Results 11 to 20 of about 1,840 (163)

Molecular epidemiology of nontypeable Haemophilus influenzae causing community-acquired pneumonia in adults. [PDF]

PLoS ONE, 2013
Nontypeable Haemophilus influenzae (NTHi) is an opportunistic pathogen which causes a variety of respiratory infections. The objectives of the study were to determine its antimicrobial susceptibility, to characterize the β-lactam resistance, and to ...
Carmen Puig, Laura Calatayud, Sara Martí, Fe Tubau, Carolina Garcia-Vidal, Jordi Carratalà, Josefina Liñares, Carmen Ardanuy   +7 more
doaj   +5 more sources

Role of Horizontal Gene Transfer in the Development of Multidrug Resistance in Haemophilus influenzae [PDF]

mSphere, 2020
Haemophilus influenzae colonizes the respiratory tract in humans and causes both invasive and noninvasive infections. Resistance to extended-spectrum cephalosporins in H. influenzae is rare in Europe.
Kristin Hegstad, Haima Mylvaganam, Jessin Janice, Ellen Josefsen, Audun Sivertsen, Dagfinn Skaare   +5 more
doaj   +3 more sources

Influence of TEM-1 β-Lactamase on the Pharmacodynamic Activity of Simulated Total versus Free-Drug Serum Concentrations of Cefditoren (400 Milligrams) versus Amoxicillin-Clavulanic Acid (2,000/125 Milligrams) against Haemophilus influenzae Strains Exhibiting an N526K Mutation in the ftsI Gene [PDF]

Antimicrobial Agents and Chemotherapy, 2007
ABSTRACT The aim of this study was to explore bactericidal activity of total and free serum simulated concentrations after the oral administration of cefditoren (400 mg, twice daily [bid]) versus the oral administration of amoxicillin-clavulanic acid extended release formulation (2,000/125 mg bid) against Haemophilus ...
M, Torrico, L, Aguilar, N, González, M J, Giménez, O, Echeverría, F, Cafini, D, Sevillano, L, Alou, P, Coronel, J, Prieto   +9 more
openaire   +4 more sources

Haemophilus influenzae carriage and antibiotic resistance profile in Belgian infants over a three-year period (2016–2018) [PDF]

Frontiers in Microbiology, 2023
BackgroundNon-typeable Haemophilus influenzae has become increasingly important as a causative agent of invasive diseases following vaccination against H. influenzae type b.
Esra Ekinci, Laura Willen, Juan Pablo Rodriguez Ruiz, Kirsten Maertens, Liesbet Van Heirstraeten, Gabriela Serrano, Magali Wautier, Ariane Deplano, Herman Goossens, Pierre Van Damme, Philippe Beutels, Surbhi Malhotra-Kumar, Delphine Martiny, Heidi Theeten   +13 more
doaj   +3 more sources

ftsI mutations versus beta-lactamase (blaTEM) production in beta-lactam resistance of Haemophilus influenzae: results from an university hospital in Istanbul [PDF]

Journal of Global Antimicrobial Resistance
AIM: To determine in vitro susceptibilities of H. influenzae strains and to reveal the beta-lactam resistance mechanisms involved in those resistant to beta-lactams in our center. METHODS: Antibiotic susceptibilities of 122 H. influenzae isolated in 2022
Meltem Sarı Küçükerol, Burak Aksu, Ufuk Hasdemir   +2 more
doaj   +2 more sources

Mutations in porin LamB contribute to ceftazidime-avibactam resistance in KPC-producing Klebsiella pneumoniae [PDF]

Emerging Microbes and Infections, 2021
Ceftazidime-avibactam (CAZ-AVI) shows promising activity against carbapenem-resistant Klebsiella pneumoniae (CRKP), however, CAZ-AVI resistance have emerged recently. Mutations in KPCs, porins OmpK35 and/or OmpK36, and PBPs are known to contribute to the
Yingyi Guo, Ningjing Liu, Zhiwei Lin, Xiaoliang Ba, Chuyue Zhuo, Feifeng Li, Jiong Wang, Yitan Li, Likang Yao, Baomo Liu, Shunian Xiao, Ying Jiang, Chao Zhuo   +12 more
doaj   +3 more sources

Stepwise evolution and convergent recombination underlie the global dissemination of carbapenemase-producing Escherichia coli [PDF]

Genome Medicine, 2020
Background Carbapenem-resistant Enterobacteriaceae are considered by WHO as “critical” priority pathogens for which novel antibiotics are urgently needed.
Rafael Patiño-Navarrete, Isabelle Rosinski-Chupin, Nicolas Cabanel, Lauraine Gauthier, Julie Takissian, Jean-Yves Madec, Monzer Hamze, Remy A. Bonnin, Thierry Naas, Philippe Glaser   +9 more
doaj   +2 more sources

Diversification of division mechanisms in endospore-forming bacteria revealed by analyses of peptidoglycan synthesis in Clostridioides difficile [PDF]

Nature Communications, 2023
The bacterial enzymes FtsW and FtsI, encoded in the highly conserved dcw gene cluster, are considered to be universally essential for the synthesis of septal peptidoglycan (PG) during cell division.
Shailab Shrestha, Najwa Taib, Simonetta Gribaldo, Aimee Shen   +3 more
doaj   +2 more sources

Identification of Mutations in the mrdA Gene Encoding PBP2 That Reduce Carbapenem and Diazabicyclooctane Susceptibility of Escherichia coli Clinical Isolates with Mutations in ftsI (PBP3) and Which Carry bla_NDM-1

mSphere, 2019
Penicillin-binding proteins (PBPs) are essential for bacterial cell wall biosynthesis, and several are clinically validated antibacterial targets of β-lactam antibiotics.
Srijan Ranjitkar, Folkert Reck, Xiaobo Ke, Qingming Zhu, Glenn McEnroe, Sara L. Lopez, Charles R. Dean   +6 more
doaj   +5 more sources

Evolution of mutations in the ftsI gene leading to amino acid substitutions in PBP3 in Haemophilus influenzae strains under the selective pressure of ampicillin and cefuroxime

International Journal of Medical Microbiology
Background: Aminopenicillins are recommended agents for non-invasive Haemophilus influenzae infections. One of the mechanisms of resistance to β-lactams is the alteration of the transpeptidase region of penicillin binding protein 3 (PBP3) which is caused
Vladislav Jakubu, Iveta Vrbova, Ibrahim Bitar, Marketa Cechova, Lucia Malisova, Helena Zemlickova   +5 more
doaj   +3 more sources