Results 71 to 80 of about 12,356 (220)

Clinical utility of chlormadinone acetate (Lutoral™) in frozen‐thawed embryo transfer with hormone replacement

Reproductive Medicine and Biology, 2019
Purpose The clinical utility of chlormadinone acetate tablets (Lutoral™), an orally active progestin which has been available since June 2007, was compared to an in‐house vaginal suppository formulation of progesterone used between 2006 and 2007 for ...
Yoshimasa Asada, Yoshiki Hashiba, Yukio Hattori, Daichi Inoue, Rie Ito, Noritaka Fukunaga, Megumi Sonohara   +6 more
doaj   +1 more source

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

Advanced Science, EarlyView.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon, Mireille Elodie Tsitokana, Ugo Guy Alenda, Yen‐Ling Lian, Clémentine Eva Philibert, Mathieu Oosterlaken, Marta Cimadevila, Gaëlle Dudon, Jessica Monnic, Salomé Roux, Julie Bessié, Séverine Diem, Franck Vandermoere, Laurent Prézeau, Patrick Chames, Julie Kniazeff, Sylvie Claeysen, Anaïs Menny, Jean‐Philippe Pin, Véronique Perrier, Jianfeng Liu, Philippe Rondard   +21 more
wiley   +1 more source

PCOS patients; how the endometrium can be ready for frozen embryo transfer? A retrospective study

Middle East Fertility Society Journal, 2018
Study objective: Frozen-thawed embryo transfer (FET) avoids the nightmare of developing ovarian hyperstimulation syndrome in PCOS patients during IVF. Ideal protocols of Endometrium preparation in PCOS patients are lacking and need further declaration ...
Alaa Wageh, Muhammad Fawzy
doaj   +1 more source

WTAP‐Mediated m6A Modification Targets the LRP1‐Lipid Metabolism Axis to Regulate Joint Cartilage Regeneration

Advanced Science, EarlyView.
WTAP drives cartilage regeneration by activating an LRP1‐dependent lipid metabolic program in macrophages, enhancing IL‐10 and TGF‐β secretion to promote chondrogenic differentiation. Leveraging this mechanism, virtual screening identifies LRP1‐targeting compounds that effectively stimulate cartilage repair, highlighting a druggable epigenetic ...
Chenyan Huang, Chenyu Deng, Zhengrong Gao, Chen Chen, Huimin Zheng, Yue Yang, Yan Wei   +6 more
wiley   +1 more source

The impact of endometrial thickness change after progesterone administration on pregnancy outcome in patients transferred with single frozen-thawed blastocyst

Reproductive Biology and Endocrinology, 2019
Background The aim of this study was to explore the impact of endometrial thickness change after progesterone administration on pregnancy outcome in patients transferred with single frozen-thawed blastocyst.
Zhiqin Bu, Xinhong Yang, Lin Song, Beijia Kang, Yingpu Sun   +4 more
doaj   +1 more source

Hair Follicle Seedling Cryomicroneedles from Hierarchical Microfluidic Organoid on a Chip

Advanced Science, EarlyView.
In this paper, a hierarchical microfluidic chip is developed to produce uniform hair follicle organoids (HFOs) in cryomicroneedles. Cryopreservation agents encapsulate HFOs, preserving viability and hair growth potential. The cryomicroneedles enable simple intradermal transplantation with good skin penetration.
Xinyue Cao, Dongyu Xu, Minhui Lu, Yuanjin Zhao   +3 more
wiley   +1 more source

Clinical aspects of embryo implantation: from the perspective of tissue perfusion.

, 2006
Hypothesis: Pelvic perfusion is the pivotal factor for the outcome of in vitro fertilisation (IVF) treatment once clinical and embryological variables are controlled for their effect.;Demonstration of Hypothesis: In a series of three studies, the ...
Ozturk, O., Ozturk, Ozkan
core  

A Brain‐Penetrant Nanobody Reveals GSK3β‐Driven Proline‐Directed Phosphorylation as a Master Regulator of Ischemic Neurodegeneration

Advanced Science, EarlyView.
A brain‐targeted nanoparticle enables delivery of a therapeutic nanobody (Nb.29E9) that inhibits pathogenic GSK3β signaling. This intervention restores AMPK/mTORC1/TGFβ homeostasis, attenuates neuroinflammation and oxidative stress, and promotes long‐term functional recovery after ischemic stroke.
Lan Li, Muyang Li, Lei Sun, Ying Yang, Yuanshun Wu, Ziyi Yin, Anni Wang, Peiyang Zhou, Shaoxiang Luo, Jian Chen, Jun Qin, Zhibing Ai, Zilong Yuan, Zhiqiang Dong, Min Zhang   +14 more
wiley   +1 more source

The effect of elevated progesterone levels before HCG triggering in modified natural cycle frozen-thawed embryo transfer cycles

, 2017
Recent studies suggest that elevated late follicular phase progesterone concentrations after ovarian stimulation for IVF may result in embryo–endometrial asynchrony, reducing the chance of successful implantation after fresh embryo transfer.
Amani Al-Oraiby, Spinder, Taeke, Nick S. Macklon, A. Petra Manger, Diederik A. Hoozemans, Carolina A.M. Koks, Mariëtte Goddijn, Laven, Joop S E, Manger, Petra A P, Jan-Peter de Bruin, Hoek, Annemieke, Hoozemans, Diederik A., Egbert A. Brinkhuis, Paul J.Q. van der Linden, Minouche van Rumpste, van Rumpste, Minouche, Fleisher, Kathrin, Macklon, Nick S., Kaaijk, Eugenie M, Friederich, Jaap, Al-Oraiby, Amani, ANTARCTICA Study Group, Frank J.M. Broekmans, Cohlen, Ben J., Groenewoud, Eva R., Brinkhuis, Egbert A., de Bruin, Jan Peter, Jaap Friederich, Joop S.E. Laven, van der Dool, Grada, Eva R. Groenewoud, Kathrin Fleisher, van der Linden, Paul J.Q., Ben J. Cohlen, Koks, Carolina A.M., Eugenie M. Kaaijk, Broekmans, Frank J.M., Goddijn, Mariëtte, Grada van der Dool, Annemieke Hoek, Taeke Spinder   +40 more
core   +4 more sources

Sequential embryo transfer combined with intrauterine perfusion improved pregnancy outcomes in patients with recurrent implantation failure

BMC Women's Health
Objective To compare the application of sequential embryo transfer, cleavage embryo transfer, and blastocyst transfer combined with intrauterine perfusion in frozen–thawed embryo transfer cycles in patients with recurrent implantation failure to provide ...
Wenda Zou, Dan Liu, Juan Peng, Zhijing Tang, Yukun Li, Juan Zhang, Ziwei Liu   +6 more
doaj   +1 more source