Results 121 to 130 of about 329,751 (255)

The Role of Conventional MRI in the Assessment of Patients with Dementia

Minia Journal of Medical Research
Background: Dementia is a heterogeneous clinical syndrome in which neuroimaging is required to exclude potentially treatable structural abnormalities and to identify patterns that support etiological classification.
Shemaa El sharakawy, Omnia Abdelatif Ahmed, Enas Ahmed Mohamed Abdel-gawad, Tasneem Osama   +3 more
doaj   +1 more source

Lysosomal Expression Profile in Plasma Associates with Disease Severity in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Parkinson's disease (PD) is a clinically and biologically heterogeneous neurodegenerative disorder, driven by multiple mechanisms among which are lysosomal and mitochondrial dysfunction. Here, we explored blood‐based lysosomal and mitochondrial profiles in relation to PD diagnosis and severity.
Janna van Wetering, Manon M. van Ingen, Evelien Timmermans, Sjors G.J.G. in't Veld, Henk W. Berendse, Charlotte E. Teunissen, Wilma D.J. van de Berg   +6 more
wiley   +1 more source

Frontotemporal dementia linked to chromosome 3

, 2004
A large pedigree with autosomal dominant frontotemporal dementia has been identified. Positional cloning has linked the disease gene to the pericentromeric region of chromosome 3.
Gade, A, Skibinski, G, Thusgaard, T, Collinge, J, Yancopoulou, D, Sorensen, A, Johannsen, P, Spillantini, M, Brun, Arne, Chakrabarti, L, Gydesen, S, Fisher, E, Brown, J, Brun, Arne,, Lund University.   +14 more
core   +1 more source

Care home design for people with dementia: What do people with dementia and their family carers value? [PDF]

, 2011
Objectives: To report on the views of people with dementia who live in care homes and their family carers on aspects of design that are important to them, and discuss these in relation to developing physical care environments that respond to the wishes ...
Innes, Anthea, Dincarslan, Ozlem, Fiona Kelly, Ozlem Dincarslan, Kelly, Fiona, Anthea Innes, Dincarslan, O.   +6 more
core   +1 more source

Emergencies in Amyotrophic Lateral Sclerosis

Muscle &Nerve, EarlyView.
ABSTRACT Emergencies are frequent in people living with amyotrophic lateral sclerosis (pALS), especially as the disease progresses, and can necessitate urgent evaluation and intervention. Progressive weakness in ALS inevitably increases fall risk, making discussion of fall prevention strategies integral to caring for pALS.
S. Pinar Uysal, Katherine A. Dudley, Stacey Sullivan, Kate T. Brizzi, Katherine M. Burke, Sydney Hall, Kiersten Pease, Joshua N. Goldstein, James D. Berry, Doreen T. Ho   +9 more
wiley   +1 more source

Agraphia in Bulbar-Onset Amyotrophic Lateral Sclerosis: Not Merely a Consequence of Dementia or Aphasia

Behavioural Neurology, 2008
The clinical significance and characteristics of writing errors in bulbar-onset amyotrophic lateral sclerosis (ALS) are not clear. We retrospectively investigated writing samples in 19 patients with bulbar-onset ALS without preceding extra-motor symptoms.
Hiroo Ichikawa, Nobuyoshi Takahashi, Soutaro Hieda, Hideki Ohno, Mitsuru Kawamura   +4 more
doaj   +1 more source

Temporal lobe epilepsy with bilateral amygdala enlargement mimicking behavioral variant frontotemporal dementia

Epileptic Disorders, EarlyView.
Kentaro Tokumoto, Takuji Nishida, Takashi Matsudaira, Etsuko Yamazaki, Norihiko Kawaguchi, Naotaka Usui, Katsumi Imai, Yushi Inoue   +7 more
wiley   +1 more source

Artificial intelligence–based 3D segmentation of tangle‐associated TDP‐43 in neurodegeneration

Brain Pathology, EarlyView.
Multiplex immunostaining of anti‐phosphorylated TDP‐43, tau (AT8, pS396, TauC3, MN423, GT38), and Thioflavin S combined with AI‐based object recognition, reconstruction, and TAT maturation analysis pipeline in limbic regions revealed that distinct aggregation and tangle maturation patterns underscored region‐specific dynamics in the neurodegenerative ...
Gokhan Uruk, Hossam Youssef, Rodolfo G. Gatto, Nadia Hossain, Jennifer L. Whitwell, Robert R. Reichard, Keith A. Josephs   +6 more
wiley   +1 more source

Research progress of behavioral variant frontotemporal dementia

Chinese Journal of Contemporary Neurology and Neurosurgery, 2015
There is no epidemiological data of frontotemporal dementia (FTD) in China. The application of updated diagnostic criteria, publishing of frontotemporal lobar degeneration (FTLD) consensus in China, development of multimodal imaging and biomarkers ...
Xiao-hua GU, Jun XU
doaj  

α‐Synuclein strain homogeneity in multiple system atrophy subtypes

Brain Pathology, EarlyView.
Two different subtypes of multiple system atrophy are recognized: MSA‐C and MSA‐P. In this manuscript, Lau et al. investigate whether MSA‐C and MSA‐P are caused by different strains of α‐synuclein aggregates. By performing conformational fingerprinting experiments as well as in vitro and in vivo seeding assays, their findings suggest that both MSA‐C ...
Heather H. C. Lau, Nicholas R. G. Silver, Surabhi Mehra, Raphaella W. L. So, Le yao Li, Alison Mao, Erica Stuart, Cian Schmitt‐Ulms, Bradley T. Hyman, Martin Ingelsson, Joel C. Watts   +10 more
wiley   +1 more source