Results 21 to 30 of about 6,352 (223)

SLC4A11 mutations in Fuchs endothelial corneal dystrophy [PDF]

Human Molecular Genetics, 2007
The endothelial (posterior) corneal dystrophies, which result from primary endothelial dysfunction, include Fuchs endothelial corneal dystrophy (FECD), posterior polymorphous corneal dystrophy (PPCD) and congenital hereditary endothelial dystrophy (CHED).
Vithana, E.N., Tan, D.T.H., Venkataraman, D., Venkatraman, A., Aung, T., Morgan, P.E., Casey, J.R., Ramprasad, V., Nagasamy, S., Kumaramanickevel, G., Rajagopal, R., Yam, G.H.F., Law, R.W.K., Pang, C.P., Yong, V.H.K   +14 more
openaire   +2 more sources

Role of the TCF4 gene intronic variant in normal variation of corneal endothelium [PDF]

, 2012
PURPOSE: To identify early features of Fuchs endothelial dystrophy (FED) in carriers of the rs613872(G) transcription factor 4 gene (TCF4) aged 20 to 21 years.
Crawford, Geoffrey J., Hewitt, Alex W., MacKey, David A., Mountain, Jenny A., Oates, Sandra K., Pennell, Craig E., Soloshenko, Alla, Warrington, Nicole M., Yazar, Seyhan   +8 more
core   +1 more source

Descemet stripping automated endothelial keratoplasty in Fuchs' corneal endothelial dystrophy: Anterior segment optical coherence tomography and in vivo confocal microscopy analysis [PDF]

, 2015
Background: To evaluate the in vivo corneal changes using in vivo confocal microscopy (IVCM) and anterior segment optical coherence tomography (AS-OCT) in patients with Fuchs' dystrophy who underwent Descemet stripping automated endothelial keratoplasty (
Busin, Massimo, Favuzza, Eleonora, Mencucci, Rita, Tartaro, Ruggero, Virgili, Gianni   +4 more
core   +1 more source

Preclinical Models for Studying Fuchs Endothelial Corneal Dystrophy. [PDF]

Cells
Fuchs Endothelial Corneal Dystrophy (FECD) is a corneal endothelial disease that causes microenvironment alterations and endothelial cell loss, which leads to vision impairment. It has a high global prevalence, especially in elderly populations. FECD is also one of the leading indications of corneal transplantation globally.
Sun F, Xi LWQ, Luu W, Enkhbat M, Neo D, Mehta JS, Peh GSL, Yim EKF.   +7 more
europepmc   +4 more sources

Screening of the COL8A2 gene in an Australian family with early-onset Fuchs’ endothelial corneal dystrophy [PDF]

, 2014
This item is under embargo for a period of 12 months from the date of publication, in accordance with the publisher's ...
Burdon, Kathryn Penelope, Craig, Jamie E, Kuot, Abraham, Mills, Richard Arthur, Sharma, Shiwani   +4 more
core   +1 more source

A large multi-ethnic genome-wide association study identifies novel genetic loci for intraocular pressure. [PDF]

, 2017
Elevated intraocular pressure (IOP) is a major risk factor for glaucoma, a leading cause of blindness. IOP heritability has been estimated to up to 67%, and to date only 11 IOP loci have been reported, accounting for 1.5% of IOP variability.
Banda, Yambazi, Choquet, Hélène, Hoffmann, Thomas J, Jorgenson, Eric, Kvale, Mark N, Melles, Ronald, Nair, K Saidas, Risch, Neil, Schaefer, Catherine, Thai, Khanh K, Yin, Jie   +10 more
core   +3 more sources

Fuchs endothelial corneal dystrophy: The vicious cycle of Fuchs pathogenesis

Progress in Retinal and Eye Research, 2021
Fuchs endothelial corneal dystrophy (FECD) is the most common primary corneal endothelial dystrophy and the leading indication for corneal transplantation worldwide. FECD is characterized by the progressive decline of corneal endothelial cells (CECs) and the formation of extracellular matrix (ECM) excrescences in Descemet's membrane (DM), called guttae,
Stephan Ong Tone, Viridiana Kocaba, Myriam Böhm, Adam Wylegala, Tomas L. White, Ula V. Jurkunas   +5 more
openaire   +3 more sources

Mitochondrial Dysfunction and Mitophagy in Fuchs Endothelial Corneal Dystrophy [PDF]

Cells, 2021
Fuchs endothelial corneal dystrophy (FECD) is a genetically complex, heterogenous, age-related degenerative disease of corneal endothelial cells (CEnCs), occurring in the fifth decade of life with a higher incidence in females. It is characterized by extracellular matrix (ECM) protein deposition called corneal guttae, causing light glare and visual ...
Varun Kumar, Ula V. Jurkunas
openaire   +3 more sources

Mini descemet membrane stripping (m-DMES) in patients with Fuchs' endothelial dystrophy: A new method. [PDF]

, 2017
We present two cases with focal corneal edema due to Fuchs' endothelial dystrophy that were successfully treated with mini Descemet membrane stripping (m-DMES) (diameter of 3-4 mm; at the area of preexisting focal corneal edema) without endothelial ...
Grentzelos, M.A., Kontadakis, G.A., Kymionis, G.D., Liakopoulos, D.A., Naoumidi, I., Petrelli, M.K., Tsoulnaras, K.I.   +6 more
core   +2 more sources

Imaging the Corneal Endothelium in Fuchs Corneal Endothelial Dystrophy [PDF]

Seminars in Ophthalmology, 2019
Fuchs endothelial corneal dystrophy (FECD) is characterized by the progressive degeneration of the corneal endothelium (CE). The purpose of this article is to review the diagnostic tools available to image and assess the CE in FECD. Slit-lamp biomicroscopy with specular reflection and retroillumination are important techniques to assess the CE ...
Stephan Ong Tone, Ula Jurkunas
openaire   +2 more sources