Results 61 to 70 of about 11,598 (177)

Fucoidan reduces secretion and expression of vascular endothelial growth factor in the retinal pigment epithelium and reduces angiogenesis in vitro. [PDF]

PLoS ONE, 2014
Fucoidan is a polysaccharide isolated from brown algae which is of current interest for anti-tumor therapy. In this study, we investigated the effect of fucoidan on the retinal pigment epithelium (RPE), looking at physiology, vascular endothelial growth ...
Michaela Dithmer, Sabine Fuchs, Yang Shi, Harald Schmidt, Elisabeth Richert, Johann Roider, Alexa Klettner   +6 more
doaj   +1 more source

Synergistic Regulation of Biomaterials and Macrophages: A Novel Paradigm in Immunotherapy

MedComm – Biomaterials and Applications, Volume 5, Issue 4, December 2026.
Bioengineered materials mediating the modulation of macrophage plasticity and inflammatory signals in the tumor microenvironment effectively remodel immunoregulatory states, boost antitumor immunity, and promote tissue repair, achieving synergistic therapeutic outcomes.
Jiayu Zhang, Songhang Xing, Shanshan Zhang, Yuan Hao, Xiaojie Qu, Wurihan Bao, Manwei Hao, Han Sun, Mingyuan Dong, Huiling Zhang, Dan Huang, Yiqi Wang, Xuanjie Jiang, Xiaoyu Pu, Yanyan Chi, Xingtong Wang, Xuefeng Li   +16 more
wiley   +1 more source

Effects of Oral Administration of Fucoidan Extracted from Cladosiphon okamuranus on Tumor Growth and Survival Time in a Tumor-Bearing Mouse Model

Marine Drugs, 2012
We evaluated the anti-tumor activities of the oral administration of fucoidan extracted from Cladosiphon okamuranus using a tumor (colon 26)-bearing mouse model.
Yoshiharu Okamoto, Hitoshi Kawamoto, Minoru Morimoto, Hiroyuki Saimoto, Shinsuke Ifuku, Osamu Takashima, Saburo Minami, Tomohiro Osaki, Tomohiro Imagawa, Takeshi Tsuka, Takao Amaha, Toshitsugu Ishihara, Hiroyuki Nakamoto, Kazuo Azuma   +13 more
doaj   +1 more source

Comparative Study of Fucoidan from Saccharina japonica and Its Depolymerized Fragment on Adriamycin-Induced Nephrotic Syndrome in Rats

Marine Drugs, 2020
Nephrotic syndrome (NS) is a clinical syndrome with a variety of causes, mainly characterized by heavy proteinuria, hypoalbuminemia, and edema. At present, identification of effective and less toxic therapeutic interventions for nephrotic syndrome ...
Jiaojiao Tan, Jing Wang, Lihua Geng, Yang Yue, Ning Wu, Quanbin Zhang   +5 more
doaj   +1 more source

Conventional and Emerging Protein Ingredients in Farinaceous Products: Amino Acid Quality, Digestibility, Biological Value, and Functional Performance

Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 6, November 2026.
ABSTRACT The increasing demand for protein‐enriched foods has renewed interest in farinaceous products as widely consumed and technologically adaptable matrices for nutritional improvement. However, protein enrichment cannot be evaluated solely by increases in crude protein content, as nutritional value depends on essential amino acid (EAA) balance ...
P. Álvarez‐Arteaga, M. A. Lazo‐Vélez, L. Mateo Cordero‐Clavijo, S. Paterson   +3 more
wiley   +1 more source

Green Biomaterials: Toward a Multidimensional Classification

Advanced Sustainable Systems, Volume 10, Issue 10, October 2026.
A multidimensional framework is introduced to redefine green biomaterials beyond single descriptors such as bio‐based or biodegradable. By integrating material origin, processing, lifecycle performance, biofunctionality, and application context, the framework resolves inconsistencies in current terminology and provides a foundation for the rational ...
Paulina Wiśniewska, Hossein Ipakchi, Hadi Rastin, Tizazu H. Mekonnen, Mohammad Reza Saeb   +4 more
wiley   +1 more source

Fucoidan is a novel platelet agonist for the C-type lectin-like receptor 2 (CLEC-2)

, 2013
Fucoidan, a sulfated polysaccharide from Fucus vesiculosus, decreases bleeding time and clotting time in hemophilia, possibly through inhibition of tissue factor pathway inhibitor.
Manne, Bhanu Kanth, Watson, Steve P., Getz, Todd M., Naik, Ulhas P., Alshehri, Osama, Dangelmaier, Carol, Hughes, Craig E., Kunapuli, Satya P.   +7 more
core   +1 more source

Disrupting Helicobacter pylori Iron Homeostasis With Bismuth Nanodrug‐Mediated Nutritional Trap for Targeted Gastric Infection Therapy

Advanced Science, Volume 13, Issue 56, 9 October 2026.
A “nutritional trap” strategy centered on disrupting bacterial iron homeostasis is proposed. The synthesized Bi‐TP@FU (TBF) can target Helicobacter pylori, interfere with the bacterial iron uptake and utilization processes to disrupt its iron homeostasis, induce bacterial death, and meanwhile preserve the balance of the intestinal flora.
Tianye Fang, Jinzhe Tong, Feng Feng, Cong Liu, Chang Shu, Jiaying Zhu, Shibo Zhang, Shuyue Deng, Wanchao Zuo, Yuhan Song, Jun Yang, Yanmin Ju, Yingying Xing, Jianjun Dai   +13 more
wiley   +1 more source

Transcriptomically Revealed Oligo-Fucoidan Enhances the Immune System and Protects Hepatocytes via the ASGPR/STAT3/HNF4A Axis

Biomolecules, 2020
Oligo-fucoidan, a sulfated polysaccharide extracted from brown seaweed, exhibits anti-inflammatory and anti-tumor effects. However, the knowledge concerning the detailed mechanism of oligo-fucoidan on liver cells is obscure. In this study, we investigate
Chun-Chia Cheng, Wan-Yu Yang, Ming-Chen Hsiao, Kuan-Hao Lin, Hao-Wei Lee, Chiou-Hwa Yuh   +5 more
doaj   +1 more source

Supramolecular Degraders: An Emerging Paradigm in Targeted Protein Degradation

Advanced Science, Volume 13, Issue 58, 19 October 2026.
Dynamic supramolecular assembly reshapes targeted protein degradation by coordinating modular degrader construction, delivery, functional integration, and intracellular assembly or activation across proteasomal, endosomal–lysosomal, and autophagy–lysosomal pathways.
Kongjun Liu, Xue Yuan, Yan Zhou, Rui Yuan, Shaocheng Xie, Yong Chen, Peiyi Wang, Jianmei Gao, Qihai Gong   +8 more
wiley   +1 more source