Results 31 to 40 of about 14,243 (169)

GTP-Bound Escherichia coli FtsZ Filaments Are Composed of Tense Monomers: a Dynamic Nuclear Polarization-Nuclear Magnetic Resonance Study Using Interface Detection

mBio, 2022
FtsZ filaments are the major structural component of the bacterial Z ring and are drivers of bacterial division. Crystal structures for FtsZ from some Gram-positive bacteria in the presence of GTP analogs suggest the possibility of a high-energy, “tense”
Kelsey M. McCoy, Keith J. Fritzsching, Ann E. McDermott   +2 more
doaj   +1 more source

Proposal of Potent Inhibitors for a Bacterial Cell Division Protein FtsZ: Molecular Simulations Based on Molecular Docking and ab Initio Molecular Orbital Calculations

Antibiotics, 2020
The inhibition of a bacterial cell division protein, filamentous temperature-sensitive Z (FtsZ), prevents the reproduction of Mycobacteria. To propose potent inhibitors of FtsZ, the binding properties of FtsZ with various derivatives of Zantrin ZZ3 were ...
Shohei Yamamoto, Ryosuke Saito, Shunya Nakamura, Haruki Sogawa, Pavel Karpov, Sergey Shulga, Yaroslav Blume, Noriyuki Kurita   +7 more
doaj   +1 more source

Structures of a FtsZ single protofilament and a double-helical tube in complex with a monobody

Nature Communications, 2023
FtsZ polymerizes into protofilaments to form the Z-ring that acts as a scaffold for accessory proteins during cell division. Structures of FtsZ have been previously solved, but detailed mechanistic insights are lacking.
Junso Fujita, Hiroshi Amesaka, Takuya Yoshizawa, Kota Hibino, Natsuki Kamimura, Natsuko Kuroda, Takamoto Konishi, Yuki Kato, Mizuho Hara, Tsuyoshi Inoue, Keiichi Namba, Shun-ichi Tanaka, Hiroyoshi Matsumura   +12 more
doaj   +1 more source

A Screening Model of Antibacterial Agents Based on Escherichia coli Cell-Division Protein

Applied Sciences, 2023
Pathogenic Escherichia coli cannot be killed by most antibiotics (including colistin, a last-resort drug) due to the rapid development of antibiotic resistance.
Qiuyu Fan, Jianwen Wu, Bolin Xi, Chunxiao Li, Xiumin Wang, Huanrong Li   +5 more
doaj   +1 more source

The Min System Disassembles FtsZ Foci and Inhibits Polar Peptidoglycan Remodeling in Bacillus subtilis

mBio, 2020
A microfluidic system coupled with fluorescence microscopy is a powerful approach for quantitative analysis of bacterial growth. Here, we measure parameters of growth and dynamic localization of the cell division initiation protein FtsZ in Bacillus ...
Yuanchen Yu, Jinsheng Zhou, Felix Dempwolff, Joshua D. Baker, Daniel B. Kearns, Stephen C. Jacobson   +5 more
doaj   +1 more source

Genetic and biochemical characterization of the MinC-FtsZ interaction in Bacillus subtilis. [PDF]

PLoS ONE, 2013
Cell division in bacteria is regulated by proteins that interact with FtsZ and modulate its ability to polymerize into the Z ring structure. The best studied of these regulators is MinC, an inhibitor of FtsZ polymerization that plays a crucial role in ...
Valdir Blasios, Alexandre W Bisson-Filho, Patricia Castellen, Maria Luiza C Nogueira, Jefferson Bettini, Rodrigo V Portugal, Ana Carolina M Zeri, Frederico J Gueiros-Filho   +7 more
doaj   +1 more source

A Polymerization-Associated Structural Switch in FtsZ That Enables Treadmilling of Model Filaments

mBio, 2017
Bacterial cell division in many organisms involves a constricting cytokinetic ring that is orchestrated by the tubulin-like protein FtsZ. FtsZ forms dynamic filaments close to the membrane at the site of division that have recently been shown to ...
James M. Wagstaff, Matthew Tsim, María A. Oliva, Alba García-Sanchez, Danguole Kureisaite-Ciziene, José Manuel Andreu, Jan Löwe   +6 more
doaj   +1 more source

Non-sporulating ftsZ mutants in Streptomyces coelicolor reveal amino acid residues critical for FtsZ polymerization dynamics

, 2013
During sporulation of Streptomyces coelicolor, the cytokinetic protein FtsZ is assembled into dozens of regularly spaced Z rings, which orchestrate the division of aerial hyphae into spores. We have previously found that a missense allele of ftsZ, ftsZ17(
Flärdh, Klas,, Grantcharova, Nina, Ubhayasekera, Wimal,, Wasserstrom, Sebastian,, Lund University., Ausmees, Nora, Sandblad, Linda   +6 more
core   +2 more sources

Benzimidazole Anthelmintic Compounds Albendazole and Fenbendazole Show Distinct Toxicity on the Nitrogen Fixing Bacterium Mesorhizobium loti and Its Symbiosis With Lotus japonicus

Environmental Toxicology, EarlyView.
ABSTRACT Veterinary medicines, which reach the soil mostly through the application of contaminated manures, can affect beneficial soil microorganisms, such as nitrogen‐fixing rhizobia bacteria, which engage in important symbiotic associations with plants.
Polyxeni Gorgia, Stathis Lagos, Christina N. Nikolaou, Nikoleta Basdeki, Christos Papadopoulos, Dimitrios G. Karpouzas, Daniela Tsikou   +6 more
wiley   +1 more source

Cytological profile of antibacterial FtsZ inhibitors and synthetic peptide MciZ

Frontiers in Microbiology, 2016
Cell division protein FtsZ is the organizer of the cytokinetic ring in almost all bacteria and a target for the discovery of new antibacterial agents that are needed to counter widespread antibiotic resistance.
Lidia Araujo-Bazan, Laura B Ruiz-Avila, David Andreu, Sonia Huecas, Jose M Andreu   +4 more
doaj   +1 more source