Frontiers in MicrobiologyIntroductionMatrine (MT) is a potential resistance reversal agent. However, it remains unclear whether MT can reverse the resistance of Haemophilus parasuis (H. parasuis) to β-lactams, and, if so, by what mechanism MT works.MethodsWe screened one cefaclor (CEC)-resistant strain (clinical strain C7) from eight clinical (H.
Daojin Yu
exaly +4 more sources
Prevalence of Resistance to β-Lactam Antibiotics and bla Genes Among Commensal Haemophilus parainfluenzae Isolates from Respiratory Microbiota in Poland [PDF]
Microorganisms, 2019 (1) Background: Beta-lactams are the most frequently used antimicrobials, and are the first-line drugs in many infectious diseases, e.g., pneumonia, otitis media. Due to this fact, various bacteria have developed resistance to this group of drugs.
Sylwia Andrzejczuk +4 more
doaj +2 more sources
A Hunt for the Resistance of Haemophilus influnezae to Beta-Lactams [PDF]
AntibioticsInfections due to Haemophilus influnezae require prompt treatment using beta-lactam antibiotics. We used a collection of 81 isolates obtained between 1940 and 2001 from several countries.
Mélanie Denizon +4 more
doaj +2 more sources
Morphological features and signature gene response elicited by inactivation of FtsI in Mycobacterium tuberculosis [PDF]
Journal of Antimicrobial Chemotherapy, 2008 Universally conserved events in cell division provide the opportunity for the development of novel chemotherapeutics against Mycobacterium tuberculosis. The aim of this study was to use the beta-lactam antimicrobials cefalexin and piperacillin to inhibit FtsI and characterize the morphological changes and global transcriptional activities of genes to ...
Richard A, Slayden, John T, Belisle
openaire +2 more sources
Horizontal Gene Transfer of ftsI , Encoding Penicillin-Binding Protein 3, in Haemophilus influenzae [PDF]
Antimicrobial Agents and Chemotherapy, 2007 ABSTRACT Horizontal gene transfer has been identified in only a small number of genes in Haemophilus influenzae , an organism which is naturally competent for transformation. This report provides evidence for the genetic transfer of the ftsI gene, which encodes penicillin-binding ...
Sho, Takahata +6 more
openaire +2 more sources
Journal of Global Antimicrobial Resistance, 2020 Objectives: The aims of this study were to analyse the serotypes of epidemic Haemophilus influenzae and changes in mechanisms of β-lactam resistance over the past decade. Results: Haemophilus influenzae isolates in Western Sichuan from 2013–2014 were non-
Xiao Lei Wang +10 more
doaj +1 more source
A promoter for the first nine genes of the Escherichia coli mra cluster of cell division and cell envelope biosynthesis genes, including ftsI and ftsW [PDF]
Journal of Bacteriology, 1997 We constructed a null allele of the ftsI gene encoding penicillin-binding protein 3 of Escherichia coli. It caused blockage of septation and loss of viability when expression of an extrachromosomal copy of ftsI was repressed, providing a final proof that ftsI is an essential cell division gene.
H, Hara +3 more
openaire +2 more sources
Comparison of the Efficacies of Oral β-Lactams in Selection of Haemophilus influenzae Transformants with Mutated ftsI Genes [PDF]
Antimicrobial Agents and Chemotherapy, 2008 ABSTRACT Horizontal transfer of the mutated ftsI gene from β-lactamase-nonproducing ampicillin-resistant (BLNAR) Haemophilus influenzae to a susceptible strain was examined in vitro under selection with nine oral β-lactams (ampicillin, amoxicillin, cefprozil, cefuroxime, cefpodoxime,
Sho, Takahata +4 more
openaire +2 more sources
Frontiers in Public Health, 2022 BackgroundThe widespread use of antimicrobials and Haemophilus influenzae type b (Hib) vaccine worldwide has altered the epidemiological patterns of invasive H. influenzae.
Yuhong Zhou +5 more
doaj +1 more source
Life, 2021 The surveillance data on antibiotic resistance of Haemophilus influenzae have shown that strains with non-enzymatic resistance to β-lactam antibiotics have been on the rise in the Czech Republic over the last decade.
Vladislav Jakubu +4 more
doaj +1 more source