Results 101 to 110 of about 47,802 (187)

Exploring and Targeting the Connection of Iron and Copper Homeostasis to Neurodegenerative Diseases

MedComm, Volume 7, Issue 6, June 2026.
Iron and copper dyshomeostasis, along with their interactions with key intrinsically disordered proteins (e.g., Aβ, tau, α‐synuclein) have a strong implication in the onset and progression of neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), Prion diseases (PrDs), Huntington's disease (HD), Wilson's disease (WD),
Xin Liu, Lin Jia, Kerong Wu, Mo Chen, Jichao Sun, Chuanbin Yang, Chengchao Xu, Jie Sun, Jigang Wang, Lingyun Dai   +9 more
wiley   +1 more source

Altered amygdala structural connectivity and relations to social cognition in frontotemporal dementia. [PDF]

Alzheimers Dement
Huang M, Dalton MA, Matis S, Teng HAC, Cheung SC, Hwang YT, Ahmed RM, Landin-Romero R, Piguet O.   +8 more
europepmc   +1 more source

Loss of SMARCAD1 Mitigates Tauopathy

Aging Cell, Volume 25, Issue 6, June 2026.
Using genetics approaches in a C. elegans transgenic model of tauopathy, we uncover a role for the homolog of human SMARCAD1, a regulator of chromatin dynamics. ABSTRACT Tauopathies are neurodegenerative diseases characterized by the accumulation of misfolded tau protein and include Alzheimer's disease (AD) and related dementia disorders.
Vaishnavi S. Jadhav, Rebecca L. Kow, Asia D. Beale, Misa Baum, Pamela J. McMillan, Caitlin S. Latimer, Nicole F. Liachko, Brian C. Kraemer   +7 more
wiley   +1 more source

Lower Risk of Cardiovascular Events in Patients With Clinical Atherosclerotic Cardiovascular Disease Who Initiated Semaglutide 2.4 mg in the Real‐World: Results From the SCORE—Clinical ASCVD Study

Diabetes, Obesity and Metabolism, Volume 28, Issue 6, Page 4975-4990, June 2026.
ABSTRACT Aims To evaluate the association between semaglutide 2.4 mg and major adverse cardiovascular events (MACE) among adults with clinical atherosclerotic cardiovascular disease (ASCVD) and overweight/obesity without diabetes in real‐world clinical practice.
Michael G. Nanna, Carlos Mena‐Hurtado, Victoria Divino, Zhenxiang Zhao, Yan Chen, Joanna Boland, Jinlin Song, Andrea Traina, Kerem Ozer, Filip K. Knop, Kim G. Smolderen   +10 more
wiley   +1 more source

Cumulative Incidence in Monogenic Alzheimer's Disease and Frontotemporal Dementia: Gene-Gene Interaction Effect. [PDF]

Int J Mol Sci
Geviti A, Pagano L, Grassi M, Saraceno C, Facconi A, Fostinelli S, Laganà V, Giacomucci G, Cotelli MS, Cantoni V, Ingannato A, Bagnoli S, Bessi V, Longobardi A, Russotto A, Bellini S, Lagrotteria D, Paparazzo E, Binetti G, Montesanto A, Nacmias B, Maletta R, Borroni B, Ghidoni R.   +23 more
europepmc   +1 more source

Investigating Disordered Eating Behaviours Among Individuals Living With Neurodegenerative Disease: A Scoping Review

Journal of Human Nutrition and Dietetics, Volume 39, Issue 3, June 2026.
ABSTRACT Aim Neurodegenerative diseases and disordered eating have become rapidly expanding areas of research. However, research addressing the relationship between the two is lacking. Methods A scoping review guided by the Joanna Briggs Institute methodological framework was completed to synthesise the evidence related to disordered eating behaviours ...
Emily Buttifant, Shoroog Allogmanny, Yasmine Probst   +2 more
wiley   +1 more source

Effects of Lysine Deacetylation Inhibition Alone or in Combination With Arimoclomol on TDP‐43 Proteinopathy

Journal of Neurochemistry, Volume 170, Issue 6, June 2026.
TDP‐43 pathology is a hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. Peptidyl‐prolyl cis–trans isomerase A (PPIA), a foldase and chaperone protein, modulates TDP‐43 function in an acetylation‐dependent manner. Here, we show that inhibition of lysine deacetylation with vorinostat (SAHA) increases PPIA acetylation and ...
Serena Scozzari, Stefano Fabrizio Columbro, Monica Favagrossa, Massimo Tortarolo, Alfredo Cagnotto, Mario Salmona, Giovanni De Marco, Caterina Bendotti, Andrea Calvo, Laura Pasetto, Valentina Bonetto   +10 more
wiley   +1 more source

The Long Haul: Microtubule Motors as the Essential Supply Line for Neuronal Longevity

Journal of Neurochemistry, Volume 170, Issue 6, June 2026.
To survive a lifetime, neurons depend on a high‐fidelity logistics network powered by microtubule motors. We explore how a broad spectrum of genetic defects in this machinery drive a devastating spectrum of neurodevelopmental and neurodegenerative diseases, including Hereditary Spastic Paraplegia (HSP), Charcot–Marie‐Tooth Type 2 (CMT2), and ...
Emma D. Turner, Alison E. Twelvetrees
wiley   +1 more source

A next-generation HDAC6 inhibitor for amyotrophic lateral sclerosis and frontotemporal dementia. [PDF]

Brain
James RE, Bekier M, Lee PJ, Schroeder FA, Evans LT, Wagner FF, Hickman D, Richardson T, Hatzipetros T, Vieira F, Callizot N, Modi S, Hooker JM, Kranz JE, Brown RH, Barmada SJ, Gilbert TM.   +16 more
europepmc   +1 more source

Co‐pathologies and biological processes beyond amyloid‐beta and tau in people with Alzheimer's disease: Evidence from clinical cohort studies

Journal of Internal Medicine, Volume 299, Issue 6, Page 694-710, June 2026.
Abstract Alzheimer's disease (AD) is neuropathologically defined by amyloid‐beta (Aβ) plaques and tau neurofibrillary tangles. However, co‐pathologies and other pathobiological processes are involved in the pathogenesis of AD, contributing to neurodegeneration and clinical symptoms.
Daniel Ferreira, Tomasz Chmiela, Maria Eriksdotter, Clifford R. Jack Jr., Grégoria Kalpouzos, Anna Marseglia, Patrizia Mecocci, Agneta Nordberg, Dorota Religa, Eric Westman   +9 more
wiley   +1 more source