Results 51 to 60 of about 7,614 (186)

Fucoidan-Supplemented Diet Potentiates Immune Checkpoint Blockage by Enhancing Antitumor Immunity

Frontiers in Cell and Developmental Biology, 2021
Immune checkpoint blockade (ICB) therapies such as PD-1 antibodies have produced significant clinical responses in treating a variety of human malignancies, yet only a subset of cancer patients benefit from such therapy.
Juan Yang, Juan Yang, Xianzhi Yang, Wenfeng Pan, Mingshuo Wang, Yuxiong Lu, Yuxiong Lu, Jianeng Zhang, Ziqian Fang, Xiaomin Zhang, Yin Ji, Jin-Xin Bei, Jin-Xin Bei, Jiajun Dong, Yi Wu, Chaoyun Pan, Guangli Yu, Guangli Yu, Penghui Zhou, Bo Li, Bo Li, Bo Li   +21 more
doaj   +1 more source

Current strategies to enhance the target efficiency of advanced multifunctional ultrasound contrast agents in ischemic diseases

Interdisciplinary Medicine, EarlyView.
The graphical abstract outlines a novel multifunctional ultrasound contrast agent for the diagnosis and treatment of ischemic diseases, along with innovative strategies to enhance its targeting efficiency. Abstract Ischemic diseases, such as myocardial infarction, stroke, and peripheral ischemia, are leading causes of death and disability worldwide ...
Yangyang Zhou, Jing Lin, Yu Chen, Jiaqi Zhao   +3 more
wiley   +1 more source

Oral fucoidan improves muscle size and strength in mice

Physiological Reports, 2021
Fucoidan is a sulfated polysaccharide found in a range of brown algae species. Growing evidence supports the long‐term supplementation of fucoidan as an ergogenic aid to improve skeletal muscle performance.
Sally E. McBean, Jarrod E. Church, Brett K. Thompson, Caroline J. Taylor, J. H. Fitton, Damien N. Stringer, Sam S. Karpiniec, Ah Y. Park, Chris van derPoel   +8 more
doaj   +1 more source

Recent Advances in Cryogel Applications for Musculoskeleatal Regeneration

Medicinal Research Reviews, EarlyView.
ABSTRACT Hydrogels have been widely used in tissue engineering due to their high‐water content and biocompatibility, yet their densely cross‐linked microstructure inherently limits cell infiltration, mass transport, and mechanical support. Cryogels, formed through partial freezing and crosslinking under subzero conditions, provide unique 3D macroporous
Dohee Kim, Shinwon Kang, Hyejin Jo, Inseon Kim, Seunghun S. Lee   +4 more
wiley   +1 more source

Active pH Modulation by Proton Channel‐Peptide Nucleic Acid Complex for Effective siRNA Endosomal Escape

Small, EarlyView.
A bioinspired siRNA nanocarrier is engineered by integrating an influenza A M2 proton channel with siRNA through a peptide nucleic acid linker on liposome surfaces. Active proton transport amplifies osmotic stress within endosomes, triggering membrane rupture and cytosolic release.
Seongmin Ga, Nam Hyeong Kim, Si Yeon Ryu, Kyeonghyun Kim, Eun Sung Kang, Hayeon Bae, Seungmin Ryu, Suhyeon Kim, Yeontae Jang, Bok‐Soo Lee, Jiyoung Nam, Minah Suh, Jaecheol Lee, Seung‐gu Kang, Jaekyung Hyun, Huong T. Kratochvil, Yong Ho Kim   +16 more
wiley   +1 more source

Impact of Positively Charged Backbone Modifications on the Properties of Spherical Nucleic Acids

Small, EarlyView.
A synthesis of spherical nucleic acids (SNAs) featuring cationic backbone modifications is presented, together with an analysis of their emerging properties. Introducing positively charged guanidinium groups near the SNA surface enhances cellular uptake and offers a pathway toward more precise control over SNA internalization.
Katherine E. Bujold, Kacper Skakuj, John P. Cavaliere, Caroline D. Kusmierz, Chad A. Mirkin   +4 more
wiley   +1 more source

The Origin, Properties, Structure, Catalytic Mechanism, and Applications of Fucoidan-Degrading Enzymes

Marine Drugs
Fucoidanase is a class of enzymes capable of hydrolyzing fucoidan, a complex sulfated polysaccharide found mainly in marine brown algae and some marine invertebrates.
Yi Zhao, Limin Ning, Penghui Zhu, Jinju Jiang, Zhong Yao, Benwei Zhu   +5 more
doaj   +1 more source

A critical review on extraction, characteristics, physicochemical activities, potential health benefits, and industrial applications of fucoidan

eFood, 2022
Fucoidan is a kind of sulfated polysaccharide that consists mainly of fucose and is found in marine brown alga. Fucoidan is a major bioactive compound in brown seaweeds known to have biological activities including anticancer, anti‐inflammatory ...
Bin Du, Qiancheng Zhao, Caihong Cheng, Huiying Wang, Yanfei Liu, Fengmei Zhu, Yuedong Yang   +6 more
doaj   +1 more source

Dietary modulation of antimicrobial peptides (HAMP and LEAP2) in Chinook salmon (Oncorhynchus tshawytscha) fed a phytobiotic functional diet: Integrated genomic characterisation and tissue‐specific expression

Journal of Fish Biology, EarlyView.
Abstract Antimicrobial peptides (AMPs) are key components of the innate immune system in fish, providing rapid protection against microbial pathogens. Among these, the liver‐expressed antimicrobial peptides (LEAPs), comprising LEAP‐1 (hepcidin; HAMP) and LEAP‐2, play central roles in host defence and iron regulation.
Roberta Marcoli, Jane E. Symonds, Seumas P. Walker, Cesar Lopez, Mark A. Preece, Christopher Battershill, Steve Bird   +6 more
wiley   +1 more source

Effects of Algae β‐Glucan Supplementation on the Performance and Intestinal Immune System of Healthy Weaned Piglets

Journal of Animal Physiology and Animal Nutrition, EarlyView.
ABSTRACT While β‐glucans from plants and yeasts have been extensively studied in weaned piglets, studies examining algae β‐glucans are scarce. Thus, the present study aimed to examine the effects of feeding algae β‐glucan in weaned piglets. Male, 21‐day‐old, weaned crossbred piglets were allotted to three experimental groups, which were fed either an ...
Johanna O. Buckenberger, Felizitas Gutöhrlein, Manfred Henrich, Erika Most, Rose Whelan, John K. Htoo, Robert Ringseis, Klaus Eder   +7 more
wiley   +1 more source