Results 51 to 60 of about 65,143 (262)

Preserved Spermatogenesis and Hormonal Function in Men Receiving a Pretomanid Regimen (BPaMZ) for Pulmonary Drug‐Resistant Tuberculosis

Clinical Pharmacology &Therapeutics, EarlyView.
Pretomanid is a component of the World Health Organization‐recommended treatment regimen for drug‐resistant tuberculosis in patients aged ≥ 14 years. While preclinical rodent studies identified testicular toxicity as a potential clinical liability at elevated doses, no corresponding effects were observed in nonhuman primates nor clinical hormone ...
Pauline Howell, Antonio Lombardi, William Brumskine, Lali Mikiashvili, Kim Boekelheide, Joanna Moreira, Alda Holsta, Matthew Betteridge, Lindsay Thompson, Angela Crook, Paul Bruinenberg, Maria Beumont, Eugene Sun, Francesca Conradie   +13 more
wiley   +1 more source

Reproducibility of Serum Androgen Concentrations by Liquid Chromatography Mass Spectrometry in Healthy Male and Female Athletes

Drug Testing and Analysis, EarlyView.
Box and whiskers plots show the distributions of serum testosterone (T), dihydrotestosterone (DHT), androstenedione (A4), and the ratios of T/FDHT and T/A4. ABSTRACT Detection of androgen doping relies on mass spectrometry‐based methods to detect natural endogenous and exogenous androgens in urine and serum. To distinguish exogenous administration from
D. J. Handelsman, S. Bermon
wiley   +1 more source

Micronutrient Status in Children Suffering From Anorexia Nervosa: A Cohort of 349 Patients in a Referral Center for Eating Disorders

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Anorexia nervosa (AN) is a serious illness in which more than half of all deaths are due to malnutrition. Critically low energy and protein intake are known causes of massive weight loss, whereas micronutrient deficiencies due to a low‐calorie food pattern remain poorly characterized in children with AN. Micronutrient deficiencies in
Zenaida Iordan, Diane Morfin, Marion Bernetiere, Marie Fauchet, Noël Peretti, Bérénice Segrestin, Pierre Poinsot   +6 more
wiley   +1 more source

PERBEDAAN KEKERASAN PERMUKAAN ENAMEL GIGI DESIDUI TERHADAP POLA KONSUMSI IKAN LAUT Studi Pada Anak Usia 5 – 7 Tahun di Desa Teluk Awur dan Desa Jlegong Kabupaten Jepara

ODONTO: Dental Journal, 2018
Background: The descrease of the tooth surface hardness can be affected by the microorganisms activity that ultimately cause the damage of the tooth surface hardness. The process of remineralization is needed to restore the lost minerals.
Astrid Nurlaila Noviasari, Sandy Christiono, Eko Hadianto   +2 more
doaj   +1 more source

Assessing Clinical Severity and Prognosis in Adolescents With Anorexia Nervosa and Atypical Anorexia Nervosa Using the Albumin‐Globulin Ratio

European Eating Disorders Review, EarlyView.
ABSTRACT Objective The albumin‐globulin ratio (AGR) is a biochemical marker reflecting nutritional and inflammatory status, with significant prognostic value in chronic conditions. This study examined its association with clinical/biochemical markers in adolescents with anorexia nervosa (AN) and atypical AN (AAN).
Eylem Şerife Kalkan, Ayşe Bilge Baklaci, Yelda Kiliç, Sinem Akgül, Nilgün Özgül, Melis Pehlivanturk Kizilkan   +5 more
wiley   +1 more source

Transcriptomic signatures reveal systemic adaptations and immune modulation in response to training and competitive racing in horses

Equine Veterinary Journal, EarlyView.
Abstract Background The molecular mechanisms underlying adaptation to physical exertion and racing stress in horses remain incompletely understood. Peripheral blood transcriptomics offers a minimally invasive method to monitor systemic responses to exercise and identify biomarkers of adaptation or overload. Objectives To evaluate transcriptomic changes
Izabela Dąbrowska, Jowita Grzędzicka‐Agko, Paula Kiełbik, Michał Trela, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source

Delphi consensus on Thoroughbred yearling sales endoscopy in Australasia

Equine Veterinary Journal, EarlyView.
Abstract Background Concerns regarding the reliability and consistency of yearling sales endoscopy in Australia and New Zealand have led to reduced industry confidence. Recent studies have clarified the relationship between yearling laryngeal function (YLF) grades and future outcomes.
Josephine L. Hardwick, Benjamin J. Ahern, Brian H. Anderson, Samantha H. Franklin   +3 more
wiley   +1 more source

Protective Effects of Fenugreek and Stevia Extracts on Dexamethasone‐Induced Testicular Damage in a Rat Model

Food Safety and Health, EarlyView.
Fenugreek and stevia extracts protect against dexamethasone‐induced testicular damage in male rats by enhancing antioxidant defenses, improving sperm quality, and restoring hormonal balance, highlighting their potential as natural therapeutics for preventing corticosteroid‐induced reproductive toxicity.
Mosab Gad, Medhat Ibrahim A. Omar, Mohammed I. Elkhateeb, Ahmed A. Zaky   +3 more
wiley   +1 more source

Pharmacogenetics of FSH Action in the Female

Frontiers in Endocrinology, 2019
The purpose of a pharmacogenomic approach is to tailor treatment on the basis of an individual human genotype. This strategy is becoming increasingly common in medicine, and important results have been obtained in oncologic and antimicrobial therapies.
Alessandro Conforti, Alberto Vaiarelli, Danilo Cimadomo, Francesca Bagnulo, Stefania Peluso, Luigi Carbone, Francesca Di Rella, Giuseppe De Placido, Filippo Maria Ubaldi, Ilpo Huhtaniemi, Carlo Alviggi, Carlo Alviggi   +11 more
openaire   +5 more sources

The mitochondrial DNA copy number and ovary‐related reproductive disorders: A bidirectional two‐sample Mendelian randomization study

International Journal of Gynecology &Obstetrics, Volume 169, Issue 1, Page 112-120, April 2025.
Abstract Objective In the present study, a bidirectional two‐sample Mendelian randomization approach was utilized to explore potential causal relationships between mitochondrial DNA copy number (mtDNA‐CN) and ovary‐related reproductive disorders (ORRDs), including ovarian dysfunction, ovarian cyst, polycystic ovary syndrome (PCOS), premature ovarian ...
Ke Peng, Xiao Han, Congquan Wu, Qiaowen Lu, Shujun Gao   +4 more
wiley   +1 more source