Results 91 to 100 of about 12,083 (233)

Revisiting the follicle-stimulation hormone receptor expression and function in human myometrium and adipose tissue

Molecular Medicine
Background Extragonadal follicle-stimulating hormone receptor (FSHR) expression at low levels has been shown in several normal and tumor tissues, including myometrium and adipose tissue. FSH-FSHR signaling in the myometrium has been suggested to regulate
Ewelina Palak, Donata Ponikwicka-Tyszko, Kamila Pulawska-Moon, Maria Sztachelska, Gabriela Milewska, Beata Modzelewska, Tomasz Kleszczewski, Maria L. Koivukoski, Piotr Bernaczyk, Hady Razak Hady, Piotr Gołaszewski, Aleksandra N. Lupinska, Marek Kulikowski, Adam Lemancewicz, Ilpo T. Huhtaniemi, Slawomir Wolczynski, Nafis A. Rahman   +16 more
doaj   +1 more source

Targeted Gene Disruption in Zebrafish Reveals Noncanonical Functions of LH Signaling in Reproduction [PDF]

, 2014
The pivotal role of gonadotropin signaling in regulating gonadal development and functions has attracted much research attention in the past 2 decades. However, the precise physiological role of gonadotropin signaling is still largely unknown in fish. In
Cheng, CHK (reprint author), Chinese Univ Hong Kong, Sch Biomed Sci, Shatin, Hong Kong, Peoples R China., Cheng, Christopher H. K., Chu, Lianhe, Hu, Wei, Li, Jianzhen, Liu, Yun   +5 more
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Brain-derived neurotrophic factor promotes human granulosa-like tumor cell steroidogenesis and proliferation by activating the FSH receptor-mediated signaling pathway

Scientific Reports, 2017
Brain-derived neurotrophic factor (BDNF) and FSH receptor (FSHR) are expressed in ovarian granulosa cells, and play important roles in regulating follicle growth and oocyte maturation.
Min Xie, Meiling Li, Ji Zhou, Xiaomeng Ding, Yidan Shao, Jun Jing, Yuxiu Liu, Bing Yao   +7 more
doaj   +1 more source

The Pathogenic TSH β-Subunit Variant C105Vfs114X Causes a Modified Signaling Profile at TSHR [PDF]

, 2019
1) Background: Central congenital hypothyroidism (CCH) is a rare endocrine disorder that can be caused by mutations in the β-subunit of thyrotropin (TSHB).
Biebermann, Heike, Grüters-Kieslich, Annette, Kalveram, Laura, Kleinau, Gunnar, Rivero-Müller, Adolfo, Scheerer, Patrick, Szymańska, Kamila   +6 more
core   +1 more source

Pharmacogenomic and structural analysis of constitutive G-protein coupled receptor activity [PDF]

, 2007
Premi a l'excel·lència investigadora. Àmbit de les Ciències de la Salut. 2008G-protein coupled receptors (GPCRs) respond to a chemically diverse plethora of signal transduction molecules.
Aldo Jongejan, Alewijnse AE, Ariens EJ, Brown EM, Cesarman E, Chen F, Clark AJ, Clark AJ, Cobbs CS, Furchgott RF, Furchgott RF, Garcia-Borron JC, Henk Timmerman, Henry F. Vischer, Leonardo Pardo, Mannstadt M, Martine J. Smit, Murphy PM, Nauta WT, Rauser L, Reiter EO, Remko A. Bakker, Rob Leurs, Rossier O, Samama P, Scheer A, Stephenson RP, Tabs S, Weiner DM, Wieland K   +29 more
core   +3 more sources

Exploring the expression and potential function of follicle stimulating hormone receptor in extragonadal cells related to abdominal aortic aneurysm

PLoS ONE, 2023
Introduction Follicle stimulating hormone (FSH) is identified to play a role in postmenopausal disease and hypothesized to affect abdominal aortic aneurysm (AAA) onset/progression in postmenopausal women.
V. N. Tedjawirja, A. Mieremet, K. B. Rombouts, C. Yap, A. E. Neele, B. H. Northoff, H. J. Chen, M. Vos, D. Klaver, K. K. Yeung, R. Balm, V. de Waard   +11 more
doaj  

Correlation of follicle-stimulating hormone receptor gene Asn 680 Ser (rs6166) polymorphism with female infertility

Journal of Family Medicine and Primary Care, 2019
Background and Aims: Female infertility is a complex multifactorial, and polygenic disease associated with genetic factors plays an essential role in its formation and follicle development, oocyte maturation, and steroidogenesis regulation in the ovary ...
Sangeeta Rai, Ashish, Preeti Kumari, Anup Singh, Royana Singh   +4 more
doaj   +1 more source

Regulation of gonadotropin receptor gene expression [PDF]

, 1994
The receptors for the gonadotropins differ from the other G protein-coupled receptors by having a large extracellular hormone-binding domain, encoded by nine or ten exons.
Grootegoed, J.A. (Anton), Kraaij, R. (Robert), Themmen, A.P.N. (Axel)   +2 more
core   +1 more source

Chimeras of the Rat and Human FSH Receptors (FSHRs) Identify Residues that Permit or Suppress Transmembrane 6 Mutation-Induced Constitutive Activation of the FSHR via Rearrangements of Hydrophobic Interactions Between Helices 6 and 7 [PDF]

, 2002
Ya‐Xiong Tao, Dario Mizrachi, Deborah L. Segaloff   +2 more
openalex   +1 more source

The G protein-coupled receptor heterodimer network (GPCR-HetNet) and its hub components [PDF]

, 2014
G protein-coupled receptors (GPCRs) oligomerization has emerged as a vital characteristic of receptor structure. Substantial experimental evidence supports the existence of GPCR-GPCR interactions in a coordinated and cooperative manner.
Agnati, Luigi F, Borroto-Escuela, Dasiel O, Brito, Ismel, Di Palma, Michael, Duchou, Jolien, Fuxe, Kjell, Guidolin, Diego, Oflijan, Julia, Rivera, Alicia, Romero-Fernandez, Wilber, Skieterska, Kamila, Suárez-Boomgaard, Diana, Van Craenenbroeck, Kathleen   +12 more
core   +4 more sources