Results 51 to 60 of about 17,367 (263)

Structural Analysis of Fucoidans [PDF]

Natural Product Communications, 2008
Sulfated polysaccharides of brown algae (“fucoidans”) constitute a wide variety of biopolymers from simple sulfated fucans up to complex heteropolysaccharides composed of several neutral monosaccharides, uronic acid and sulfate. The increased interest in this class of polysaccharides is explained by their high and versatile biological activities, and ...
Maria I. Bilan, Anatolii I. Usov
openaire   +1 more source

Antioxidant and anticancer properties of fucoidan isolated from Saccharina Japonica brown algae

Scientific Reports
Fucoidan is a fucose-rich sulfated polysaccharide that has gained attention owing to its various biological activities. In this study, fucoidan was isolated from Saccharina japonica using an enzyme-assisted method, and its antioxidant and anti ...
Qiu-Lin Yue, Yong-Xuan Liu, Fujia Li, Tao Hong, Shou-Sen Guo, Mengrui Cai, Lin Zhao, Le Su, Song Zhang, Chen Zhao, Kun-Lun Li   +10 more
semanticscholar   +1 more source

Effect of Hydrolyzed Fucoidan from The Brown Seaweed Sargassum Binderi Sonder Towards Human Breast Cancer T47d Cell Lines

Squalen, 2017
Fucoidan, a sulfated heteropolysaccharide, consists of L-fucose and sulfate ester groups as the main component. Over the past three decades, fucoidan structures and bioactivities have been widely studied. The chemical components (fucose, galactose, small
Ellya Sinurat, Endang Saepudin, Fildzah Alfita Qosthalani   +2 more
doaj   +1 more source

Fucoidan ameliorates lipid accumulation, oxidative stress, and NF-κB-mediated inflammation by regulating the PI3K/AKT/Nrf2 signaling pathway in a free fatty acid-induced NAFLD spheroid model

Lipids in Health and Disease
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease worldwide. Previous studies have reported that fucoidan can relieve obesity and hepatic steatosis in vivo, although the molecular mechanism remains unclear.
Xue-rong Chu, Xuan Wang, Keqing Feng, Yan-Zhen Bi, Yongning Xin, Shousheng Liu   +5 more
semanticscholar   +1 more source

Automated synthesis of fucoidan enables molecular investigations in marine glycobiology [PDF]

Fucoidan, a sulfated polysaccharide found in algae, occupies a central yet enigmatic role in marine carbon sequestration and exhibits a wide array of bioactivities.
Silvia , Vidal-Melgosa, Jan-Hendrik, Hehemann, Peter, Seeberger, Conor, Crawford, Mikkel, Schultz-Johansen, Phuong, Luong   +5 more
core   +1 more source

Comprehensive synthesis and anticoagulant evaluation of a diverse fucoidan library

Nature Communications
Fucoidan, a sulfated glycan derived from brown algae, has garnered significant attention for its anticoagulant properties. However, the structural complexity and heterogeneity of naturally extracted fucoidan have hindered a comprehensive understanding of
Si-Cong Chen, Xianjin Qin, Nanyu Xiong, Lisha Lin, Yan-Fen Wu, Qin Li, Dongyue Sun, De-Cai Xiong, Cassandra E. Callmann, Ming-Yi Wu, Xin-Shan Ye   +10 more
semanticscholar   +1 more source

Impacts of Oxidative Stress and PI3K/AKT/mTOR on Metabolism and the Future Direction of Investigating Fucoidan-Modulated Metabolism

Antioxidants, 2022
The critical factors for regulating cancer metabolism are oxidative stress and phosphoinositide-3-kinase/AKT serine-threonine kinase/mechanistic target of the rapamycin kinase (PI3K/AKT/mTOR).
J. Shiau, Ya-Ting Chuang, Yuan-Bin Cheng, Jen-Yang Tang, M. Hou, C. Yen, Hsueh-Wei Chang   +6 more
semanticscholar   +1 more source

Disrupting Helicobacter pylori Iron Homeostasis With Bismuth Nanodrug‐Mediated Nutritional Trap for Targeted Gastric Infection Therapy

Advanced Science, EarlyView.
A “nutritional trap” strategy centered on disrupting bacterial iron homeostasis is proposed. The synthesized Bi‐TP@FU (TBF) can target Helicobacter pylori, interfere with the bacterial iron uptake and utilization processes to disrupt its iron homeostasis, induce bacterial death, and meanwhile preserve the balance of the intestinal flora.
Tianye Fang, Jinzhe Tong, Feng Feng, Cong Liu, Chang Shu, Jiaying Zhu, Shibo Zhang, Shuyue Deng, Wanchao Zuo, Yuhan Song, Jun Yang, Yanmin Ju, Yingying Xing, Jianjun Dai   +13 more
wiley   +1 more source

Optimization of fucoidan recovery by ultrasound-assisted enzymatic extraction from South African kelp, Ecklonia maxima

Ultrasonics sonochemistry, 2023
Highlights • Extraction of fucoidan by ultrasound-assisted extraction from Ecklonia maxima.• Optimization of ultrasound-assisted enzymatic extraction through response surface methods and desirability.• Improved extraction kinetics were observed for ...
Z. Mapholi, N. Goosen
semanticscholar   +1 more source

Supramolecular Degraders: An Emerging Paradigm in Targeted Protein Degradation

Advanced Science, EarlyView.
Dynamic supramolecular assembly reshapes targeted protein degradation by coordinating modular degrader construction, delivery, functional integration, and intracellular assembly or activation across proteasomal, endosomal–lysosomal, and autophagy–lysosomal pathways.
Kongjun Liu, Xue Yuan, Yan Zhou, Rui Yuan, Shaocheng Xie, Yong Chen, Peiyi Wang, Jianmei Gao, Qihai Gong   +8 more
wiley   +1 more source