Results 11 to 20 of about 3,023 (153)
Extragonadal FSHR Expression and Function—Is It Real? [PDF]
Frontiers in Endocrinology, 2019 Expression of the follicle-stimulating hormone receptor (FSHR), besides gonadal tissues, has recently been detected in several extragonadal normal and tumorous tissues, including different types of primary and metastatic cancer and tumor vessel ...
Nafis A Rahman +2 more
exaly +11 more sources
Endogenous, tissue-resident stem/progenitor cells in gonads and bone marrow express FSHR and respond to FSH via FSHR-3 [PDF]
Journal of Ovarian Research, 2021 Follicle stimulating hormone (FSH) is secreted by the anterior pituitary and acts on the germ cells indirectly through Granulosa cells in ovaries and Sertoli cells in the testes. Extragonadal action of FSH has been reported but is still debated.
Deepa Bhartiya +4 more
doaj +4 more sources
Atlas of Fshr expression from novel reporter mice
eLifeThe FSH-FSHR pathway has been considered an essential regulator in reproductive development and fertility. But there has been emerging evidence of FSHR expression in extragonadal organs.
Hongqian Chen +10 more
doaj +4 more sources
An overview of FSH-FSHR biology and explaining the existing conundrums [PDF]
Journal of Ovarian Research, 2021 FSH was first identified in 1930 and is central to mammalian reproduction. It is indeed intriguing that despite being researched upon for about 90 years, there is still so much more to learn about FSH-FSHR biology.
Deepa Bhartiya, Hiren Patel
doaj +4 more sources
Novel FSHR Variants Causing Female Resistant Ovary Syndrome [PDF]
Molecular Genetics & Genomic Medicine, 2020 Background Pathogenic variants of follicle‐stimulating hormone receptor (FSHR) are known to cause amenorrhea and infertility in women. However, only a limited number of pathogenic FSHR variants have been reported, and few reports described detailed ...
Xuefeng Lu
exaly +4 more sources
Inadequate detection of the FSHR complicates future research on extragonadal FSHR localization
Frontiers in Endocrinology, 2023 IntroductionRecently, follicle stimulating hormone (FSH) through interaction with its receptor (FSHR) has been proposed to play a role in postmenopausal osteoporosis and cardiovascular disease, rather than the loss of estrogen. To explore this hypothesis,
Victoria N. Tedjawirja +5 more
doaj +4 more sources
Differential FSH Glycosylation Modulates FSHR Oligomerization and Subsequent cAMP Signaling [PDF]
Frontiers in Endocrinology, 2021 Follicle-stimulating hormone (FSH) and its target G protein-coupled receptor (FSHR) are essential for reproduction. Recent studies have established that the hypo-glycosylated pituitary FSH glycoform (FSH21/18), is more bioactive in vitro and in vivo than
Uchechukwu T. Agwuegbo +5 more
doaj +2 more sources
FSHR Trans-Activation and Oligomerization [PDF]
Frontiers in Endocrinology, 2018 Follicle stimulating hormone (FSH) plays a key role in human reproduction through, among others, induction of spermatogenesis in men and production of estrogen in women. The function FSH is performed upon binding to its cognate receptor-follicle-stimulating hormone receptor (FSHR) expressed on the surface of target cells (granulosa and Sertoli cells ...
Kamila Szymańska +7 more
openaire +5 more sources
Combined Effects of the FSHR 2039 A/G and FSHR -29 G/A Polymorphisms on Male Reproductive Parameters
The World Journal of Men's Health, 2021 Purpose: The aim of this study was to evaluate the combined effect of FSHR 2039 A/G and FSHR -29 G/A single nucleotide polymorphisms (SNPs) on the male reproductive function in a cohort of Sicilian men.
Rossella Cannarella +6 more
doaj +4 more sources
FSHR antagonists can trigger a PCOS-like state
Systems Biology in Reproductive Medicine, 2021 Over the recent years, FSHR has become an important target for development of fertility regulating agents, as impairment of FSH-FSHR interaction can lead to subfertility or infertility. In our previous study, we identified a 9-mer peptide (FSHβ (89–97)) that exhibited FSHR antagonist activity.
Faiza Hanif, Waghu +6 more
openaire +3 more sources