Results 91 to 100 of about 2,516,152 (276)

The GPX3‐VCAM1 Axis Gates Pro‐Fibrotic Tubule Cell Fate in Hyperuricemic Nephropathy

Advanced Science, EarlyView.
Hyperuricemia induces NLRP3 inflammasome signaling activation and downregulation of GPX3 in proximal tubular epithelial cells, leading to oxidative stress–driven VCAM1 upregulation, emergence of pro‐fibrotic proximal tubule cells, macrophage recruitment, and renal fibrosis.
Yunfei Qi, Qiang Zhao, Yue Lve, Yaming Yuan, Tingting Zhou, Yue Yuan, Dexi Wu, Yifan Tang, Yan Liu, Zhigang Li, Chunping Jiang, Qiurong Ding   +11 more
wiley   +1 more source

Comparative Outcomes of Day 3 and Day 5 Frozen–Thawed Embryo Transfers: A Retrospective Clinical Study

Biomedicines
Aim: This study aimed to compare the clinical pregnancy outcomes of Day 3 (cleavage-stage) and Day 5 (blastocyst) frozen–thawed embryo transfers in assisted reproductive technology (ART) cycles.
Fatma Kılıç Hamzaoğlu, Serdar Dilbaz, Runa Özelçi, Onur Kaya, Emine Utlu Özen   +4 more
doaj   +1 more source

Palmitoyl Acyltransferase Zdhhc17 Promotes Functional Recovery After Spinal Cord Injury by Targeting the Nuclear Transport Factors Kpna2 and Ipo9

Advanced Science, EarlyView.
In this study, we demonstrate that Zdhhc17, acting as a PAT, suppresses neuronal apoptosis and promotes axon regeneration after injury, thereby enhancing functional recovery following SCI. In this context, Kpna2 and Ipo9 serve as novel palmitoylation substrates of Zdhhc17, whose palmitoylation prevents the injury‐induced degradation of their proteins ...
Meixuan Chen, Huan Chen, Sining Ding, Fan Liu, Xiaofei Zheng, Yuan Wang, Ruitu Tian, Huan Li, Peilin Liu, Le Hu, Bin Liu, Limin Rong, Mangmang Li   +12 more
wiley   +1 more source

Impact of serum luteinizing hormone level and increment on the day of endometrial transformation on frozen–thawed single blastocyst transfer outcome in the hormone replacement cycle

Journal of Ovarian Research
Objective To analyze the effect of serum luteinizing hormone (LH) level and increment on the day of endometrial transformation on the outcome of frozen-thawed embryo transfer during the hormone replacement cycle.
Kang Yu, Junhong Zhou, Jing Ju, Ailing Han   +3 more
doaj   +1 more source

Advanced age woman with diminished ovarian reserve obtained live birth following a zero pronuclei-derived four-cell frozen-thawed embryo transfer on day 4: a case report

Frontiers in Medicine
ObjectiveAdvanced maternal age and diminished ovarian reserve (DOR) are challenges in infertile patients for in vitro fertilization-embryo transfer (IVF-ET).
Xiao-lei Zhang, Yong-qian Chen, Ya-juan Zhang   +2 more
doaj   +1 more source

Endowing Flexibility of Alveolar Type II Cells to Recapitulate Development From Lung Bud to Alveoli

Advanced Science, EarlyView.
Adult human alveolar type 2 cells are chemically reprogrammed into expandable alveolar progenitor‐like cells that acquire bud tip‐like features during expansion and form organoids that mature into alveolar‐like structures. These organoids model influenza A virus infection and innate immune responses in vitro, while transplanted cells engraft ...
Hongqian Ma, Yuxin Zhang, Lujia Sun, Hong Jiang, Fan Li, Wenming Liu, Shenao Zhou, Mengting Wang, Weijian Huang, Xu Zhou, Caiyang Chen, Qiuqiu Zhang, Xiaoyan Jin, Feihan Yan, Hongping Wu, Yonghong Yin, Xinling Wang, Hexin Yan, Weifeng Yu   +18 more
wiley   +1 more source

Outcome of cryopreserved-thawed embryo transfer in the GnRH agonist versus antagonist protocol [PDF]

, 2013
Background: GnRH agonist and antagonist were developed to control the premature release of LH surge. There is some difference between two protocols. Objective: We compared the outcome of frozen-thawed embryo transfer in infertile women who used GnRH ...
Karimi, Hesamoddin, Firouzabadi, Razieh Dehghani, Eftekhar, Maryam, Rahmani, Elham   +3 more
core   +1 more source

Acid‐Responsive Nanobot‐Integrated Core‐Shell Microneedles Reprogram the Degenerative Annulus Fibrosus Microenvironment Through Epigenetic Suppression of Ferroptosis

Advanced Science, EarlyView.
An acid‐responsive core‐shell microneedle system normalizes the degenerative annulus fibrosus microenvironment by consuming pathological H+, generating O2, and providing NIR‐amplified redox buffering. Mechanistically, it epigenetically suppresses ferroptosis via DNMT3A‐dependent methylation of the ATF3 promoter, relieving ATF3‐mediated repression of ...
Lu Tan, Yan Zheng, Yue Lan, Zhuo Cheng, Siya Wang, Changqing Li, Yanqiu Wang, Minghan Liu   +7 more
wiley   +1 more source

Live birth after frozen-thawed embryo transfer: which endometrial preparation protocol is better?

, 2020
Objective: To compare the clinical outcomes of modified natural cycle (mNC) and artificial cycle (AC) protocols for frozen embryo transfers. Material and methods: A total of 490 frozen-thawed autologous embryo transfer cycles, performed in a single ...
Goker, Ege Nazan Tavmergen, Calimlioglu, Nilufer, Meseri, Reci, Tavmergen, Erol, Acet, Ferruh, Sahin, Gulnaz   +5 more
core   +1 more source

Developmentally Guided Differentiation of Ventral Midbrain Dopaminergic Cells Validated in Proteopathy‐Based Parkinson's Disease Models

Advanced Science, EarlyView.
A developmentally guided protocol reproducibly specifies EN1‐positive ventral midbrain dopaminergic (vmDA) progenitors from human pluripotent stem cells and yields functional vmDA neurons. Optogenetic induction of α‐synuclein aggregation elicits selective degeneration of TH‐positive neurons in 2D cultures and 3D neurospheroids, while transplanted ...
Heechang Moon, Heejeong Kim, Elliot H. Lee, Hanseul Kim, Ji Hun Kim, Huisu Jeong, Jiwon Cheon, Ga Ram Jeong, Byoung Dae Lee, Jae‐Won Cho, Soo‐Jin Oh, Yunjong Lee, Yohan Oh   +12 more
wiley   +1 more source