Results 131 to 140 of about 395,783 (395)
Generating golden Syrian hamsters with conditional alleles via zygote microinjection of CRISPR/Cas9
Animal Models and Experimental Medicine, EarlyView.We established the first conditional knockout (cKO) model in the golden Syrian hamster by CRISPR/Cas9‐mediated genome editing. Cas9 protein, two sgRNAs, and a donor plasmid carrying loxP‐flanked exon 2 of the ApoF gene were microinjected into one‐cell embryos. The floxed allele was efficiently generated (up to 27%) and transmitted through the germline.
Wei Chen +16 more
wiley +1 more source
High Dietary Fructose: Direct or Indirect Dangerous Factors Disturbing Tissue and Organ Functions
Nutrients, 2017 High dietary fructose is a major contributor to insulin resistance and metabolic syndrome, disturbing tissue and organ functions. Fructose is mainly absorbed into systemic circulation by glucose transporter 2 (GLUT2) and GLUT5, and metabolized in liver ...
Dong-Mei Zhang, Rui-qing Jiao, L. Kong
semanticscholar +1 more source
Animal Models and Experimental Medicine, EarlyView.An 18‐month HFD successfully established a translational Macaca fascicularis model replicating key metabolic disorders (MASH, diabetes, cardiac hypertrophy). MASH was determined by liver biopsy histology, the presence steatosis, inflammatory infiltration, hepatocytic ballooning, and fibrosis were considered as MASH; diabetes was diagnosed according to ...
Hongyi Chen +12 more
wiley +1 more source
Influence of Metabolic Accumulation of Products of Hydrogenomonas Cells on Their Continued Growth Progress Report, 1 May - 31 Oct. 1966 [PDF]
Fructose metabolism by Hydrogenomas eutropha, auxotrophic mutants which produce polysaccharides, and large batch culture ...
Tischer, R. G.
core +1 more source
Elasticity sampling links thermodynamics to metabolic control
, 2013 Metabolic networks can be turned into kinetic models in a predefined steady state by sampling the reaction elasticities in this state. Elasticities for many reversible rate laws can be computed from the reaction Gibbs free energies, which are determined ...
Liebermeister, Wolfram
core +2 more sources
Advances in Nutrition, 2017 Fructose is associated with the biochemical alterations that promote the development of metabolic syndrome (MetS), nonalcoholic fatty liver disease, and type 2 diabetes. Its consumption has increased in parallel with MetS. It is metabolized by the liver,
A. Gugliucci
semanticscholar +1 more source
Establishment of a novel cynomolgus monkey model of hyperuricemia
Animal Models and Experimental Medicine, EarlyView.We established a novel hyperuricemia model in cynomolgus monkeys (A) via oral administration of potassium oxonate, hydrochlorothiazide, and adenine mixed in fruits and vegetables. This model (B) targets uric acid synthesis and enzymatic degradation, and (C) regulates renal and intestinal excretion, thereby stably elevating serum uric acid and serving ...
Ji‐Wei Wang +12 more
wiley +1 more source
Rat brain serotonin synthesis under prolonged consumption of fructose solution
Біологічні студії, 2014 Key metabolites and enzymes of rat brain serotonin biosynthesis pathway under the development of obesity induced by the consumption of 10% fructose solution, have been studied. A reduction of tryptophan by 60±10 % (p < 0.05, n = 10), 5-hydroxytryptophan,
T. P. Karpovets +3 more
doaj +1 more source
The colorimetric determination of hexoses with carbazole [PDF]
, 1947 The optimum conditions for the calorimetric estimation of hexoses by reaction with carbazole in hot sulfuric acid solution have been determined and a convenient procedure, giving results with a precision of 2 to 5 per cent in the range of 50 to 150 γ of ...
Holzman, George +2 more
core
Journal of Biological Chemistry, 2019 Dietary, fructose-containing sugars have been strongly associated with the development of nonalcoholic fatty liver disease (NAFLD). Recent studies suggest that fructose also can be produced via the polyol pathway in the liver, where it may induce hepatic
L. Sánchez-Lozada +8 more
semanticscholar +1 more source