Results 71 to 80 of about 395,783 (395)

Exclusive Breastfeeding Drives AMPK‐Dependent Thermogenic Memory in BAT and Promotes Long‐Term Metabolic Benefits in Offspring

Advanced Science, EarlyView.
Exclusive breastfeeding establishes a thermogenic memory in brown adipose tissue by activating the HIF1AN/AMPK/α‐ketoglutarate axis via milk‐derived extracellular vesicles enriched in miR‐125a‐5p. This programming preserves metabolic health, while αKG supplementation restores BAT function under mixed feeding, offering strategies to mitigate the ...
Ningxi Wu, Anwen Yin, Xiang Yu, Mingxin Wang, Jiahui Zhang, Kerong Liu, Yutong Hou, Minkai Cao, Yiting Zhang, Xiaoxiao Zhang, Yao Gao, Xirong Guo, Le Zhang, Yun Li   +13 more
wiley   +1 more source

High-Fructose Diet Increases Inflammatory Cytokines and Alters Gut Microbiota Composition in Rats

Mediators of Inflammation, 2020
High-fructose diet induced changes in gut microbiota structure and function, which have been linked to inflammatory response. However, the effect of small or appropriate doses of fructose on gut microbiota and inflammatory cytokines is not fully ...
Yong Wang, W. Qi, Ge Song, Shaojie Pang, Zhenzhen Peng, Yong Li, Panlin Wang   +6 more
semanticscholar   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Suboptimal light conditions influence source-sink metabolism during flowering [PDF]

, 2016
Reliance on carbohydrates during flower forcing was investigated in one early and one late flowering cultivar of azalea (Rhododendron simsii hybrids).
Ainsworth, Balk, Bieniawska, Bihmidine, Bodson, Bradford, Bustin, Christiaens, Christiaens, Collier, De Keyser, D’Aoust, Hachiya, Horibe, Ishibashi, Ito, Koch, Koch, Kumar, Kumar, Kumar, Kutschera, Lay-Yee, Lemoine, Li, Ma, Mattson, Moscatello, Münch, Paul, Ranwala, Reale, Roitsch, Shahri, Sood, Sun, Tarpley, van Doorn, Winter, Yamada, Yamada, Yap   +41 more
core   +3 more sources

Fructose Production and Metabolism in the Kidney.

Journal of the American Society of Nephrology, 2020
Understanding fructose metabolism might provide insights to renal pathophysiology. To support systemic glucose concentration, the proximal tubular cells reabsorb fructose as a substrate for gluconeogenesis.
T. Nakagawa, Richard J. Johnson, Ana Andrés-Hernando, Carlos Roncal-Jimenez, L. Sánchez-Lozada, D. Tolan, M. Lanaspa   +6 more
semanticscholar   +1 more source

FSTL1 Orchestrates Metabolic‐Epigenetic Crosstalk: Glycolysis‐Dependent H3K18 Lactylation Drives Cartilage Fibrosis in Osteoarthritis

Advanced Science, EarlyView.
FSTL1 promotes glycolysis during chondrocyte fibrosis by triggering the HIF‐1 signaling pathway, which causes lactate to accumulate. The buildup of lactate leads to changes in histone lysine lactylation, which in turn enhances the expression of genes associated with fibrosis.
Feng Lu, Yunyuan Yu, Guangrong Yin, Huiqun Hu, Shishuo Li, Yuting Tang, Yimin Liu, Maoyuan Li, Liang liang Wang, Chao Xu, Gongyin Zhao, Baojun Zhou, Yuji Wang   +12 more
wiley   +1 more source

Early Life Exposure to Fructose and Offspring Phenotype: Implications for Long Term Metabolic Homeostasis

Journal of Obesity, 2014
The consumption of artificially sweetened processed foods, particularly high in fructose or high fructose corn syrup, has increased significantly in the past few decades.
Deborah M. Sloboda, Minglan Li, Rachna Patel, Zoe E. Clayton, Cassandra Yap, Mark H. Vickers   +5 more
doaj   +1 more source

D-Tagatose Feeding Reduces the Risk of Sugar-Induced Exacerbation of Myocardial I/R Injury When Compared to Its Isomer Fructose

Frontiers in Molecular Biosciences, 2021
It is known that fructose may contribute to myocardial vulnerability to ischemia/reperfusion (I/R) injury. D-tagatose is a fructose isomer with less caloric value and used as low-calorie sweetener.
Mariaconcetta Durante, Silvia Sgambellone, Laura Lucarini, Paola Failli, Annunziatina Laurino, Debora Collotta, Gustavo Provensi, Emanuela Masini, Massimo Collino   +8 more
doaj   +1 more source

Unveiling the metabolic fate of monosaccharides in cell membranes with glycomic and glycoproteomic analyses. [PDF]

, 2019
Cell membrane protein glycosylation is dependent on the metabolic state of the cell as well as exogenous nutrients available. Although the metabolism and interconversion of monosaccharides have been well-studied, their incorporation into cell surface ...
Cheng, Zhi, Lebrilla, Carlito B, Li, Qiongyu, Park, Dayoung, Wong, Maurice, Xu, Gege   +5 more
core  

Synthesis, Chemistry and Applications of 5-Hydroxymethyl-furfural And Its Derivatives [PDF]

, 2001
The prospect of exciting research activity in the chemistry of furfural derived compounds such as 5-hydroxymethylfurfural (HMF), 2,5-furandicarbaldehyde and 2,5-furan-dicarboxylic acid prompted the writing of this article.
Lewkowski, Jarosław
core   +1 more source