Results 41 to 50 of about 30,886 (249)

Rates of lobar atrophy in asymptomatic MAPT mutation carriers. [PDF]

, 2019
IntroductionThe aim of this study was to investigate the rates of lobar atrophy in the asymptomatic microtubule-associated protein tau (MAPT) mutation carriers.MethodsMAPT mutation carriers (n = 14; 10 asymptomatic, 4 converters from ...
Boeve, Bradley F, Boxer, Adam L, Brushaber, Danielle, Chen, Qin, Dheel, Christina, Fields, Julie, Forsberg, Leah, Gavrilova, Ralitza, Gearhart, Debra, Graff-Radford, Jonathan, Graff-Radford, Neill R, Jack, Clifford R, Jones, David T, Kantarci, Kejal, Knopman, David S, Kremers, Walter K, Lapid, Maria, LEFFTDS Consortium, Lesnick, Timothy G, Rademakers, Rosa, Rosen, Howie, Senjem, Matthew, Syrjanen, Jeremy, Tosakulwong, Nirubol, Wszolek, Zbigniew K   +24 more
core   +2 more sources

GABA and glutamate deficits from frontotemporal lobar degeneration are associated with disinhibition

Brain : a journal of neurology, 2020
Murley et al. use ultra-high field (7T) magnetic resonance spectroscopy to measure in vivo glutamate and GABA in frontotemporal lobar degeneration syndromes, and show that deficits in these neurotransmitters are associated with behavioural disinhibition.
A. Murley, A. Murley, M. Rouse, P. Jones, R. Ye, F. Hezemans, F. Hezemans, C. O’Callaghan, Polytimi Frangou, Z. Kourtzi, C. Rua, T. Carpenter, C. Rodgers, J. Rowe, J. Rowe, J. Rowe   +15 more
semanticscholar   +1 more source

Predictors of survival in frontotemporal lobar degeneration syndromes

Journal of Neurology Neurosurgery & Psychiatry, 2021
After decades of research, large-scale clinical trials in patients diagnosed with frontotemporal lobar degeneration (FTLD) are now underway across multiple centres worldwide.
Shadi El-Wahsh, E. Finger, O. Piguet, V. Mok, J. Rohrer, M. Kiernan, R. Ahmed   +6 more
semanticscholar   +1 more source

Asymmetrical Lobar Degenerations: Clinical, Neuropsychological, Scanning Data [PDF]

Türk Nöroloji Dergisi, 2006
OBJECTIVE: Asymmetric lobar degenerations are clinical syndromes which affect primarily one or more than one cerebral lobe and result progressive language and/or behaviour and/or cognitive dysfunction.
İpek Midi, Tülin Tanrıdağ, Aynur Mollahasanoğlu, Özen Çatan, Önder Us   +4 more
doaj  

Frontotemporal Lobar Degeneration and microRNAs

Frontiers in Aging Neuroscience, 2016
Frontotemporal lobar degeneration (FTLD) includes a spectrum of disorders characterized by changes of personality and social behaviour and, often, a gradual and progressive language dysfunction.
Paola ePiscopo, DIEGO eALBANI, Anna Elisa eCastellano, Gianluigi eForloni, Annamaria eConfaloni   +4 more
doaj   +1 more source

Human Ubiquilin 2 and TDP-43 copathology drives neurodegeneration in transgenic Caenorhabditis elegans

G3: Genes, Genomes, Genetics, 2021
Amyotrophic lateral sclerosis (ALS) is a debilitating, fatal neurodegenerative disease that causes rapid muscle wasting. It shares a spectrum of symptoms and pathology with frontotemporal lobar degeneration (FTLD).
Aleen D Saxton, Brian C Kraemer
doaj   +1 more source

Limbic-predominant age-related TDP-43 encephalopathy differs from frontotemporal lobar degeneration.

Brain : a journal of neurology, 2020
TAR-DNA binding protein-43 (TDP-43) proteinopathy is seen in multiple brain diseases. A standardized terminology was recommended recently for common age-related TDP-43 proteinopathy: limbic-predominant, age-related TDP-43 encephalopathy (LATE) and the ...
John L. Robinson, S. Porta, Filip G. Garrett, Panpan Zhang, S. Xie, Eunran Suh, V. V. Van Deerlin, E. Abner, G. Jicha, Justin M Barber, V. Lee, Eddie B. Lee, J. Trojanowski, P. Nelson   +13 more
semanticscholar   +1 more source

Old age genetically confirmed frontotemporal lobar degeneration with TDP‐43 has limbic predominant TDP‐43 deposition

Neuropathology and Applied Neurobiology, 2021
To assess the burden of transactive response DNA‐binding protein of 43 kDa (TDP‐43) inclusions in a unique cohort of old‐age patients with genetic frontotemporal lobar degeneration (gFTLD‐TDP) and compare these patients with sporadic old‐age individuals ...
Marina Buciuc, J. Whitwell, M. Baker, R. Rademakers, D. Dickson, K. Josephs   +5 more
semanticscholar   +1 more source

Clinical, Genetic and Neuropathological Features of Frontotemporal Dementia: An Update and Guide

Acta Médica Portuguesa, 2013
Introduction: Frontotemporal Lobar Degeneration encompasses a group of heterogeneous disorders with shared behavioural and cognitive symptoms, as well as gross pathological features.
Jorge Pelicano Paulos, João Massano
doaj   +1 more source

Hexanucleotide Repeat Expansion in C9ORF72 Is Not Detected in the Treatment-Resistant Schizophrenia Patients of Chinese Han. [PDF]

PLoS ONE, 2015
Hexanucleotide (GGGGCC) repeat expansion in C9ORF72 (HRE) causes frontotemporal lobar degeneration, frontotemporal dementia-amyotrophic lateral sclerosis, and amyotrophic lateral sclerosis.
Xijia Xu, Shiping Xie, Xiaomeng Shi, Jie Lv, Xiaowei Tang, Xiaolan Wang, Shuiping Lu, Mingzhong Wang, Xiaobing Zhang, Jing Sun, Hui Yao   +10 more
doaj   +1 more source