Results 71 to 80 of about 30,886 (249)

[18F]AV-1451 binding in vivo mirrors the expected distribution of TDP-43 pathology in the semantic variant of primary progressive aphasia [PDF]

, 2018
Introduction Semantic dementia, including the semantic variant of primary progressive aphasia (svPPA), is strongly associated with TAR-DNA binding protein 43 (TDP-43) type C pathology.
Aigbirhio, Franklin, Allinson, KSJ, Arnold, R, Bevan-Jones, William, Coles, Jonathan, Cope, Thomas, Fryer, Timothy, Hong, Young, Jones, Simon, O'Brien, John, Passamonti, Luca, Patterson, Karalyn, Rowe, James   +12 more
core   +1 more source

Anatomical Associations Between Focal Mitochondrial Metabolism and Patterns of Neurodegeneration in Amyotrophic Lateral Sclerosis

Annals of Neurology, EarlyView.
Objective Amyotrophic lateral sclerosis (ALS) has a very specific neuroimaging signature, but the molecular underpinnings of the strikingly selective anatomic involvement have not elucidated to date. Accordingly, a large neuroimaging study was conducted with 258 participants to evaluate associations between patterns of neurodegeneration and focal ...
Marlene Tahedl, We Fong Siah, Efstratios Karavasilis, Jennifer C. Hengeveld, Mark A. Doherty, Russell L. McLaughlin, Orla Hardiman, Ee Ling Tan, Foteini Christidi, Jana Kleinerova, Peter Bede   +10 more
wiley   +1 more source

A Case of Frontotemporal Dementia with Epilepsia Partialis Continua Responding to Lacosamide Treatment

Archives of Epilepsy, 2019
Seizures may occur in frontotemporal lobar degeneration syndromes as an element of a heterogeneous group of disorders, according to both clinical phenotype and neuropathology.
Yasemin DİNÇ, Gönül ÇELİK AKDAĞ
doaj   +1 more source

DNA methylation as a contributor to dysregulation of STX6 and other frontotemporal lobar degeneration genetic risk-associated loci

Rambarack N, Fodder K, Murthy M, Toomey C, de Silva R, Humphrey J, Raj T, Lashley T, Bettencourt C.   +8 more
europepmc   +2 more sources

Prospective memory impairments in Alzheimer's Disease and behavioral variant frontotemporal dementia: Clinical and neural correlates [PDF]

, 2016
BACKGROUND: Prospective memory (PM) refers to a future-oriented form of memory in which the individual must remember to execute an intended action either at a future point in time (Time-based) or in response to a specific event (Event-based).
Addis, Ashburner, Berlin, Braak, Burgess, Burgess, Burgess, Cona, Costa, Costa, de Toledo-Morrell, Dhanjal, d’Ydewalle, Einstein, Frisch, Giannakopoulos, Gilbert, Hornberger, Irish, Irish, Irish, Irish, Irish, Irish, Irish, Irish, Jones, Kamminga, Karas, Martin, Martins, McDaniel, McDaniel, McKhann, Mechelli, Mioshi, Mioshi, Morris, Nichols, Okuda, Pennington, Pirogovsky, Poppenk, Rascovsky, Reitan, Rey, Rosen, Rueckert, Saur, Savage, Schmidt, Schroeter, Seeley, Seghier, Sellitto, Smith, Smith, Spreng, Söderlund, Umeda, van den Berg, Volle, Wechsler, Wedderburn, Wiener   +64 more
core   +1 more source

A Novel α‐Synuclein K58N Missense Variant in a Patient with Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Parkinson's disease (PD) is a complex multifactorial disorder with a genetic component in about 15% of cases. Multiplications and point mutations in SNCA gene, encoding α‐synuclein (aSyn), are linked to rare familial forms of PD. Objective Our goal was to assess the clinical presentation and the biological effects of a novel K58N ...
Mohammed Al‐Azzani, Sandrina Weber, Nagendran Ramalingam, Maria Ramón, Liana Shvachiy, Gonçalo Mestre, Michael Zech, Kevin Sicking, Alain Ibáñez de Opakua, Vidyashree Jayanthi, Leslie Amaral, Aishwarya Agarwal, Aswathy Chandran, Susana R. Chaves, Juliane Winkelmann, Claudia Trenkwalder, Maike Schwager, Silke Pauli, Ulf Dettmer, Claudio O. Fernández, Janin Lautenschläger, Markus Zweckstetter, Ruben Fernandez‐Busnadiego, Brit Mollenhauer, Tiago Fleming Outeiro   +24 more
wiley   +1 more source

Clinical Characteristics of C9ORF72-Linked Frontotemporal Lobar Degeneration

Dementia and Geriatric Cognitive Disorders Extra, 2013
Background: The most common genetic cause of frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) has been linked to a hexanucleotide repeat expansion in the C9ORF72 gene.
Anna-Lotta Kaivorinne, Michaela K. Bode, Liisa Paavola, Hannu Tuominen, Mika Kallio, Alan E. Renton, Bryan J. Traynor, Virpi Moilanen, Anne M. Remes   +8 more
doaj   +1 more source

The neuroanatomical and neurochemical basis of apathy and impulsivity in frontotemporal lobar degeneration. [PDF]

, 2018
Apathy and impulsivity are common and often coexistent consequences of frontotemporal lobar degeneration (FTLD). They increase patient morbidity and carer distress, but remain under-estimated and poorly treated.
Lansdall, CJ, Passamonti, L, Rowe, JB
core   +1 more source

Redefining the multidimensional clinical phenotypes of frontotemporal lobar degeneration syndromes

Brain : a journal of neurology, 2019
See Piguet (doi:10.1093/brain/awaa119) for a scientific commentary on this article. Murley et al. report the results of a transdiagnostic study of clinical phenotype and brain atrophy in frontotemporal lobar degeneration syndromes, showing that these ...
A. Murley, I. Coyle-Gilchrist, M. Rouse, P. Jones, Win-Yin Li, J. Wiggins, C. Lansdall, Patricia Vázquez Rodríguez, A. Wilcox, K. Tsvetanov, K. Patterson, M. L. Lambon Ralph, J. Rowe   +12 more
semanticscholar   +1 more source

A novel SNCA E83Q mutation in a case of dementia with Lewy bodies and atypical frontotemporal lobar degeneration

Neuropathology (Kyoto. 1993), 2020
In this case report, we discuss a patient presenting with parkinsonism followed by a non‐amnestic dementia with aphasic clinical features, as well as frontal dysexecutive syndrome. There was a family history of dementia with an autopsy diagnosis of “Pick'
A. Kapasi, J. Brosch, K. Nudelman, S. Agrawal, T. Foroud, J. Schneider   +5 more
semanticscholar   +1 more source