Results 81 to 90 of about 50,646 (233)

Research progress of behavioral variant frontotemporal dementia

Chinese Journal of Contemporary Neurology and Neurosurgery, 2015
There is no epidemiological data of frontotemporal dementia (FTD) in China. The application of updated diagnostic criteria, publishing of frontotemporal lobar degeneration (FTLD) consensus in China, development of multimodal imaging and biomarkers ...
Xiao-hua GU, Jun XU
doaj  

Frontotemporal Dementia—A Chameleon?

The Primary Care Companion For CNS Disorders, 2011
To the Editor: Frontotemporal dementia (FTD) is a pathologically heterogeneous illness characterized by progressive atrophy of the frontal and anterior temporal cortex. Some cases are familial, but the etiology is more often idiopathic.1 There is no known treatment, and the illness progresses inexorably to death, with a mean survival of about 8 years.1
Inyene E, Umoren, Jean M, Fils, Jonathan T, Stewart   +2 more
openaire   +3 more sources

Co‐ and Multi‐Pathologies in Parkinson's Disease: An International Parkinson and Movement Disorder Society Scientific Issues Committee Review

Movement Disorders, EarlyView.
Abstract Parkinson's disease (PD) has been historically defined as a disease of striatal dopamine deficiency secondary to degeneration of dopaminergic neurons in the substantia nigra pars compacta, related to the presence of Lewy bodies and Lewy neurites.
Michele Matarazzo, Per Borghammer, Inas Elsayed, Jennifer G. Goldman, Yue Huang, Katja Lohmann, Per Svenningsson, Lorraine V. Kalia, Daniela Berg, Jeffrey H. Kordower, the MDS Scientific Issues Committee   +10 more
wiley   +1 more source

From Uncertainty to Pathogenicity: Resolving a CSF1R Variant of Uncertain Significance Using Long‐Read Transcriptomics

Movement Disorders, EarlyView.
Abstract Background CSF1R‐related disorder (CSF1R‐RD) is a severe autosomal dominant leukoencephalopathy characterized by progressive cognitive, neuropsychiatric, and motor decline. Although genetic testing is widely available, numerous likely pathogenic variants in CSF1R frequently remain classified as variants of uncertain significance (VUS ...
Charles Wade, Kylie Montgomery, Gabriela E. Jones, Peter Sellars, Akram A. Hosseini, Simon Paine, Henry Houlden, Mina Ryten, David S. Lynch   +8 more
wiley   +1 more source

Generation and characterization of two induced pluripotent stem cell lines (ICGi052-A and ICGi052-B) from a patient with frontotemporal dementia with parkinsonism-17 associated with the pathological variant c.2013T>G in the MAPT gene

Вавиловский журнал генетики и селекции
Frontotemporal dementia with parkinsonism-17 is a neurodegenerative disease characterised by pathological aggregation of the tau protein with the formation of neurofibrillary tangles and subsequent neuronal death.
E. V. Grigor’eva, A. A. Malakhova, E. S. Yarkova, J. M. Minina, Y. V. Vyatkin, J. A. Nadtochy, E. A. Khabarova, J. A. Rzaev, S. P. Medvedev, S. M. Zakian   +9 more
doaj   +1 more source

Frontotemporal dementia [PDF]

Continuum, 2007
Indre Viskontas, Bruce Miller
openaire   +1 more source

Post‐Omicron cognitive decline is largely reversible: Two‐year multicenter cohort study of domain‐specific outcomes in hospitalized patients

Neuroprotection, EarlyView.
Earlier variants of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2), including the original strain, Alpha and Delta, were linked to significant and persistent cognitive impairment. The long‐term cognitive impact of Omicron infection, however, has remained uncertain. This study shows that post‐Omicron cognitive decline is largely reversible,
Min Qiu, Mengwen Wang, Shengcai Chen, Wenbo Zuo, Jiashuo Lin, Luojinyun Wang, Senwei Tan, Quanwei He, Yanan Li, Huijuan Jin, Xuan Niu, Wanli Li, Fengguang Li, Ming Huang, Yan Wan, Bo Hu   +15 more
wiley   +1 more source

Data‐driven thresholds for standardized classification of severe Alzheimer's disease neuropathology using digital neuropathology

Brain Pathology, EarlyView.
We generated digital pathologic algorithms (AI‐based modules that can be freely shared) to: optimize the sampling (ROI) for diagnosis of ADNC‐related tau pathology; compare/transition between Aperio and HALO platforms; and rationalize severe Braak NFT staging, so that all Braak‐VI cases had dementia, and all Braak‐V cases had MCI or dementia.
Ryan K. Shahidehpour, Allison M. Neltner, Mitchell A. Klusty, Cole Corbett, Angelique D. Gonzalez, David A. Gutman, David W. Fardo, Adam D. Bachstetter, Cody Bumgardner, Margaret E. Flanagan, Peter T. Nelson   +10 more
wiley   +1 more source

Amyotrophic lateral sclerosis in a combination with frontotemporal dementia: A clinical case study

Heart Vessels and Transplantation
Objective: Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease affecting both central and peripheral motor neurons, presenting a significant challenge in modern neurology. This article discusses the multifactorial nature of ALS,
Nurzhan T. Dzhaparalieva, Eldana .B.Bolotbekova, Begimai B. Kadyrova, Irina A. Sverdlova, Asel T. Jusupova   +4 more
doaj   +1 more source

Wasteosomes accumulate in periventricular white matter hyperintensities and exhibit complex relationships with mixed pathology, sclerotic index, and perivascular space

Brain Pathology, EarlyView.
In a mixed diagnostic cohort of pathologically diagnosed Alzheimer's disease, cerebrovascular disease, mixed pathology, and control tissue, we connected the histopathological wasteosome profile in periventricular (PV) brain sections to 7T FLAIR‐MRI confirmed PV white matter hyperintensities (WMHs), vascular stenosis and perivascular space size ...
Nikita Ollen‐Bittle, Isabella Boesgaard, Austyn Roseborough, Meaghan Frank, Qi Zhang, Stephen H. Pasternak, Robert Hammond, Shawn N. Whitehead   +7 more
wiley   +1 more source