Results 31 to 40 of about 11,598 (177)

Brown Seaweed Fucoidan Inhibits Cancer Progression by Dual Regulation of mir-29c/ADAM12 and miR-17-5p/PTEN Axes in Human Breast Cancer Cells

, 2017
In this study, we observed that brown seaweed fucoidan inhibited human breast cancer progression by upregulating microRNA (miR)-29c and downregulating miR-17-5p, thereby suppressing their target genes, a disintegrin and metalloproteinase 12 (ADAM12) and ...
Wu, Szu-Yuan;Yan, Ming-De;Wu, Alexander T. H.;Yuan, Kevin Sheng-Po;Liu, Shing Hwa, 劉興華   +1 more
core   +1 more source

Automated synthesis of fucoidan enables molecular investigations in marine glycobiology [PDF]

Fucoidan, a sulfated polysaccharide found in algae, occupies a central yet enigmatic role in marine carbon sequestration and exhibits a wide array of bioactivities.
Silvia , Vidal-Melgosa, Jan-Hendrik, Hehemann, Peter, Seeberger, Conor, Crawford, Mikkel, Schultz-Johansen, Phuong, Luong   +5 more
core   +1 more source

Metals Influence Structure and Solubility of Fucoidan and Strategy of Metal Removal in Fucoidan [PDF]

, 2021
Undaria pinnatifida is a widely distributed species of brown seaweed in New Zealand. Fucoidan is a sulfated polysaccharide which is extracted from U. pinnatifida. Its numerous bioactivities have been studied for several decades.
Luo, Xuegeng
core  

Brown Algae-Derived Fucoidan Exerts Oxidative Stress-Dependent Antiproliferation on Oral Cancer Cells

Antioxidants, 2022
Fucoidan is a dietary brown algae-derived fucose-rich polysaccharide. However, the anticancer effects of fucoidan for oral cancer treatment remain unclear, particularly in terms of its preferential antiproliferation ability and oxidative-stress ...
Jun-Ping Shiau, Ya-Ting Chuang, Kun-Han Yang, Fang-Rong Chang, Jyh-Horng Sheu, Ming-Feng Hou, Jiiang-Huei Jeng, Jen-Yang Tang, Hsueh-Wei Chang   +8 more
doaj   +1 more source

Effect of Hydrolyzed Fucoidan from The Brown Seaweed Sargassum Binderi Sonder Towards Human Breast Cancer T47d Cell Lines

Squalen, 2017
Fucoidan, a sulfated heteropolysaccharide, consists of L-fucose and sulfate ester groups as the main component. Over the past three decades, fucoidan structures and bioactivities have been widely studied. The chemical components (fucose, galactose, small
Ellya Sinurat, Endang Saepudin, Fildzah Alfita Qosthalani   +2 more
doaj   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

The immunomodulating and antioxidant activity of fucoidan on the splenic tissue of rats treated with cyclosporine A

Journal of Basic and Applied Zoology, 2013
Cyclosporine A (CsA), a potent immunosuppressive agent, has several adverse effects on different organs including the spleen. Fucoidan is a sulfated polysaccharide extracted from marine algae and it has numerous biological activities.
Hossam El-Din M. Omar, Heba M. Saad Eldien, Mohammed Saad Badary, Bushra Y. Al-Khatib, Sary Kh. AbdElgaffar   +4 more
doaj   +1 more source

Formulation, Optimization and In Vivo Evaluation of Fucoidan-Based Cream with Anti-Inflammatory Properties

Marine Drugs, 2021
Fucoidan is a polysaccharide found in brown alga with glorious potential for pharmacological activities, among which its anti-inflammatory properties have gained meaningful attention.
Ekaterina D. Obluchinskaya, Olga N. Pozharitskaya, Elena V. Flisyuk, Alexander N. Shikov   +3 more
doaj   +1 more source

Assembled Hyaluronic Acid Therapeutics for Targeting M1 Macrophages and Regulating Immune Homeostasis for Ulcerative Colitis Treatment

Advanced Science, EarlyView.
An orally administered, drug‐free hyaluronic acid nanoassembly, uhNAs‐OA, accumulates in the inflamed colon and is preferentially internalized by M1‐like macrophages via HA‐CD44 interactions. uhNAs‐OA scavenges excess ROS, suppresses NF‐κB signaling and remodels the colonic immune landscape, resulting in robust therapeutic efficacy in acute, chronic ...
Jianqin Wan, Andi Ma, Yiqiong Zhang, Minghao Zhang, Yifeng Lin, Xiaoling Zhang, Hongjun Li, Weidong Han   +7 more
wiley   +1 more source

Fucoidan can function as an adjuvant in vivo to enhance dendritic cell maturation and function and promote antigen-specific T cell immune responses. [PDF]

PLoS ONE, 2014
Fucoidan, a sulfated polysaccharide purified from brown algae, has a variety of immune-modulation effects, including promoting antigen uptake and enhancing anti-viral and anti-tumor effects.
Jun-O Jin, Wei Zhang, Jiang-Yuan Du, Ka-Wing Wong, Tatsuya Oda, Qing Yu   +5 more
doaj   +1 more source