Results 81 to 90 of about 47,802 (187)

Cerebral small vessel disease and cognition in older adults across the neurodegenerative spectrum: insights from the COMPASS‐ND study

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION Imaging‐based cerebral small vessel disease (CSVD) summary scores quantify CSVD burden. This study characterized CSVD scores and assessed their cognitive associations in older adults with various neurodegenerative diseases and cognitive profiles.
Dylan X. Guan, Zahinoor Ismail, Graham A. McLeod, Shahab Marzoughi, Eric E. Smith, Aravind Ganesh   +5 more
wiley   +1 more source

Peripheral immune profiling in frontotemporal dementia. [PDF]

Brain Commun
Gamez N, Eid AM, Pascual B, Li D, Wang Y, Masdeu JC, Appel SH, Faridar A.   +7 more
europepmc   +1 more source

Validity of the two different scoring methods of the Clinical Dementia Rating scale in staging and detection of cognitive impairment in the Peruvian population

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION In Peru, the Global Deterioration Scale is the only available tool for assessing dementia severity. The Spanish translation and cultural adaptation of the Clinical Dementia Rating (CDR) is used locally but requires formal psychometric validation in the Peruvian sociocultural context.
Junior Senador, Rosa Montesinos, Belén Custodio, Jose Huilca, Katherine Agüero, Graciet Verastegui, Pamela Bartolo, Milagros Nuñez‐Huanca, María Fe Albujar Pereira, Nilton Custodio   +9 more
wiley   +1 more source

Remote, self‐administered, smartphone cognitive testing in a registry‐based cohort: Feasibility, reliability, and validity findings

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract BACKGROUND Remote, smartphone‐based cognitive testing may improve access to cognitive assessments for Alzheimer's disease and related dementias. We evaluated the feasibility, reliability, and validity of unsupervised smartphone‐based cognitive tests in a registry‐based cohort.
Sreya Dhanam, Mark Sanderson‐Cimino, Jack Carson Taylor, Emily W. Paolillo, Ray Fregly, Winnie Kwang, Paul Maruff, Amy Wise, Hilary W. Heuer, Leah K. Forsberg, Joel H. Kramer, Bradley F. Boeve, Howard J. Rosen, R. Scott Mackin, Michael W. Weiner, Rachel L. Nosheny, Adam L. Boxer, Adam M. Staffaroni, and the Brain Health Registry   +18 more
wiley   +1 more source

Sex‐Specific Genetic Architecture of ALS: Evidence of a Female Protective Effect?

Annals of Neurology, Volume 99, Issue 6, Page 1536-1544, June 2026.
Background Amyotrophic lateral sclerosis (ALS) shows sex differences in incidence and age of onset, yet the underlying biological mechanisms remain poorly understood. Methods We investigated sex‐specific genetic architecture in an Italian ALS cohort with whole‐genome sequencing (1,333 ALS cases, 755 controls).
Maurizio Grassano, Francesca Palumbo, Gabriele Mora, Salvatore Gallone, Giovanni De Marco, Ilaria Merulla, Claudia Paolantonio, Alessandra Maccabeo, Antonio Canosa, Umberto Manera, Rosario Vasta, Barbara Iazzolino, Marcella Testa, Giuseppe Fuda, Paolina Salamone, Giulia Marchese, Federico Casale, Cristina Moglia, Andrea Calvo, Giuseppe Borghero, Adriano Chiò   +20 more
wiley   +1 more source

Distinct Prescription Patterns Emerge Years Before ALS Diagnosis: A Nationwide Registry‐Based Study

Annals of Neurology, Volume 99, Issue 6, Page 1516-1525, June 2026.
Objective The prodromal phase of amyotrophic lateral sclerosis (ALS) is poorly defined. We aimed to characterize prescription drug use patterns in the pre‐diagnostic period by analyzing nationwide prescription data to identify the earliest divergence between individuals who developed ALS and matched healthy controls.
Magne Haugland Solheim, Trond Riise, Marianna Cortese, Ola Nakken, Ole‐Bjørn Tysnes, Jannicke Igland, Kjetil Bjornevik   +6 more
wiley   +1 more source

Chronological Diagnostic Algorithm Predicting Neuropathology in Parkinsonism

Annals of Neurology, Volume 99, Issue 6, Page 1405-1414, June 2026.
Objective Pre‐mortem diagnosis of parkinsonism is often challenging due to atypical presentations, overlapping syndromes, and co‐pathologies. This study aimed to develop a machine learning‐based algorithm predicting neuropathology in parkinsonism using chronological clinical presentations, which has previously been underexplored.
Daisuke Ono, Hiroaki Sekiya, Alexia R. Maier, Neill R. Graff‐Radford, Zbigniew K. Wszolek, Dennis W. Dickson   +5 more
wiley   +1 more source

Frontotemporal dementia and psychiatry [PDF]

International Review of Psychiatry, 2013
Chiadi U, Onyike, Edward D, Huey
openaire   +2 more sources

Diagnosis of Frontotemporal Dementia in Individuals With Late-Onset Behavioral Changes: Importance of Genetic Counseling. [PDF]

Neurol Genet
Irwin DJ.
europepmc   +1 more source

Temporal Modeling of Amyloid and Tau Trajectories in Alzheimer's Disease Using PET and Plasma Biomarkers

Annals of Neurology, Volume 99, Issue 6, Page 1438-1451, June 2026.
Objective This study aimed to compare positron emission tomography (PET) and plasma‐based temporal modeling of amyloid and tau biomarkers in Alzheimer's disease. Methods Longitudinal amyloid PET (n = 1,097, mean age ± SD = 72.5 ± 7.38 year, 51.4% male), 18F‐flortaucipir tau‐PET (n = 230, 74.3 ± 7.18 year, 52.2% female), and Fujirebio Lumipulse plasma p‐
Christopher A. Brown, Katheryn A.Q. Cousins, Magdalena Korecka, Emily McGrew, Alice Chen‐Plotkin, John A. Detre, Corey T. McMillan, Edward B. Lee, Sandhitsu R. Das, Dawn Mechanic‐Hamilton, Paul A. Yushkevich, Ilya M. Nasrallah, Leslie M. Shaw, for the Alzheimer's Disease Neuroimaging Initiative, David A. Wolk   +14 more
wiley   +1 more source