Results 71 to 80 of about 47,802 (187)

Reduced SH3RF3 May Protect Against Alzheimer's Disease by Lowering Microglial Pro‐Inflammatory Responses via Modulation of JNK and NFkB Signaling

Glia, Volume 74, Issue 7, July 2026.
SNPs in SH3RF3 decrease the age of onset of Alzheimer's disease (AD). Reduced SH3RF3 blunts human microglial JNK and NFkB signaling and downstream inflammatory cytokine production, which may partially explain how SH3RF3 SNPs protect against AD. ABSTRACT Understanding how high‐risk individuals are protected from Alzheimer's disease (AD) may illuminate ...
Ronak Patel, Rong Cheng, Christopher L. Cardona, Ellen Angeles, Gunjandeep Singh, Sabrina Miller, Archana Ashok, Andrew F. Teich, Angel Piriz, Aleyda Maldonado, Ivonne Z. Jiménez‐Velázquez, Richard Mayeux, Joseph H. Lee, Andrew A. Sproul   +13 more
wiley   +1 more source

Heterozygous OGDH Variants Are Involved in Peripheral Neuropathy With Ataxia and Optical Atrophy

JIMD Reports, Volume 67, Issue 4, July 2026.
ABSTRACT 2‐oxyglutarate dehydrogenase (OGDH) encodes an E1 component of α‐ketoglutarate dehydrogenase complex that plays a pivotal role in the Krebs cycle. Biallelic variants in OGDH have been reported to cause an early‐onset neurodevelopmental and mitochondrial disorder.
Liedewei Van de Vondel, Gyu S. Lee, Jonathan De Winter, Satoshi Matsuzaki, Abigail Sandoval, Juan Felipe Ramirez, Alice Monticelli, Sukyeong Lee, Rita Horvath, Jan de Bleecker, Stephan Züchner, Kenneth M. Humphries, Jonathan Baets, Wan Hee Yoon   +13 more
wiley   +1 more source

Perceptions of Speech‐Language Pathology Care in Amyotrophic Lateral Sclerosis: A Patient‐Centered Exploratory Study

Muscle &Nerve, Volume 74, Issue 1, Page 216-224, July 2026.
ABSTRACT Introduction/Aims Given limited research on patient perspectives of speech‐language pathology (SLP) services in ALS care, this study aimed to assess the satisfaction with, and understanding of, SLP services by people with ALS (pwALS) and to examine the alignment between services received and patient‐reported impairments.
Jennafer D. Best, Mario A. Landera, Ruixuan Ma, Bridget J. Perry   +3 more
wiley   +1 more source

Assessing the Adaptive/Maladaptive Strategies of Mastication in Older Taiwanese Individuals Using the Masticatory Adaptation Experience Questionnaire (MAEQ)

Journal of Oral Rehabilitation, Volume 53, Issue 7, Page 1306-1318, July 2026.
The study aims to establish the Masticatory Adaptation Experience Questionnaire (MAEQ) and investigate age‐related factors of masticatory adaptation. ABSTRACT Background There are various tests to assess the individual performance of mastication. However, it has remained unknown how individuals used adaptive (e.g., ‘increasing time to chew’) and ...
Chia‐Shu Lin, Ta‐Chung Chen, Yi‐Chen Chen, Li‐Jung Chao, Wei‐Chieh Kao, Jong‐Ling Fuh   +5 more
wiley   +1 more source

Fluid and Neuroimaging Biomarkers in Microgliopathy Colony‐Stimulating Factor‐1 Receptor‐Related Disorders

Annals of Clinical and Translational Neurology, Volume 13, Issue 6, Page 1236-1248, June 2026.
ABSTRACT Objective This study aims to identify both fluid and neuroimaging biomarkers for CSF1R‐RD that can inform the optimal timing of treatment administration to maximize therapeutic benefit, while also providing sensitive quantitative measurements to monitor disease progression.
Tomasz Chmiela, Madison Reeves, Karen Jansen‐West, Judith Dunmore, Yuping Song, Audrey Strongosky, Sunil Gandhi, Gilana Pikover, Matt Blurton‐Jones, Robert C. Spitale, Erik H. Middlebrooks, Leonard Petrucelli, Mercedes Prudencio, Zbigniew K. Wszolek   +13 more
wiley   +1 more source

WWOX Mutation as a Rare Cause of Neonatal‐Infantile Parkinsonism Mimicking a Neurotransmitter Disorder: A Case Report

Journal of Paediatrics and Child Health, EarlyView.
Ozge Serce Pehlevan, Gizem Gider Yaman, Anıl Gok, Leman Tekin Orgun   +3 more
wiley   +1 more source

A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility

Annals of Clinical and Translational Neurology, Volume 13, Issue 6, Page 1088-1105, June 2026.
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento, Daniela F. Santos, Tuane C. R. G. Vieira, Tiago F. Outeiro   +3 more
wiley   +1 more source

Factors linked to informal caregiver burden in dementia across Latin America and the Caribbean: A systematic review and meta‐analysis

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract Informal caregivers are central to dementia care in Latin America and the Caribbean (LAC), yet determinants of caregiver burden remain insufficiently characterized. We conducted a systematic review and meta‐analysis of studies examining patient‐ and caregiver‐related correlates of burden in LAC.
Paula Quintero‐Cardona, María Alejandra Tangarife, John Blandon, Juan Carlos Arango‐Lasprilla, Agustin Ibanez, Sandra Baez   +5 more
wiley   +1 more source

Social vulnerability shapes deep clinical phenotypes and brain health in aging and dementia across Latin America

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION Adverse social conditions across the life course influence brain aging and dementia, yet their compounded impact on clinical phenotypes remains underexplored, particularly in Latin America, where social inequality and dementia burden are high.
Temitope Farombi, Tiago Azzi, Agustina Legaz, David Aguillón, José Alberto Avila‐Funes, Maria Isabel Behrens, Martín Bruno, Juan Felipe Cardona, Nilton Custodio, Carolina Delgado, Stefanie Pina‐Escudero, Maria del Pilar Garavito Galofre, Marcelo Maito, Nahuel Magrath‐Guimet, Justin B. Miller, Diana Matallana, Maira Okada de Oliveira, Guido Rocatti, Elisa de Paula França Resende, Andrea Slachevsky, Leonel Takada, Olivia Wen, Lina M. Zapata‐Restrepo, Brian Lawlor, Kristine Yaffe, Kun Hu, Bruce Miller, Katherine Possin, Jennifer S. Yokoyama, Sol Fittipaldi, Adolfo M. García, Hernan Hernandez Larzabal, Hernando Santamaria‐Garcia, Enzo Tagliazzuchi, Claudia Duran‐Aniotz, Agustin Ibanez, Joaquin Migeot   +36 more
wiley   +1 more source

Functional neuroanatomy of musical object processing in Alzheimer's disease and frontotemporal dementia. [PDF]

Brain Commun
Core LB, Froud SA, Wastling S, Jiang J, Levett BA, Mancini L, Dymerska B, Hardy CJD, Zeidman P, Warren JD.   +9 more
europepmc   +1 more source