Results 71 to 80 of about 53,213 (267)

Frontotemporal dementia: diagnostic borders.

INFAD, 2018
Frontotemporal dementia (FTD) has a lower prevalence than Alzheimer Disease (AD), but its age of onset takes place earlier, between 50 and 60 years. For this reason, it supposes a great overload for caregivers and an increasing dependence for patients ...
Mª Cruz Pérez Lancho, Sergio García Bercianos   +1 more
doaj   +1 more source

Longitudinal Brain Atrophy Rates in Presymptomatic Carriers of Genetic Frontotemporal Dementia [PDF]

, 2022
Jackie M. Poos, Leonie D. M. Grandpierre, Emma L. van der Ende, Jessica Panman, Janne M. Papma, Harro Seelaar, Esther van den Berg, Ronald van ’t Klooster, Esther E. Bron, Rebecca M. E. Steketee, Meike W. Vernooij, Yolande A.L. Pijnenburg, Serge A.R.B. Rombouts, John C. van Swieten, Lize C. Jiskoot   +14 more
openalex   +1 more source

AZP2006 in Progressive Supranuclear Palsy: Outcomes from a Phase 2a Multicenter, Randomized Trial, and Open‐Label Extension on Safety, Biomarkers, and Disease Progression

Movement Disorders, EarlyView.
Abstract Objectives The aim was to evaluate the safety, tolerability, pharmacokinetics, and potential clinical efficacy of AZP2006, an oral pleiotropic drug modulating progranulin levels, in patients with progressive supranuclear palsy (PSP), a rare tauopathy. Methods A randomized, double‐blind, placebo‐controlled, parallel‐group trial was conducted at
Jean‐Christophe Corvol, Mickael Alexandre Obadia, Caroline Moreau, Louise‐Laure Mariani, Jean‐Philippe Brandel, David Devos, Sara Sambin, Nicolas Carrière, Günter Höglinger, Marie Lebouteux, Graziella Mangone, Noelle Callizot, Aurélien Blondel, Olivier Defert, Cecilia Estrella, Artin Karapet, Philippe Verwaerde, Luc Defebvre   +17 more
wiley   +1 more source

Research progress of behavioral variant frontotemporal dementia

Chinese Journal of Contemporary Neurology and Neurosurgery, 2015
There is no epidemiological data of frontotemporal dementia (FTD) in China. The application of updated diagnostic criteria, publishing of frontotemporal lobar degeneration (FTLD) consensus in China, development of multimodal imaging and biomarkers ...
Xiao-hua GU, Jun XU
doaj  

Epistemics and frontotemporal dementia

Ricerche di Pedagogia e Didattica, 2014
We explore how patients with the behavioural variant of frontotemporal dementia (bvFTD) display different degrees of understanding when reporting on their experience of being ill. Using the methods of conversation analysis, we examine thevideo-recordings
Peter Muntigl, Stephanie Hödl, Gerhard Ransmayr   +2 more
doaj   +1 more source

Dataset for the project "Dissecting molecular mechanisms triggered by progressive loss of progranulin and C9orf72 in frontotemporal dementia: novel therapeutic targets? (RF-2016-02361492)

, 2022
Roberta Ghidoni, Giacomina Rossi, Claudia Verderio   +2 more
openalex   +1 more source

Frontotemporal dementia presentation in patients with heterozygous p.H157Y variant of TREM2 [PDF]

, 2023
Natalia Ogonowski, Hernando Santamaría‐García, Sandra Báez, Andrea López, Andrés Laserna, Elkin Garcia‐Cifuentes, Paola Ayala‐Ramírez, Ignacio Zarante, Fernando Suárez‐Obando, Pablo Reyes, Marcelo Kauffman, Nick Cochran, M. Schulte, Daniel W. Sirkis, Salvatore Spina, Jennifer S. Yokoyama, Bruce L. Miller, Kenneth S. Kosik, Diana Matallana, Agustín Ibáñez   +19 more
openalex   +1 more source

Rare but Relevant? Assessing Variants in Dystonia‐Linked Genes in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Dystonia and Parkinson's disease (PD) exhibit clinical and genetic overlap, but the relevance of dystonia gene variants in PD remains unclear. Objective The aim was to assess the frequency of dystonia‐linked pathogenic variants in PD.
Lara M. Lange, Zih‐Hua Fang, Laurel Screven, Ai Huey Tan, Roy N. Alcalay, Rim Amouri, Roberta Bovenzi, Matilda Fenn, Joshua L.I. Frost, Joseph Jankovic, Simona Jasaityte, Zane Jaunmuktane, Beomseok Jeon, Ignacio Juan Keller Sarmiento, Rejko Krüger, Gregor Kuhlenbäumer, Chin‐Hsien Lin, Lukas Pavelka, Maria Teresa Periñan, Samia Ben Sassi, Tommaso Schirinzi, Jung Hwan Shin, Joshua M. Shulman, Yi Wen Tay, Ryan Uitti, Tom Warner, Zbigniew K. Wszolek, Lesley Wu, Ruey‐Meei Wu, Kirsten E. Zeuner, Cornelis Blauwendraat, Andrew Singleton, Niccolò E. Mencacci, Huw R. Morris, Shen‐Yang Lim, Katja Lohmann, Christine Klein, the Global Parkinson's Genetics Program (GP2)   +37 more
wiley   +1 more source

Generation and characterization of two induced pluripotent stem cell lines (ICGi052-A and ICGi052-B) from a patient with frontotemporal dementia with parkinsonism-17 associated with the pathological variant c.2013T>G in the MAPT gene

Вавиловский журнал генетики и селекции
Frontotemporal dementia with parkinsonism-17 is a neurodegenerative disease characterised by pathological aggregation of the tau protein with the formation of neurofibrillary tangles and subsequent neuronal death.
E. V. Grigor’eva, A. A. Malakhova, E. S. Yarkova, J. M. Minina, Y. V. Vyatkin, J. A. Nadtochy, E. A. Khabarova, J. A. Rzaev, S. P. Medvedev, S. M. Zakian   +9 more
doaj   +1 more source

Mining Alzheimer's Interactomes, Macromolecular Complexes and Pathways for Drug Discovery

PROTEOMICS, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative disorder that leads to dementia. Many cases are diagnosed annually and there is no currently available cure. Understanding the underlying disease biology of AD through the study of molecular networks, particularly by mapping clinical variants to tissue‐specific interactomes and ...
Kalpana Panneerselvam, Krishna Kumar Tiwari, Luana Licata, Simona Panni, Sylvie Ricard‐Blum, Sucharitha Balu, Susie Huget, Juan Jose Medina Reyes, Eliot Ragueneau, Livia Perfetto, Birgit Meldal, Sandra Orchard, Henning Hermjakob   +12 more
wiley   +1 more source