Results 51 to 60 of about 12,356 (220)

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source

Clinical application of noninvasive chromosomal screening for elective single-blastocyst transfer in frozen-thawed cycles

Journal of Translational Medicine, 2022
Background The objective of this study was to explore the clinical application of noninvasive chromosomal screening (NICS) for elective single-blastocyst transfer (eSBT) in frozen-thawed cycles. Methods This study retrospectively analysed the data of 212
Rui Chen, Ni Tang, Hongzi Du, Yaxin Yao, Yangyun Zou, Jing Wang, Dunmei Zhao, Xueliang Zhou, Yang Luo, Lei Li, Yuling Mao   +10 more
doaj   +1 more source

Increasing vaginal progesterone gel supplementation after frozen-thawed embryo transfer significantly increases the delivery rate

, 2012
The aim of this study was to evaluate the reproductive outcome in patients receiving frozen-thawed embryo transfer before and after doubling of the vaginal progesterone gel supplementation.
Povlsen, Betina Boel, Humaidan, Peter, Polyzos, Nikolaos P, Alsbjerg, Birgit, Andersen, Claus Yding, Elbaek, Helle Olesen   +5 more
core   +1 more source

They Can't Have My Embryo: The Ethics of Conditional Embryo Donation [PDF]

, 2013
There are substantial numbers of frozen embryos in storage that will not be used by those who produced them for their own fertility treatment. One option for such embryos is to donate them to others to use in their fertility treatment.
Eric Blyth, Lucy Frith, Frith, Lucy; id_orcid, Blyth, Eric, Frith, Lucy   +4 more
core   +1 more source

HNRNPU K181 Lactylation Drives Cervical Cancer Growth by Upregulating PHGDH and Reprogramming Serine Metabolism

Advanced Science, EarlyView.
Lactate in cervical cancer induces HNRNPU K181 lactylation, opposed by NAA50‐mediated acetylation and suppressed by Pazopanib. This lactylation enhances HNRNPU binding to PHGDH pre‐mRNA exon 1, maintaining exon 1‐containing transcripts and mRNA stability, thereby activating serine metabolism.
Chang Zhang, Qingfei Meng, Hui Jiao, Huixin Liu, Xiangchao Wang, Honglan Zhou, Yishu Wang   +6 more
wiley   +1 more source

Outcomes of different transfer strategies for in vitro fertilization/intracytoplasmic sperm injection with poor-quality embryos−Analysis of embryonic development, perinatal period, and neonatal outcomes

Heliyon
During the in vitro fertilization and embryo transfer process, some expectant mothers may not have good embryos to choose from before the embryo transfer.
Lei Jin, Zhou Li, Keyi Si, Bingxin Ma, Xinling Ren, Bo Huang   +5 more
doaj   +1 more source

Redox‐Dependent Chaperoning of GBF1 Condensates Regulates Seed Germination in Arabidopsis

Advanced Science, EarlyView.
In dormant seeds (low ROS), GBF1 forms liquid condensates to repress the germination gene CathB3, and the chaperone GIP1 maintains condensate liquidity and repressive activity. Upon imbibition (high ROS), ROS oxidize GIP1 during germination, impairing its chaperone function.
Yunying Wang, Xiaofeng Fang
wiley   +1 more source

REPRODUCTIVE OUTCOMES FOLLOWING FROZEN-THAWED EMBRYO TRANSFER IS SUPERIOR WITH THE TRANSFER OF BLASTOCYSTS EXPANDED ON DAY 5 THAN ON DAY 6

International Journal of Health Services Research and Policy, 2021
To compare pregnancy and live birth rates between D5 and D6 transfer of frozen-thawed blastocysts in women undergoing ‘freeze-all’ cycles. Our study, designed as a retrospective cohort study, evaluates single frozen thaw embryo transfer in 209 patients ...
Aytek ŞIK
doaj   +1 more source

Nuclear transfer in the bovine embryo: A comparison of 5‐day, 6‐day, frozen‐thawed, and nuclear transfer donor embryos

, 1991
Micromanipulation and electrofusion were utilized for nuclear transfer in bovine embryos. Embryonic blastomeres from 5‐day (estrus = day 0), 6‐day, frozen‐thawed 5‐day, and first‐generation nuclear transfer embryos (embryos were themselves a product of ...
K. R. Bondioli, J. H. Pryor, M. E. Westhusin, Westhusin, M. E., Pryor, J. H., Bondioli, K. R.   +5 more
core   +1 more source

Progesterone supplementation in natural cycles improves live birth rates after embryo transfer of frozen-thawed embryos—a randomized controlled trial

, 2022
STUDY QUESTION: Does supplementation with vaginal tablets of progesterone after frozen-thawed embryo transfer in natural cycles improve the live birth rate?
Dahlgren Granbom, M, Wånggren, Kjell, Dahlgren Granbom, M., A Stavreus-Evers, Stavreus-Evers, Anneli, Stavreus-Evers, Anneli,, Dahlgren Granbom, M.,, Wånggren, K, S I Iliadis, K Wånggren, J Gudmundsson, Iliadis, Stavros I, Gudmundsson, J., Gudmundsson, J, M Dahlgren Granbom, Gudmundsson, J.,, Stavreus-Evers, A, Iliadis, S I, Iliadis, Stavros I,, Wånggren, Kjell,   +19 more
core   +1 more source