Results 51 to 60 of about 53,213 (267)

Skeletal Muscle Biomarkers of Amyotrophic Lateral Sclerosis: A Large‐Scale, Multi‐Cohort Proteomic Study

Annals of Neurology, EarlyView.
Objective Biomarkers with clear contexts of use are important tools for amyotrophic lateral sclerosis (ALS) therapy development. Understanding their longitudinal trajectory in the untreated state is key to their use as potential markers of pharmacodynamic response.
Oleksandr Dergai, Joanne Wuu, Magdalena Koziczak‐Holbro, Andrea Malaspina, Volkan Granit, Jessica P. Hernandez, Anne Cooley, Ruchika Sachdev, Lili Yu, Michael Bidinosti, Ludivine Flotte, Mark Nash, Lori L. Jennings, James D. Berry, Lucie I. Bruijn, Sophie Brachat, Michael Benatar   +16 more
wiley   +1 more source

Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Have Distinct Prediagnostic Blood Biochemical Profiles

Annals of Neurology, EarlyView.
Objective Identifying modifiable factors influencing amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) risk is important for prevention. Blood biomarkers, particularly cholesterol, have been associated with neurodegenerative risk, but findings in ALS are inconsistent, and data on FTD are limited.
Christos V. Chalitsios, Jiali Gao, Carol A.C. Coupland, Julia Hippisley Cox, Martin R. Turner, Alexander G. Thompson   +5 more
wiley   +1 more source

Basal parasympathetic deficits in C9orf72 hexanucleotide repeat expansion carriers relate to smaller frontoinsula and thalamus volume and lower empathy

NeuroImage: Clinical
Diminished basal parasympathetic nervous system activity is a feature of frontotemporal dementia that relates to left frontoinsula dysfunction and empathy impairment.
Ashlin R. K. Roy, Fate Noohi, Nathaniel A. Morris, Peter Ljubenkov, Hilary Heuer, Jamie Fong, Matthew Hall, Argentina Lario Lago, Katherine P. Rankin, Bruce L. Miller, Adam L. Boxer, Howard J. Rosen, William W. Seeley, David C. Perry, Jennifer S. Yokoyama, Suzee E. Lee, Virginia E. Sturm   +16 more
doaj   +1 more source

Evaluating combinations of diagnostic tests to discriminate different dementia types

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2018
Introduction We studied, using a data‐driven approach, how different combinations of diagnostic tests contribute to the differential diagnosis of dementia.
Marie Bruun, Hanneke F.M. Rhodius‐Meester, Juha Koikkalainen, Marta Baroni, Le Gjerum, Afina W. Lemstra, Frederik Barkhof, Anne M. Remes, Timo Urhemaa, Antti Tolonen, Daniel Rueckert, Mark vanGils, Kristian S. Frederiksen, Gunhild Waldemar, Philip Scheltens, Patrizia Mecocci, Hilkka Soininen, Jyrki Lötjönen, Steen G. Hasselbalch, Wiesje M. van derFlier   +19 more
doaj   +1 more source

Anatomical Associations Between Focal Mitochondrial Metabolism and Patterns of Neurodegeneration in Amyotrophic Lateral Sclerosis

Annals of Neurology, EarlyView.
Objective Amyotrophic lateral sclerosis (ALS) has a very specific neuroimaging signature, but the molecular underpinnings of the strikingly selective anatomic involvement have not elucidated to date. Accordingly, a large neuroimaging study was conducted with 258 participants to evaluate associations between patterns of neurodegeneration and focal ...
Marlene Tahedl, We Fong Siah, Efstratios Karavasilis, Jennifer C. Hengeveld, Mark A. Doherty, Russell L. McLaughlin, Orla Hardiman, Ee Ling Tan, Foteini Christidi, Jana Kleinerova, Peter Bede   +10 more
wiley   +1 more source

Examining the propensity and nature of criminal risk behaviours in frontotemporal dementia syndromes and Alzheimer's disease

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
INTRODUCTION Some people with dementia develop changes in behaviour and cognition that may lead to interactions with police or the legal system. However, large, prospective case–control studies examining these behaviours are lacking.
Fiona Kumfor, Grace Wei, Nola Ries, Hayley Bennett, Mirelle D'Mello, Cassandra Kaizik, Olivier Piguet, John R. Hodges   +7 more
doaj   +1 more source

TDP‐43 Phosphorylation: Pathological Modification or Protective Factor Antagonizing TDP‐43 Aggregation in Neurodegenerative Diseases?

BioEssays, EarlyView.
TDP‐43 hyperphosphorylation occurs in neurodegenerative diseases, however, it is not a driver of TDP‐43 aggregation, but enhances TDP‐43 solubility, suggesting that TDP‐43 hyperphosphorylation is protective. Toxicity may arise from a broader phosphorylation‐driven cellular pathway disruption.
Simone Mosna, Dorothee Dormann
wiley   +1 more source

An Investigation of Hyperostosis Frontalis Interna in a Modern Anatomical Body Donor Population

Clinical Anatomy, EarlyView.
ABSTRACT This research sought to examine the prevalence and severity of hyperostosis frontalis interna (HFI) in the Chicagoland anatomical body donor population. The study further aimed to elucidate potential demographic risk factors for HFI, including sex, age at death, and structural vulnerability index (SVI), as well as any common comorbidities, as ...
Amy C. Beresheim, Amanda Hall
wiley   +1 more source

Relationship Between Ginger Consumption and Dementia/Mild Cognitive Impairment: A Cross‐Sectional Study in Shanghai

Food Frontiers, EarlyView.
The possible mechanisms by which ginger consumption affects cognitive function. ABSTRACT Previous studies have found some cognitive benefits from ginger consumption, but there are little data on this among older Chinese. To explore the relationship between ginger consumption and dementia and explore the possible mechanism of ginger consumption on ...
Wei Li, Lin Sun, Xia Li, Ling Yue, Shifu Xiao   +4 more
wiley   +1 more source

Examining the relation between bilingualism and age of symptom onset in frontotemporal dementia [PDF]

, 2023
Jessica de Leon, Stephanie M. Grasso, Isabel Elaine Allen, Danielle P. Escueta, Yvette Vega, Malihe Eshghavi, Christa Watson, Nina F. Dronkers, Maria Luisa Gorno‐Tempini, Maya L. Henry   +9 more
openalex   +1 more source