Results 31 to 40 of about 672,406 (301)
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Scientific ReportsThe central amygdala (CeA) is a crucial hub in the processing of affective itch, containing a diverse array of neuronal populations. Among these components, Neuropeptide Y (NPY) and its receptors, such as NPY2R, affect various physiological and ...
Darya Pavlenko +7 more
doaj +1 more source
Agronomy, 2021 This study compares yield, nutritive value, and kernel properties of whole plant corn (WPC) harvested before and after a light frost in short growing season areas.
Jessie Guyader +2 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Melanoma on Chronically Sun-Damaged Skin: Deciphering Gene Expression Signatures
Dermatology Practical & ConceptualIntroduction: Melanoma of the skin is responsible for most skin cancer-related deaths. It is well known that exposure to ultraviolet radiation is the most common and modifiable risk factor for melanoma. Melanomas arising on chronically sun-damaged skin
Alejandra Avila +9 more
doaj +1 more source
Agriculture, 2021 Pseudomonas syringae causes bacterial blight (BB) disease worldwide on economically important fruit and vegetable crops including field pea (Pisum sativum L.). The two pathovars responsible for BB in field pea are Pseudomonas syringae pathovar pisi (Psp)
Pragya Kant +5 more
doaj +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Integration of a Frost Mortality Scheme Into the Demographic Vegetation Model FATES
Journal of Advances in Modeling Earth Systems, 2023 Frost is damaging to plants when air temperature drops below their tolerance threshold. The set of mechanisms used by cold‐tolerant plants to withstand freezing is called “hardening” and typically take place in autumn to protect against winter damage ...
Marius S. A. Lambert +7 more
doaj +1 more source
A Review of Methods and Techniques for Detecting Frost on Plant Surfaces
Agriculture, 2021 Severe frost usually has adverse impacts on agricultural production, resulting in crop freeze injury, poor crop yield, and crop quality reduction. Timely and accurate detection of frost plays an important role in cold damage warnings, prevention, and ...
Huan Song +5 more
doaj +1 more source