Results 81 to 90 of about 6,352 (223)

Current and Future Cornea Chip Models for Advancing Ophthalmic Research and Therapeutics

Advanced Biology, Volume 9, Issue 7, July 2025.
This review analyzes cornea chip technology as an innovative solution to corneal blindness and tissue scarcity. The examination encompasses recent developments in biomaterial design and fabrication methods replicating corneal architecture, highlighting applications in drug screening and disease modeling while addressing key challenges in mimicking ...
Minju Kim, Kanghoon Choi, Amy Lin, Jungkyu Kim   +3 more
wiley   +1 more source

Rho-associated kinase inhibitor eye drop (Ripasudil) transiently alters the morphology of corneal endothelial cells [PDF]

, 2015
PURPOSE: Ripasudil (Glanatec), a selective Rho-associated coiled coil-containing protein kinase (ROCK) inhibitor, was approved in Japan in September 2014 for the treatment of glaucoma and ocular hypertension.
Fullwood, Nigel J., Inoue, Ryota, Kinoshita, Shigeru, Koizumi, Noriko, Nakano, Shinichiro, Okazaki, Yugo, Okumura, Naoki   +6 more
core   +1 more source

Directional Posterior Corneal Profile Changes in Fuchs' Endothelial Corneal Dystrophy

Investigative Opthalmology & Visual Science, 2015
To determine directional changes in peripheral corneal thickness and corneal astigmatism over a range of severity of Fuchs' endothelial corneal dystrophy (FECD).Eyes with FECD were categorized as mild, moderate, or advanced according to the area and confluence of guttae and the presence of clinical edema.
Wacker, Katrin, McLaren, Jay W., Patel, Sanjay V.   +2 more
openaire   +3 more sources

Cataract Surgery in the Small Adult Eye: A Review

Clinical &Experimental Ophthalmology, Volume 53, Issue 5, Page 558-569, July 2025.
ABSTRACT Modern cataract surgery continues to advance, yet intraocular lens (IOL) based surgery in the small adult eye remains challenging. Thorough preoperative assessment and surgical preparation optimise postoperative outcomes in these cases. Advances in IOL power calculation, including artificial intelligence‐driven formulas, improve accuracy ...
Jonathan E. Moore, Richard N. McNeely, Salissou Moutari   +2 more
wiley   +1 more source

Phacoemulsification and Descemet's membrane endothelial keratoplasty in the presence of a corneal scar.

Vision Pan-America, 2015
To report the surgical outcome and visual rehabilitation  of a patient with Fuchs' dystrophy diagnosed with endothelial dysfunction associated with subepithelial and deep corneal scar and advanced cataract, treated with DMEK combined with ...
Nicolas Cesario Pereira, Aline Moiyama, Isabel Camila Amorim Gonzaga, Adriana dos Santos Forseto   +3 more
doaj   +1 more source

Immunohistochemical Profiling of Corneas With Fuchs Endothelial Corneal Dystrophy [PDF]

Cornea, 2017
Purpose: Fuchs endothelial corneal dystrophy (FECD) is the leading indication for endothelial keratoplasty. Further insight into its pathophysiology is needed to develop alternative therapies. Methods: Sixteen genes from a previous microarray expression experiment (FECD vs.
De Roo, An-Katrien, Janssens, Thomas, Foets, Beatrijs, van den Oord, Joost   +3 more
openaire   +2 more sources

Canine corneal endothelial cell analysis using vital dyes and light microscopy

Veterinary Ophthalmology, Volume 28, Issue 4, Page 675-682, July 2025.
Abstract Purpose To evaluate the use of vital dyes and light microscopy for assessing canine corneal endothelial morphology ex vivo. Methods The corneas of 40 canine eyes (n = 20 dogs) enucleated <24 h following euthanasia or death were isolated and flat‐mounted on a slide. Corneal endothelium was stained via 0.25% trypan blue followed by 0.5% alizarin
Yamit Soueid, Shaden Baransy, Yulia Goncharov, Yael Keinan, Lionel Sebbag   +4 more
wiley   +1 more source

Genome-wide Linkage Scan in Fuchs Endothelial Corneal Dystrophy [PDF]

Investigative Opthalmology & Visual Science, 2009
To perform a genome-wide linkage screen with a single-nucleotide polymorphism (SNP) linkage panel to identify regions of genetic linkage in Fuchs endothelial corneal dystrophy (FECD) and to analyze affected individuals for mutations in the COL8A2 gene.Ninety-two individuals from 22 families with FECD were identified from our multiplex FECD family ...
Natalie A, Afshari, Yi-Ju, Li, Margaret A, Pericak-Vance, Simon, Gregory, Gordon K, Klintworth   +4 more
openaire   +2 more sources

Characterisation of the role played by ELMO1, GPR141 and the intergenic polymorphism rs918980 in Fuchs' dystrophy in the Indian population

FEBS Open Bio, Volume 15, Issue 5, Page 822-835, May 2025.
This study reports the upregulation of ELMO1 and GPR141 in human Fuchs' endothelial corneal dystrophy (FECD) corneal endothelium and ultraviolet A‐induced FECD mice model. A genetic association of an intergenic single nucleotide polymorphism rs918980 present between both genes is observed with FECD in the Indian population.
Susmita Sharma, Samar Kumar Basak, Sujata Das, Debasmita Pankaj Alone   +3 more
wiley   +1 more source

Estudio comparativo entre microscopía confocal y microscopía especular en la valoración del endotelio en córneas con distrofia de Fuchs [PDF]

, 2011
La distròfia endotelial de Fuchs es caracteritza per la formació de guttas endotelials i en estadis avançats pot induir edema corneal i pèrdua d'agudesa visual. A diferència del microscopi especular, el microscopi confocal té un disseny que permet evitar
Charafeddin, Wissam, Universitat Autònoma de Barcelona. Departament de Cirurgia, Universitat Autònoma de Barcelona. Facultat de Medicina   +2 more
core   +1 more source