Results 31 to 40 of about 24,976 (233)

Asymmetrical Lobar Degenerations: Clinical, Neuropsychological, Scanning Data [PDF]

Türk Nöroloji Dergisi, 2006
OBJECTIVE: Asymmetric lobar degenerations are clinical syndromes which affect primarily one or more than one cerebral lobe and result progressive language and/or behaviour and/or cognitive dysfunction.
İpek Midi, Tülin Tanrıdağ, Aynur Mollahasanoğlu, Özen Çatan, Önder Us   +4 more
doaj  

Human Ubiquilin 2 and TDP-43 copathology drives neurodegeneration in transgenic Caenorhabditis elegans

G3: Genes, Genomes, Genetics, 2021
Amyotrophic lateral sclerosis (ALS) is a debilitating, fatal neurodegenerative disease that causes rapid muscle wasting. It shares a spectrum of symptoms and pathology with frontotemporal lobar degeneration (FTLD).
Aleen D Saxton, Brian C Kraemer
doaj   +1 more source

Rates of lobar atrophy in asymptomatic MAPT mutation carriers. [PDF]

, 2019
IntroductionThe aim of this study was to investigate the rates of lobar atrophy in the asymptomatic microtubule-associated protein tau (MAPT) mutation carriers.MethodsMAPT mutation carriers (n = 14; 10 asymptomatic, 4 converters from ...
Boeve, Bradley F, Boxer, Adam L, Brushaber, Danielle, Chen, Qin, Dheel, Christina, Fields, Julie, Forsberg, Leah, Gavrilova, Ralitza, Gearhart, Debra, Graff-Radford, Jonathan, Graff-Radford, Neill R, Jack, Clifford R, Jones, David T, Kantarci, Kejal, Knopman, David S, Kremers, Walter K, Lapid, Maria, LEFFTDS Consortium, Lesnick, Timothy G, Rademakers, Rosa, Rosen, Howie, Senjem, Matthew, Syrjanen, Jeremy, Tosakulwong, Nirubol, Wszolek, Zbigniew K   +24 more
core   +2 more sources

Frontotemporal lobar degeneration [PDF]

Archives of Neurology, 2005
Until recently, frontotemporal lobar degeneration (FTLD) was considered a rare neurodegenerative disorder that was difficult to diagnose. The publication of consensus criteria for FTLD, however, prompted systematic studies. The criteria categorize FTLD into 3 subgroups: frontotemporal dementia, semantic dementia, and progressive nonfluent aphasia.To ...
Adam L. Boxer, John Q. Trojanowski, Virginia M.-Y. Lee, Bruce L. Miller   +3 more
openaire   +3 more sources

Clinical and imaging correlates of hyperorality in syndromes associated with frontotemporal lobar degeneration. [PDF]

Psychiatry Clin Neurosci
Altomare D, Bracca V, Premi E, Micheli A, Cotelli MS, Gasparotti R, Alberici A, Borroni B.   +7 more
europepmc   +3 more sources

The novel MAPT mutation K298E:mechanisms of mutant tau toxicity, brain pathology and tau expression in induced fibroblast-derived neurons [PDF]

, 2013
Frontotemporal lobar degeneration (FTLD) consists of a group of neurodegenerative diseases characterized by behavioural and executive impairment, language disorders and motor dysfunction.
Calo, Laura, Goedert, Michel, Holton, Janice L., Iovino, Mariangela, Lashley, Tammaryn, Lund University., Lund University., Lund University., Muqit, Miratul M. K., Parmar, Malin,, Pfisterer, Ulrich,, Revesz, Tamas, Spillantini, Maria Grazia, Swingler, Robert J., Treacy, Rebecca   +14 more
core   +4 more sources

Clinical, Genetic and Neuropathological Features of Frontotemporal Dementia: An Update and Guide

Acta Médica Portuguesa, 2013
Introduction: Frontotemporal Lobar Degeneration encompasses a group of heterogeneous disorders with shared behavioural and cognitive symptoms, as well as gross pathological features.
Jorge Pelicano Paulos, João Massano
doaj   +1 more source

Hexanucleotide Repeat Expansion in C9ORF72 Is Not Detected in the Treatment-Resistant Schizophrenia Patients of Chinese Han. [PDF]

PLoS ONE, 2015
Hexanucleotide (GGGGCC) repeat expansion in C9ORF72 (HRE) causes frontotemporal lobar degeneration, frontotemporal dementia-amyotrophic lateral sclerosis, and amyotrophic lateral sclerosis.
Xijia Xu, Shiping Xie, Xiaomeng Shi, Jie Lv, Xiaowei Tang, Xiaolan Wang, Shuiping Lu, Mingzhong Wang, Xiaobing Zhang, Jing Sun, Hui Yao   +10 more
doaj   +1 more source

Cerebellar c9RAN proteins associate with clinical and neuropathological characteristics of C9ORF72 repeat expansion carriers. [PDF]

, 2015
Clinical and neuropathological characteristics associated with G4C2 repeat expansions in chromosome 9 open reading frame 72 (C9ORF72), the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia, are highly variable ...
Bieniek, Kevin F, Boeve, Bradley F, Boylan, Kevin B, Castanedes-Casey, Monica, Cleveland, Don W, Crook, Julia E, Daughrity, Lillian M, Desaro, Pamela, Dickson, Dennis W, Edbauer, Dieter, Gendron, Tania F, Graff-Radford, Neill R, Jiang, Jie, Josephs, Keith A, Knopman, David S, Lagier-Tourenne, Clotilde, Lucas, John A, Murray, Melissa E, Overstreet, Karen, Parisi, Joseph E, Pedraza, Otto, Petersen, Ronald C, Petrucelli, Leonard, Rademakers, Rosa, Robertson, Amelia, Rousseau, Linda, Rush, Beth K, Thomas, Colleen S, van Blitterswijk, Marka   +28 more
core   +2 more sources

Prediction and verification of the AD-FTLD common pathomechanism based on dynamic molecular network analysis

Communications Biology, 2021
Jin et al use dynamic molecular network analysis to characterise the phosphoproteome in mouse models of neurodegenerative disease. Analyzing four models of frontotemporal lobar degeneration and four models of Alzheimer’s disease, they observe conserved ...
Meihua Jin, Xiaocen Jin, Hidenori Homma, Kyota Fujita, Hikari Tanaka, Shigeo Murayama, Hiroyasu Akatsu, Kazuhiko Tagawa, Hitoshi Okazawa   +8 more
doaj   +1 more source