Results 21 to 30 of about 12,083 (233)

FSHR Trans-Activation and Oligomerization [PDF]

Frontiers in Endocrinology, 2018
Follicle stimulating hormone (FSH) plays a key role in human reproduction through, among others, induction of spermatogenesis in men and production of estrogen in women. The function FSH is performed upon binding to its cognate receptor-follicle-stimulating hormone receptor (FSHR) expressed on the surface of target cells (granulosa and Sertoli cells ...
Adolfo Rivero-Müller, Adolfo Rivero-Müller, Joanna Kałafut, Kamila Szymańska, Alicja Przybyszewska, Michał Kiełbus, Grzegorz Adamczuk, Beata Paziewska   +7 more
openaire   +4 more sources

Lack of accelerated ovarian aging in a follicle-stimulating hormone receptor haploinsufficiency model

Translational Medicine of Aging, 2023
Follicle-stimulation hormone (FSH) and FSH receptor (FSHR) signaling is essential for lifelong ovarian and endocrine functions in females. Previous studies have reported that Fshr haploinsufficiency in female mice led to accelerated ovarian aging ...
Kristen Mehalko, Minhoo Kim, Sanjana Paye, Kelly Koh, Ryan J. Lu, Bérénice A. Benayoun   +5 more
doaj   +1 more source

Polymorphisms in FSHR and GDF9 loci and their associations with litter size in Zel sheep [PDF]

مجله بیوتکنولوژی کشاورزی, 2014
Follicle stimulating hormone receptor (FSHR) and growth differentiation factor 9 (GDF9) both are the most important proteins that affect reproduction process in mammalian.
Nouraldin Moradi, Narges Nazifi, Qodrat Rahimi Miyanaji, Zarbakht Ansari Pir Sarani   +3 more
doaj   +1 more source

CD34 and FSHR Expression to Differentiate Multiple Subtypes of Benign and Malignant Renal Neoplasms

Société Internationale d’Urologie Journal, 2022
BackgroundCurrently, no markers accurately differentiate benign from malignant renal masses. CD34 and FSHR are transmembrane proteins involved in neo-angiogenetic pathways and are differently expressed in several normal and cancerous tissues.
Giancarlo Marra, Didier Meseure, Marine Lefèvre, Andre Nicolas, Laetitia Lesage, Nicolae Ghinea, Marco Moschini, Caio Pasquali, Petr Macek, Claudia Filippini, Paolo Gontero, Rafael Sanchez-Salas, Xavier Cathelineau   +12 more
doaj   +1 more source

Genotyping of cows by LHCGR, FSHR loci and determination of the level of ovulation depending on the expression of the studied genes

Open Veterinary Journal, 2023
Background: Genotyping offers a promising avenue for identifying the healthy reproductive system in cows. The healthy reproductive system in cows is determined by measuring the level of ovulation and by identifying the type polymorphism of specific ...
Yktiyar Sarybayev, Yessengali Ussenbekov, Orynbassar Turebekov, Bekbolat Bekbolat, Ibragim Tutkyshbay   +4 more
doaj   +1 more source

Pilot Study: FSHR Expression in Neuroendocrine Tumors of the Appendix

Journal of Clinical Medicine, 2023
Appendix neuroendocrine neoplasm (ANEN) treatment is based on tumor size and proliferation markers. Recently, the role of the follicle-stimulating hormone receptor (FSHR) from the clinical perspective has also been increasingly discussed. The FSHR is expressed in the endothelial cells of both intratumoral and peritumoral blood vessels, where it ...
Dariusz Starzyński, Sylwia Rzeszotek, Agnieszka Kolasa, Marta Grabowska, Barbara Wiszniewska, Aleksandra Kudrymska, Katarzyna Karpińska, Aleksandra Tołoczko-Grabarek, Agnieszka Janiec, Aleksandra Myszka, Paweł Rynio, Anhelli Syrenicz, Elżbieta Sowińska-Przepiera   +12 more
openaire   +2 more sources

FSHR antagonists can trigger a PCOS-like state

Systems Biology in Reproductive Medicine, 2021
Over the recent years, FSHR has become an important target for development of fertility regulating agents, as impairment of FSH-FSHR interaction can lead to subfertility or infertility. In our previous study, we identified a 9-mer peptide (FSHβ (89–97)) that exhibited FSHR antagonist activity.
Faiza Hanif, Waghu, Karishma, Desai, Sumana, Srinivasan, Kaushiki S, Prabhudesai, Vikas, Dighe, Kareenhalli V, Venkatesh, Susan, Idicula-Thomas   +6 more
openaire   +2 more sources

Reproductive physiology in young men is cumulatively affected by FSH-action modulating genetic variants: FSHR -29G/A and c.2039 A/G, FSHB -211G/T. [PDF]

PLoS ONE, 2014
Follicle-Stimulating Hormone Receptor (FSHR) -29G/A polymorphism (rs1394205) was reported to modulate gene expression and reproductive parameters in women, but data in men is limited.
Marina Grigorova, Margus Punab, Anna Maria Punab, Olev Poolamets, Vladimir Vihljajev, Birutė Zilaitienė, Juris Erenpreiss, Valentinas Matulevičius, Maris Laan   +8 more
doaj   +1 more source

The G-protein coupled estrogen receptor (GPER/GPR30) is a gonadotropin receptor dependent positive prognosticator in ovarian carcinoma patients. [PDF]

PLoS ONE, 2013
Follicle stimulating hormone receptor (FSHR) and luteinizing hormone receptor (LHCGR) were demonstrated to impact upon survival of patients suffering from epithelial ovarian cancer (EOC).
Sabine Heublein, Doris Mayr, Thomas Vrekoussis, Klaus Friese, Simone S Hofmann, Udo Jeschke, Miriam Lenhard   +6 more
doaj   +1 more source

Responsiveness of bovine cumulus-oocyte-complexes (COC) to porcine and recombinant human FSH, and the effect of COC quality on gonadotropin receptor and Cx43 marker gene mRNAs during maturation in vitro [PDF]

, 2003
Substantially less development to the blastocyst stage occurs in vitro than in vivo and this may be due to deficiencies in oocyte competence. Although a large proportion of bovine oocytes undergo spontaneous nuclear maturation, less is known about ...
Calder, Michele D, Caveney, Anita N, Smith, Lawrence C, Watson, Andrew J   +3 more
core   +4 more sources