Extragonadal FSHR Expression and Function—Is It Real? [PDF]
Frontiers in Endocrinology, 2019 Expression of the follicle-stimulating hormone receptor (FSHR), besides gonadal tissues, has recently been detected in several extragonadal normal and tumorous tissues, including different types of primary and metastatic cancer and tumor vessel ...
Donata Ponikwicka-Tyszko +2 more
exaly +9 more sources
Atlas of Fshr expression from novel reporter mice
eLife, 2023 The FSH-FSHR pathway has been considered an essential regulator in reproductive development and fertility. But there has been emerging evidence of FSHR expression in extragonadal organs.
Hongqian Chen +10 more
doaj +6 more sources
Differential FSH Glycosylation Modulates FSHR Oligomerization and Subsequent cAMP Signaling [PDF]
Frontiers in Endocrinology, 2021 Follicle-stimulating hormone (FSH) and its target G protein-coupled receptor (FSHR) are essential for reproduction. Recent studies have established that the hypo-glycosylated pituitary FSH glycoform (FSH21/18), is more bioactive in vitro and in vivo than
Uchechukwu T. Agwuegbo +5 more
doaj +7 more sources
Biased Signaling and Allosteric Modulation at the FSHR [PDF]
Frontiers in Endocrinology, 2019 Knowledge on G protein-coupled receptor (GPCRs) structure and mechanism of activation has profoundly evolved over the past years. The way drugs targeting this family of receptors are discovered and used has also changed.
Romain Yvinec +2 more
exaly +7 more sources
Inadequate detection of the FSHR complicates future research on extragonadal FSHR localization
Frontiers in Endocrinology, 2023 IntroductionRecently, follicle stimulating hormone (FSH) through interaction with its receptor (FSHR) has been proposed to play a role in postmenopausal osteoporosis and cardiovascular disease, rather than the loss of estrogen. To explore this hypothesis,
Victoria N. Tedjawirja +5 more
doaj +4 more sources
Combined Effects of the FSHR 2039 A/G and FSHR -29 G/A Polymorphisms on Male Reproductive Parameters
The World Journal of Men's Health, 2021 Purpose: The aim of this study was to evaluate the combined effect of FSHR 2039 A/G and FSHR -29 G/A single nucleotide polymorphisms (SNPs) on the male reproductive function in a cohort of Sicilian men.
Rossella Cannarella +6 more
doaj +4 more sources
Endogenous, tissue-resident stem/progenitor cells in gonads and bone marrow express FSHR and respond to FSH via FSHR-3 [PDF]
Journal of Ovarian Research, 2021 Follicle stimulating hormone (FSH) is secreted by the anterior pituitary and acts on the germ cells indirectly through Granulosa cells in ovaries and Sertoli cells in the testes. Extragonadal action of FSH has been reported but is still debated.
Deepa Bhartiya +4 more
doaj +3 more sources
Polymorphisms in FSHR and GDF9 loci and their associations with litter size in Zel sheep [PDF]
مجله بیوتکنولوژی کشاورزی, 2014 Follicle stimulating hormone receptor (FSHR) and growth differentiation factor 9 (GDF9) both are the most important proteins that affect reproduction process in mammalian.
Nouraldin Moradi +3 more
doaj +2 more sources
Novel FSHR variants causing female resistant ovary syndrome [PDF]
Molecular Genetics & Genomic Medicine, 2020 Background Pathogenic variants of follicle‐stimulating hormone receptor (FSHR) are known to cause amenorrhea and infertility in women. However, only a limited number of pathogenic FSHR variants have been reported, and few reports described detailed ...
Shuzin Khor +3 more
doaj +3 more sources
Targeted destruction of follicle stimulating hormone receptor-positive cancer cells in vitro and in vivo by a lytic peptide Phor21-FSHβ conjugate [PDF]
Molecular MedicineBackground Extragonadal follicle-stimulating hormone (FSH) receptor (FSHR) expression in various cancers and their endothelial vessel cells has highlighted novel opportunities for targeted FSHR therapy.
Nafis A. Rahman +15 more
doaj +2 more sources