Results 1 to 10 of about 10,894 (204)

Multifunctional Fructose 1,6-Bisphosphate Aldolase as a Therapeutic Target [PDF]

Frontiers in Molecular Biosciences, 2021
Fructose 1,6-bisphosphate aldolase is a ubiquitous cytosolic enzyme that catalyzes the fourth step of glycolysis. Aldolases are classified into three groups: Class-I, Class-IA, and Class-II; all classes share similar structural features but low amino ...
David B. Pirovich, Akram A. Da’dara, Patrick J. Skelly   +2 more
doaj   +5 more sources

Characterization of Fructose-1,6-Bisphosphate Aldolase 1 of Echinococcus multilocularis [PDF]

Veterinary Sciences, 2021
Glycolysis is one of the important ways by which Echinococcus multilocularis acquires energy. Fructose-1, 6-bisphosphate aldolase (FBA) plays an important role in this process, but it is not fully characterized in E. multilocularis yet.
Xuedong He, Jing Zhang, Yue Sun, Tianyan Lan, Xiaola Guo, Xiaoqiang Wang, Omnia M. Kandil, Mazhar Ayaz, Xuenong Luo, Houhui Song, Yadong Zheng   +10 more
doaj   +5 more sources

Fructose‐1,6‐bisphosphate aldolase of Neisseria meningitidis binds human plasminogen via its C‐terminal lysine residue [PDF]

MicrobiologyOpen, 2016
Neisseria meningitidis is a leading cause of fatal sepsis and meningitis worldwide. As for commensal species of human neisseriae, N. meningitidis inhabits the human nasopharynx and asymptomatic colonization is ubiquitous.
Fariza Shams, Neil J. Oldfield, Si Kei Lai, Sarfraz A. Tunio, Karl G. Wooldridge, David P. J. Turner   +5 more
doaj   +7 more sources

Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK [PDF]

Nature, 2017
葡萄糖是生物中最基本、最主要的营养物质，它不仅是机体能量的主要来源，也是生物质合成的主要原料。因此，葡萄糖的水平对于生物体是极其重要的。然而，在生活中，体内葡萄糖水平的波动是十分常见的，这是因为我们不可能每时每刻都在摄入葡萄糖：睡一大觉、剧烈运动几个小时或者太忙了没时间吃饭，都会引起葡萄糖水平的显著下降。这时，机体能够触发一套有效的过程应对这类“不利情况”，其中最为关键的就是激活“代谢的核心调节”——AMPK。在葡萄糖水平下降时，被激活的AMPK能够迅速启动脂肪、蛋白质的分解代谢，关闭它们的合成代谢 ...
A Sols, AJ Morris, Alexander Gray, AW Kao, B Xiao, B Xiao, C Ritterson Lew, CG Langendorf, Chen-Song Zhang, CS Zhang, D Carling, D. Grahame Hardie, F Rago, FA Ran, FA Ross, G Kroemer, GR Steinberg, H Hu, Hai-Long Piao, Huiyong Yin, IP Salt, Jin-Wei Feng, Jiwen Cui, JS Oakhill, JW Dennis, KH Choi, L Alvarez-Erviti, M Forgac, M Lu, M Lu, M Lu, Mengqi Li, Mingjiang Zhu, MM Mihaylova, MR El-Maghrabi, PM Kelley, SA Hawley, Sheng-Cai Lin, Shu-Yong Lin, Simon A. Hawley, SV Costes, Teng Ma, Terytty Yang Li, TY Li, VP Houde, WA Wilson, Y Zhao, YL Zhang, Yu-Qing Wu, Yue Zong, Zhichao Wang, Zhiyun Ye   +51 more
core   +8 more sources

The metabolic enzyme fructose-1,6-bisphosphate aldolase acts as a transcriptional regulator in pathogenic Francisella [PDF]

Nature Communications, 2017
The enzyme fructose-bisphosphate aldolase (FBA) plays central roles in glycolysis and gluconeogenesis. Here, Ziveri et al. show that FBA of the pathogen Francisella novicida acts, in addition, as a transcriptional regulator and is important for bacterial
Jason Ziveri, Fabiola Tros, Ida Chiara Guerrera, Cerina Chhuon, Mathilde Audry, Marion Dupuis, Monique Barel, Sarantis Korniotis, Simon Fillatreau, Lara Gales, Edern Cahoreau, Alain Charbit   +11 more
doaj   +3 more sources

Fructose 1,6-Bisphosphate Aldolase, a Novel Immunogenic Surface Protein on Listeria Species. [PDF]

PLoS ONE, 2016
Listeria monocytogenes is a ubiquitous food-borne pathogen, and its presence in food or production facilities highlights the importance of surveillance.
Marcelo Mendonça, Gustavo Marçal Schmidt Garcia Moreira, Fabricio Rochedo Conceição, Michael Hust, Karla Sequeira Mendonça, Ângela Nunes Moreira, Rodrigo Correa França, Wladimir Padilha da Silva, Arun K Bhunia, José Antonio G Aleixo   +9 more
doaj   +6 more sources

Molecular characterization and immune efficacy of fructose-1,6-bisphosphate aldolase from Haemaphysalis longicornis (Acari: Ixodidae) [PDF]

Parasites & Vectors, 2023
Background Ticks are obligate hematophagous ectoparasites that transmit a variety of pathogens to humans, wildlife and domestic animals. Vaccination is an effective and environmentally friendly method for tick control. Fructose-1,6-bisphosphate aldolase (
Yuan-Yuan Cao, Shu-Wen Xiao, Feng Yang, Xiao-Ya Liu, Hui Lu, Jin-Cheng Zhang, Yong-Hong Hu   +6 more
doaj   +2 more sources

Cloning and Characterization of Fructose-1,6-Bisphosphate Aldolase from Euphausia superba. [PDF]

Int J Mol Sci, 2022
Fructose-1,6-bisphosphate aldolase (EC 4.1.2.13) is a highly conserved enzyme that is involved in glycolysis and gluconeogenesis. In this study, we cloned the fructose-1,6-bisphosphate aldolase gene from Euphausia superba (EsFBA). The full-length cDNA sequence of EsFBA is 1098 bp long and encodes a 365-amino-acid protein.
Xia J, Xin W, Wang F, Xie W, Liu Y, Xu J.   +5 more
europepmc   +3 more sources

Structure of Toxoplasma gondii fructose-1,6-bisphosphate aldolase. [PDF]

Acta Crystallogr F Struct Biol Commun, 2014
The apicomplexan parasiteToxoplasma gondiimust invade host cells to continue its lifecycle. It invades different cell types using an actomyosin motor that is connected to extracellular adhesinsviathe bridging protein fructose-1,6-bisphosphate aldolase.
Boucher LE, Bosch J.
europepmc   +4 more sources

In silico study of 4-phosphorylated derivatives of 1,3-oxazole as inhibitors of Candida albicans fructose-1,6-bisphosphate aldolase II [PDF]

Heliyon, 2019
In this study, the synthesis, in vitro anti-Candida activity and molecular modeling of 4-phosphorylated derivatives of 1,3-oxazole as inhibitors of Candida albicans fructose-1,6-bisphosphate aldolase (FBA-II) are demonstrated and discussed.
Ivan V. Semenyuta, Oleksandr L. Kobzar, Diana M. Hodyna, Volodymyr S. Brovarets, Larysa O. Metelytsia   +4 more
doaj   +2 more sources