Results 71 to 80 of about 2,389,697 (294)

Increasing vaginal progesterone gel supplementation after frozen-thawed embryo transfer significantly increases the delivery rate

, 2012
The aim of this study was to evaluate the reproductive outcome in patients receiving frozen-thawed embryo transfer before and after doubling of the vaginal progesterone gel supplementation.
Povlsen, Betina Boel, Humaidan, Peter, Polyzos, Nikolaos P, Alsbjerg, Birgit, Andersen, Claus Yding, Elbaek, Helle Olesen   +5 more
core   +1 more source

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

Nuclear transfer in the bovine embryo: A comparison of 5‐day, 6‐day, frozen‐thawed, and nuclear transfer donor embryos

, 1991
Micromanipulation and electrofusion were utilized for nuclear transfer in bovine embryos. Embryonic blastomeres from 5‐day (estrus = day 0), 6‐day, frozen‐thawed 5‐day, and first‐generation nuclear transfer embryos (embryos were themselves a product of ...
K. R. Bondioli, J. H. Pryor, M. E. Westhusin, Westhusin, M. E., Pryor, J. H., Bondioli, K. R.   +5 more
core   +1 more source

Reorganization of Innate Immune Cell Lipid Profiles by Bioinspired Meroterpenoids to Limit Inflammation

Advanced Science, EarlyView.
Resolution pharmacology is an emerging strategy to tackle inflammatory pathologies. Bioinspired meroterpenoids induce a lipid mediator class switch toward inflammation resolution in vitro and in vivo by targeting key nodes in lipid mediator biosynthesis and neutral lipid dynamics.
Lorenz Waltl, David Holubek, Klaus Speck, Raphael Wildermuth, Franz‐Lucas Haut, Stephan Permann, Immanuel Plangger, Christian Steinborn, Zhigang Rao, Danilo D'Avino, Ida Cerqua, Julia Stadler, Fiorentina Roviezzo, Peter Schlenke, Anita Siller, Harald Schennach, Solveigh C. Koeberle, Eva‐Maria Pferschy‐Wenzig, Antonietta Rossi, Thomas Magauer, Andreas Koeberle   +20 more
wiley   +1 more source

High‐Dose Hormone Replacement Therapy Improved Embryo Transfer Outcomes in a Woman With 21‐Hydroxylase Deficiency Who Had Persistently High Serum Progesterone Levels: A Case Report and Literature Review

Clinical Case Reports
Women with 21‐hydroxylase deficiency have reduced fertility because of excessive production of adrenal androgen and progesterone, which can inhibit folliculogenesis, disturb the normal gonadotropin secretion pattern and development of the endometrium ...
Yuri Mizusawa, Hiroaki Shibahara, Masahide Shiotani   +2 more
doaj   +1 more source

Clinical utility of chlormadinone acetate (Lutoral™) in frozen‐thawed embryo transfer with hormone replacement

Reproductive Medicine and Biology, 2019
Purpose The clinical utility of chlormadinone acetate tablets (Lutoral™), an orally active progestin which has been available since June 2007, was compared to an in‐house vaginal suppository formulation of progesterone used between 2006 and 2007 for ...
Yoshimasa Asada, Yoshiki Hashiba, Yukio Hattori, Daichi Inoue, Rie Ito, Noritaka Fukunaga, Megumi Sonohara   +6 more
doaj   +1 more source

They Can't Have My Embryo: The Ethics of Conditional Embryo Donation [PDF]

, 2013
There are substantial numbers of frozen embryos in storage that will not be used by those who produced them for their own fertility treatment. One option for such embryos is to donate them to others to use in their fertility treatment.
Eric Blyth, Lucy Frith, Frith, Lucy; id_orcid, Blyth, Eric, Frith, Lucy   +4 more
core   +1 more source

Targeting Tex10 Overcomes Oxaliplatin Resistance by Competitively Disrupting the Non‐Canonical BAF Complex in Colorectal Cancer

Advanced Science, EarlyView.
This study reveals that Tex10 drives oxaliplatin resistance in colorectal cancer by competitively binding BRD9 to disrupt the ncBAF complex, thereby suppressing AMBRA1 transcription and ULK1‐mediated autophagy. Gemcitabine is identified as a direct Tex10 inhibitor that restores autophagy and overcomes resistance.
Ping Xu, Jie Huang, Xiaojin Gao, Lin Deng, Yanheng Deng, Denglu Wang, Chunlei Yu, Yunxiang Zhang, Jingdong Li, Xiaocong Xiang   +9 more
wiley   +1 more source

PCOS patients; how the endometrium can be ready for frozen embryo transfer? A retrospective study

Middle East Fertility Society Journal, 2018
Study objective: Frozen-thawed embryo transfer (FET) avoids the nightmare of developing ovarian hyperstimulation syndrome in PCOS patients during IVF. Ideal protocols of Endometrium preparation in PCOS patients are lacking and need further declaration ...
Alaa Wageh, Muhammad Fawzy
doaj   +1 more source

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source