Results 101 to 110 of about 21,838 (240)

Formal executable descriptions of biological systems [PDF]

, 2005
The similarities between systems of living entities and systems of concurrent processes may support biological experiments in silico. Process calculi offer a formal framework to describe biological systems, as well as to analyse their behaviour, both ...
Brodo, Linda, Curti, Michele, Degano, Pierpaolo, Prandi, Davide, Priami, Corrado, Quaglia, Paola   +5 more
core   +2 more sources

Co‐Assemblies Regulate the Catalytic Activity of Peptide Fibrils

Angewandte Chemie International Edition, Volume 65, Issue 2, 9 January 2026.
Catalytic self‐assembling peptides (cSAPs) form fibrils that catalyze the retro‐aldol reaction of Methodol. Co‐assembly with inactive peptides tunes catalytic efficiency by altering substrate accessibility and the distance to the nucleophilic lysine.
Albin Lahu, Shao‐Lin Wu, Maximilian Schuler, Francesca Mazzotta, Ardit Ramadani, Emirhan Koca, Ingo Lieberwirth, Katharina Landfester, Torsten John, David Y. W. Ng, Tanja Weil   +10 more
wiley   +1 more source

Impact of limited solvent capacity on metabolic rate, enzyme activities, and metabolite concentrations of S. cerevisiae glycolysis [PDF]

, 2008
The cell's cytoplasm is crowded by its various molecular components, resulting in a limited solvent capacity for the allocation of new proteins, thus constraining various cellular processes such as metabolism.
Barabási, AL, De Menezes, MA, Oltvai, ZN, Vazquez, A   +3 more
core   +1 more source

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, Volume 600, Issue 2, Page 239-250, January 2026.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

AMP-activated protein kinase - not just an energy sensor [PDF]

, 2017
Orthologues of AMP-activated protein kinase (AMPK) occur in essentially all eukaryotes as heterotrimeric complexes comprising catalytic α subunits and regulatory β and γ subunits.
A Efeyan, A Kalender, A Woods, B Burwinkel, B Cool, B Xiao, B Xiao, B Xiao, B Zheng, C Fumarola, C Langendorf, C Salatto, C Zhang, C Zhang, C Zhang, D Carling, D Egan, D Gwinn, D Hardie, D Zibrova, E Cokorinos, E Hudson, E Rubenstein, E Toyama, E Yamada, E Yamada, E Zeqiraj, F Groenendijk, F Mayer, F Ross, F Ross, F Ross, G Dogliotti, G Gadaleta-Caldarola, G Gowans, G Polekhina, G Zadra, H O'Neill, H Zong, I Salt, J Oakhill, J Oakhill, J Reihill, J Scott, J Scott, J Scott, K Inoki, K Sakamoto, L Bar-Peled, L Chen, L Chen, L Lantier, L Zhang, M Banko, M Calabrese, M Lu, M Lu, M Lu, M Sanders, M Schmidt, N Aznar, N Stahmann, O Göransson, P Mishra, R Myers, R Willows, R Zoncu, S Eguchi, S Fogarty, S Hawley, S Hawley, U Riek, W Wilson, X Gu, X Li, Y Li, Y Yang, Y Zhang   +77 more
core   +3 more sources

Short‐term actions of epigalocatechin‐3‐gallate in the liver: a mechanistic insight into hypoglycemic and potential toxic effects

FEBS Open Bio, Volume 16, Issue 1, Page 199-221, January 2026.
Epigallocatechin‐3‐gallate (EGCG) acutely inhibited gluconeogenesis and enhanced glycolysis, glycogenolysis, and fatty acid oxidation in perfused rat livers. Mechanistic assays revealed mitochondrial uncoupling, inhibition of pyruvate carboxylation and glucose‐6‐phosphatase, shift of NADH/NAD+ ratios toward oxidation, and loss of membrane integrity ...
Carla Indianara Bonetti, Bruna Lopes Correia, Francielle Cristina Nakamura Manicardi, Nairana Mithieli de Queiroz Eskuarek Melo, Vanesa de Oliveira Pateis, Jurandir Fernando Comar, Anacharis Babeto de Sá‐Nakanishi, Adelar Bracht, Lívia Bracht   +8 more
wiley   +1 more source

RuBisCO depletion improved proteome coverage of cold responsive S-nitrosylated targets in Brassica juncea

Frontiers in Plant Science, 2013
Although in the last few years good number of S-nitrosylated proteins are identified but information on endogenous targets is still limiting. Therefore, an attempt is made to decipher NO signaling in cold treated Brassica juncea seedlings.
Ankita eSehrawat, Jasmeet Kaur Abat, Renu eDeswal   +2 more
doaj   +1 more source

Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK [PDF]

, 2019
Fructose-1,6-bisphosphate (FBP) aldolase links sensing of declining glucose availability to AMPK activation via the lysosomal pathway. However, how aldolase transmits lack of occupancy by FBP to AMPK activation remains unclear.
Changchuan Xie, Chen-Song Zhang, Cixiong Zhang, D. Grahame Hardie, Dong Jiang, Hai-Long Piao, Jianfeng Wu, Jie Chen, Jin-Wei Feng, Jiwen Cui, Li Yu, Meiqin Hu, Mengqi Li, Mengqi Li, Qing-Feng Liu, Sheng-Cai Lin, Shu-Yong Lin, Teng Ma, Wen Wang, Xiao Tian, Xiao-Song Xie, Xiaotong Li, Xin Chen, Yanyan Yang, Yaying Wu, Ying Li, Ying Liu, Yu-Qing Wu, Yue Zong, Zhiyun Ye, Zhizhong Lin, Zhuan Zhou, 宗岳, 张宸崧, 林圣彩   +34 more
core   +5 more sources

Fructose bisphosphate aldolase is involved in the control of RNA polymerase III-directed transcription

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2014
Yeast Fba1 (fructose 1,6-bisphosphate aldolase) is a glycolytic enzyme essential for viability. The overproduction of Fba1 enables overcoming of a severe growth defect caused by a missense mutation rpc128-1007 in a gene encoding the C128 protein, the second largest subunit of the RNA polymerase III complex.
Cieśla, Małgorzata, Mierzejewska, Jolanta, Adamczyk, Małgorzata, Farrants, Ann-Kristin Östlund, Boguta, Magdalena   +4 more
openaire   +2 more sources

NAD⁺ Reduction in Glutamatergic Neurons Induces Lipid Catabolism and Neuroinflammation in the Brain via SARM1

Advanced Science, Volume 13, Issue 6, 30 January 2026.
NAD⁺ homeostasis maintains neuronal integrity through opposing actions of NMNAT2 and SARM1. Loss of NMNAT2 in glutamatergic neurons reprograms cortical metabolism from glucose to lipid catabolism, depletes lipid stores, and triggers inflammation and neurodegeneration.
Zhen‐Xian Niou, Sen Yang, Andrea Enriquez, Nino A. Espinas, Anoosha Sri, Caliel D. Hines, Jason M. Tennessen, Chia‐Shan Wu, Jui‐Yen Huang, Hui‐Chen Lu   +9 more
wiley   +1 more source