Results 141 to 150 of about 361,236 (411)

The negative and detrimental effects of high fructose on the liver, with special reference to metabolic disorders

Diabetes, Metabolic Syndrome and Obesity, 2019
Brandon H Mai, Liang-Jun YanDepartment of Pharmaceutical Sciences, UNT System College of Pharmacy, University of North Texas Health Science Center, Fort Worth, TX 76107, USAAbstract: The increased consumption of fructose in the average diet through ...
Mai BH, Yan LJ
doaj  

40 years of adding more fructose to high fructose corn syrup than is safe, through the lens of malabsorption and altered gut health–gateways to chronic disease

Nutrition Journal
Labels do not disclose the excess-free-fructose/unpaired-fructose content in foods/beverages. Objective was to estimate excess-free-fructose intake using USDA loss-adjusted-food-availability (LAFA) data (1970–2019) for high fructose corn syrup (HFCS) and
Luanne Robalo DeChristopher
doaj   +1 more source

LRRC4 Deficiency Drives Premature Ovarian Insufficiency by Disrupting Metabolic Homeostasis in Granulosa Cells

Advanced Science, EarlyView.
LRRC4 deficiency disrupts the metabolic homeostasis of mitochondrial aerobic respiration and glycolysis during GC differentiation by inhibiting the ubiquitination‐mediated degradation of YAP, which ultimately leads to POI. These findings reveal the novel molecular etiology of POI and provide a promising target for prevention and treatment.
Yujie Shang, Yunjun Li, Di Han, Kun Deng, Wei Gao, Minghua Wu   +5 more
wiley   +1 more source

Suboptimal light conditions influence source-sink metabolism during flowering [PDF]

, 2016
Reliance on carbohydrates during flower forcing was investigated in one early and one late flowering cultivar of azalea (Rhododendron simsii hybrids).
Ainsworth, Balk, Bieniawska, Bihmidine, Bodson, Bradford, Bustin, Christiaens, Christiaens, Collier, De Keyser, D’Aoust, Hachiya, Horibe, Ishibashi, Ito, Koch, Koch, Kumar, Kumar, Kumar, Kutschera, Lay-Yee, Lemoine, Li, Ma, Mattson, Moscatello, Münch, Paul, Ranwala, Reale, Roitsch, Shahri, Sood, Sun, Tarpley, van Doorn, Winter, Yamada, Yamada, Yap   +41 more
core   +3 more sources

Manipulating the Light Systemic Signal HY5 Greatly Improve Fruit Quality in Tomato

Advanced Science, EarlyView.
This study establishes that HY5, activated by low‐dose light, acts as a systemic signal to enhance tomato fruit quality by directly promoting carotenoid synthesis and sugar metabolism. These findings demonstrate HY5's mobility from leaves to fruits and its application potential through nighttime LED lighting, offering a practical strategy for crop ...
Jiachun Wang, Xiaomeng Li, Jiajia Li, Han Dong, Zhangjian Hu, Xiaojian Xia, Jingquan Yu, Yanhong Zhou   +7 more
wiley   +1 more source

SMC4 Promotes Prostate Cancer Cell Proliferation and Metastasis via the Rheb/mTOR Pathway

Advanced Science, EarlyView.
Structural maintenance of chromosome protein 4 (SMC4) has been implicated in prostate cancer metastasis. Knockdown of SMC4 in RM1‐LM cells significantly attenuates proliferation, migration, and lung metastasis in vivo. Furthermore, SMC4 interacts with GLUT1 (Slc2a1), thereby enhancing glycolysis, ATP production, and activation of the Rheb/mTOR pathway.
Wei Zhang, Siyuan Qin, Xiaokang Li, Ming Chang, Tianzi Wei, Xin Huang, Haibo Tong, Xia Guo, Yi Lu, Jian Zhang   +9 more
wiley   +1 more source

DIFFERENT ACUTE METABOLISM OF FRUCTOSE IN DIALYSIS PATIENTS COMPARED TO HEALTHY SUBJECTS

Kidney Research and Clinical Practice, 2012
The consumption of fructose has increased dramatically during the last two decades and parallels the epidemics of obesity, metabolic syndrome, diabetes and chronic kidney disease ADDIN EN.CITE ADDIN EN.CITE.DATA . Fructose comes naturally e.g.
Björn Anderstam, Ann-Christin Bragfors-Helin, Jonas Axelsson, Abdul Rashid Qureshi, Rolf Wibom, Bengt Lindholm, Peter Stenvinkel   +6 more
doaj   +1 more source

Effects of Dietary Fructose Restriction on Liver Fat, De Novo Lipogenesis, and Insulin Kinetics in Children With Obesity.

Gastroenterology, 2017
BACKGROUND & AIMS Consumption of sugar is associated with obesity, type 2 diabetes mellitus, nonalcoholic fatty liver disease, and cardiovascular disease.
J. Schwarz, S. Noworolski, Ayca Erkin-Cakmak, Natalie J. Korn, M. Wen, V. Tai, G. M. Jones, S. P. Palii, Moises Velasco-Alin, Karen Pan, B. Patterson, A. Gugliucci, R. Lustig, K. Mulligan   +13 more
semanticscholar   +1 more source

Relationship between carbohydrate composition and fungal deterioration of functional strawberry juices preserved using non-thermal treatments [PDF]

, 2018
BACKGROUND: The quantification of the main carbohydrates present in strawberry juices enriched with inulin and fructo-oligosaccharides (FOS) and preserved by non-thermal techniques (vanillin and ultrasound) were studied, as well as the
Cassani, Lucía Victoria, Gomez Zavaglia, Andrea, Moreira, Maria del Rosario, Quintana, Gabriel Sebastian   +3 more
core   +1 more source

Autocrine GDF10 Inhibits Hepatic Stellate Cell Activation via BMPR2/ALK3 Receptor to Prevent Liver Fibrosis

Advanced Science, EarlyView.
Liver fibrosis is a growing global health burden with no specific treatment. HSC activation is the predominant driver of liver fibrogenesis and the current focus in antifibrotic drug discovery. This study identifies autocrine GDF10 activates BMPR2/ALK3‐SMAD1/5/8‐SMAD7 pathway to counteract the TGF‐β‐SMAD2/3 pathway in HSCs, thereby inhibiting HSC ...
Yinliang Zhang, Xiaochen Gai, Yuhui Li, Zuoyu Chen, Xi Zhang, Wei Qiao, Ping Qiu, Chunyuan Du, Sufang Sheng, Jingran Hao, Yujie Zhang, Heng Fan, Xiaorong Li, Ming Liu, Jun Zhang, Zhe Pan, Yongsheng Chang   +16 more
wiley   +1 more source