain and Behavior, Volume 12, Issue 12, December 2022., 2022
Decreased FC in the Salience Network (SN) is the most consistent finding in bvFTD. The brain's functional architecture is less interconnected and efficient in bvFTD. Symptom, behavior, cognition and disease severity are associated with changes in FC. Abstract Introduction Functional connectivity (FC)—which reflects relationships between neural activity
Luiz Kobuti Ferreira, Olof Lindberg, Alexander F Santillo, Lars‐Olof Wahlund   +3 more
wiley   +1 more source

Clinical outcomes and cognitive impairments between progressive supranuclear palsy and multiple system atrophy

Brain and Behavior, Volume 12, Issue 12, December 2022., 2022
Abstract Background Both progressive supranuclear palsy (PSP) and multiple system atrophy (MSA) belong to atypical parkinsonian syndromes. It is important to differentiate these diseases accurately. We compared clinical outcomes and cognitive impairments between PSP and MSA. Methods Eighty‐five MSA parkinsonism type (MSA‐P) patients and 76 PSP patients
Peifei Jia, Jinhong Zhang, Jiuyan Han, Yong Ji   +3 more
wiley   +1 more source