Polymorphism of ftsI gene in Haemophilus influenzae and emergence of cefotaxime resistance in two Tunisian hospitals [PDF]
New Microbes and New Infections, 2020 The decreased affinity to β-lactams in Haemophilus influenzae is usually caused by specific alterations in penicillin-binding protein 3 due to varieties of substitutions in ftsI gene. This study aimed to characterize the polymorphism of ftsI gene in 19 H.
S. Ferjani +7 more
doaj +4 more sources
Efficacy of Simulated Cefditoren versus Amoxicillin-Clavulanate Free Concentrations in Countering Intrastrain ftsI Gene Diffusion in Haemophilus influenzae [PDF]
Antimicrobial Agents and Chemotherapy, 2011 ABSTRACT This study explores the effects of cefditoren (CDN) versus amoxicillin-clavulanic acid (AMC) on the evolution (within a single strain) of total and recombined populations derived from intrastrain ftsI gene diffusion in β-lactamase-positive (BL + ) and β-lactamase-negative ...
N Gonzalez +2 more
exaly +5 more sources
Antimicrobial resistance characteristics and associated molecular mechanisms of clinically isolated Haemophilus influenzae from the lower respiratory tract in Chongqing, China [PDF]
Frontiers in Cellular and Infection MicrobiologyBackgroundGlobal systematic research on Haemophilus influenzae drug resistance profiles and mechanisms is scarce. Many studies are constrained by single-center designs and restricted sample numbers, hindering the proper monitoring of drug resistance ...
Qiong Huang +12 more
doaj +2 more sources
High diversity of invasive Haemophilus influenzae isolates in France and the emergence of resistance to third generation cephalosporins by alteration of ftsI gene [PDF]
Journal of Infection, 2019 Invasive infections due to Haemophilus influenzae are infrequent following the implementation of vaccination against H. influenzae of serotype b. However, their changing epidemiology may not be clear due to a lack of appropriate genotyping methods combined with antibiotic susceptibility analyses which do not discriminate invasive and non-invasive ...
Ala-Eddine Deghmane +2 more
exaly +4 more sources
Role of inter-species recombination of the ftsI gene in the dissemination of altered penicillin-binding-protein-3-mediated resistance in Haemophilus influenzae and Haemophilus haemolyticus [PDF]
Journal of Antimicrobial Chemotherapy, 2014 To screen the ftsI gene sequences obtained from clinical isolates of non-typeable Haemophilus influenzae (NTHi) and Haemophilus haemolyticus for the presence of mosaic ftsI gene structures, and to evaluate the role of inter-species recombination of the ftsI gene in the formation and distribution of resistant ftsI genes.The ftsI genes of 100 Haemophilus
Elizabeth A Witherden +2 more
exaly +3 more sources
Molecular and Drug Resistance Characteristics of Haemophilus influenzae Carried by Pediatric Patients with Adenoid Hypertrophy [PDF]
MicroorganismsPurpose: The adenoid microbiota plays a key role in adenoid hypertrophy (AH). This study explored the molecular epidemiology and antimicrobial resistance of Haemophilus. Influenzae (H. influenzae) strains in pediatric AH patients.
Nan Xiao +3 more
doaj +2 more sources
Mutant ftsI genes in the emergence of penicillin-binding proteinmediated β-lactam resistance in Haemophilus influenzae in Norway [PDF]
Clinical Microbiology and Infection, 2010 The most important mechanism for beta-lactam resistance in beta-lactamase-negative ampicillin-resistant (BLNAR) isolates of Haemophilus influenzae is the alteration of penicillin-binding protein 3 (PBP3) as a result of ftsI gene mutations. The present study aimed to map PBP3 alterations and to determine the correlation to beta-lactam resistance in ...
Andrew Jenkins, B -E Kristiansen
exaly +3 more sources
Polymorphism in ftsI gene and -lactam susceptibility in Portuguese Haemophilus influenzae strains: clonal dissemination of -lactamase-positive isolates with decreased susceptibility to amoxicillin/clavulanic acid [PDF]
Journal of Antimicrobial Chemotherapy, 2011 The aim of this study was to characterize ampicillin resistance mechanisms in clinical isolates of Haemophilus influenzae from Portugal. Association between specific patterns of amino acid substitutions in penicillin-binding protein 3 (PBP3) (with or without β-lactamase production) and β-lactam susceptibility as well as genetic relatedness among ...
Maria Giufrè +2 more
exaly +3 more sources
Urinary microbiota and bacterial membrane vesicles in chronic kidney disease: contribution to antimicrobial-resistant urinary tract infections [PDF]
Frontiers in Cellular and Infection MicrobiologyChronic kidney disease (CKD) is associated with an increased risk of severe urinary tract infections (UTIs), particularly those caused by antimicrobial-resistant bacteria.
Naoko Shibata +14 more
doaj +2 more sources
Ceftibuten-polymyxin B combination alters resistance and cell wall gene expression in multidrug-resistant Klebsiella pneumoniae. [PDF]
PLoS ONEBackgroundMultidrug-resistant Klebsiella pneumoniae, including carbapenem- and polymyxin-resistant strains, poses a major public health threat by severely limiting therapeutic options.
Mariana Carvalho Sturaro +2 more
doaj +2 more sources