Results 31 to 40 of about 98,352 (316)

Early Cognitive/Social Deficits and Late Motor Phenotype in Conditional Wild-Type TDP-43 Transgenic Mice [PDF]

, 2016
Frontotemporal Dementia (FTD) and amyotrophic lateral sclerosis (ALS) are two neurodegenerative diseases associated to mislocalization and aggregation of TAR DNA-binding protein 43 (TDP-43).
Alfieri, Julio Armando, Müller Igaz, Lionel Ivan, Silva Pinto, Pablo Roberto   +2 more
core   +2 more sources

Frontotemporal Dementia: A Clinical Review

Journal of Education, Health and Sport
Frontotemporal dementia is a disease in which atrophic changes occur in the frontal lobes and frontal temporal lobes of the brain. Frontotemporal dementias are a clinically, neuroanatomically and pathologically diverse group of diseases that ...
Michał Dacka, Mikołaj Porzak, Karol Bochyński, Konrad Białogłowski, Paulina Dąbrowska, Michał Żuber, Katarzyna Ciuba, Katarzyna Molenda, Filip Borodziuk, Barbara Borodziuk   +9 more
doaj   +1 more source

Mutant Tau knock-in mice display frontotemporal dementia relevant behaviour and histopathology [PDF]

, 2016
Peer ...
Drever, Benjamin D., Koss, David J., Platt, Bettina, Plucinska, Kaja, Riedel, Gernot, Robinson, Lianne, Stoppelkamp, Sandra, Veselcic, Peter   +7 more
core   +3 more sources

Pharmacological treatment of frontotemporal lobar degeneration: systematic review Tratamento farmacológico da degeneração lobar frontotemporal: revisão sistemática

Brazilian Journal of Psychiatry, 2011
OBJECTIVE: To identify the therapeutic options available for treatment of cognitive and behavioral symptoms in frontotemporal lobar degeneration. METHOD: Systematic review using the descriptors "frontotemporal lobar degeneration" OR "frontotemporal ...
Maria da Glória Portugal, Valeska Marinho, Jerson Laks   +2 more
doaj   +1 more source

Habitual glucosamine use, APOE genotypes, and risk of incident cause-specific dementia in the older population

Alzheimer’s Research & Therapy, 2023
Background The relationship of glucosamine use with incident dementia in the older population remains uncertain. We aimed to evaluate the longitudinal association between habitual glucosamine supplement and the risk of cause-specific dementia and examine
Chun Zhou, Yanjun Zhang, Sisi Yang, Ziliang Ye, Qimeng Wu, Mengyi Liu, Panpan He, Yuanyuan Zhang, Xianhui Qin   +8 more
doaj   +1 more source

Pathogenic determinants and mechanisms of ALS/FTD linked to hexanucleotide repeat expansions in the C9orf72 gene. [PDF]

, 2017
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two apparently distinct neurodegenerative diseases, the former characterized by selective loss of motor neurons in the brain and spinal cord and the latter characterized by ...
Pasinelli, Piera, Trotti, Davide, Wen, Xinmei, Westergard, Thomas   +3 more
core   +2 more sources

The Ku80-p53-SIRT1 axis in DNA damage response contributes to sporadic and familial ALS and FTD

Nature Communications
Although TDP-43 pathology is found in most sporadic and familial ALS and FTD cases, other shared pathogenic mechanisms remain largely unknown. Here we show that SIRT1 levels are decreased and acetylated p53 levels are increased in iPSC-derived neurons ...
Yong-Woo Jun, Soojin Lee, Sandra Almeida, Kristine K. Freude, Justin K. Ichida, Fen-Biao Gao   +5 more
doaj   +1 more source

C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins [PDF]

, 2014
An expanded GGGGCC repeat in C9orf72 is the most common genetic cause of frontotemporal dementia and amyotrophic lateral sclerosis. A fundamental question is whether toxicity is driven by the repeat RNA itself and/or by dipeptide repeat proteins ...
Cabecinha, M, Clayton, EL, Cleverley, K, Devoy, A, Dols, J, Fisher, EMC, Fratta, P, Grönke, S, Hendrich, O, Isaacs, AM, Mizielinska, S, Moens, T, Niccoli, T, Nicoll, AJ, Norona, FE, Partridge, L, Pickering-Brown, S, Pietrzyk, J, Ridler, CE, Woollacott, IOC   +19 more
core   +1 more source

Amyotrophic Lateral Sclerosis Prevalence Projection in 2040: A Less Rare Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To project ALS prevalence across multiple countries through 2040, accounting for both population aging and increased survival. Methods Data from the Piemonte and Valle d'Aosta ALS register (PARALS) was used to estimate the trends in incidence and prevalence from 2005 to 2019. Survival trends over this period were also assessed.
Rosario Vasta, Stefano Callegaro, Antonio Canosa, Umberto Manera, Maurizio Grassano, Francesca Palumbo, Sara Cabras, Enrico Matteoni, Francesca Di Pede, Filippo De Mattei, Salvatore Tafaro, Neil M. Thakur, Ryan Grosenick, Fabiola De Marchi, Letizia Mazzini, Cristina Moglia, Andrea Calvo, Kuldip D. Dave, Adriano Chiò   +18 more
wiley   +1 more source

Systemic Sarcoidosis Mimicking a Behavioural Variant of Frontotemporal Dementia

Case Reports in Neurological Medicine, 2015
Among rare neurological manifestations, a progressive dementia may exceptionally be the revealing clinical feature of a sarcoidosis. Diagnosis may then be difficult, especially when systemic signs are missing or latent, with a risk of therapeutic delay ...
Anne De Maindreville, Line Bedos, Serge Bakchine   +2 more
doaj   +1 more source