Results 41 to 50 of about 11,598 (177)

Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism

Advanced Science, EarlyView.
Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He, Yuwen Wang, Jonathan F. Gong, Yiting Lei, Fei Jin, Weihong Zhu, Rocky S. Tuan, Zhong Alan Li   +7 more
wiley   +1 more source

The Pharmacokinetics of Fucoidan after Topical Application to Rats [PDF]

, 2019
Fucoidan, a fucose-rich polysaccharide from brown algae, has been used for transdermal formulations targeting inflammatory skin conditions, for the treatment of thrombosis, vascular permeability diseases, subcutaneous wounds, and burns.
Vuorela, Heikki, Alexander N. Shikov, Ekaterina D. Obluchinskaya, Pozharitskaya, Olga N., Olga N. Pozharitskaya, Heikki Vuorela, Obluchinskaya, Ekaterina D., Shikov, Alexander N.   +7 more
core   +1 more source

A Postbiotic‐Inducing Ganoderma applanatum Polysaccharide Repairs the Intestinal Barrier via a Phocaeicola vulgatus ‐ Tridecylic Acid Axis

Advanced Science, EarlyView.
This study identifies GAP2, a bioactive polysaccharide fraction derived from Ganoderma applanatum, as a postbiotic inducer that repairs intestinal barrier damage in a gut microbiota‐dependent manner. GAP2 enriches Phocaeicola vulgatus, which degrades GAP2 and promotes tridecylic acid production, triggering Rho/CDC42 signaling and tight‐junction ...
Chuan Zhang, Miaoyu Li, Tiantian Li, Xiaojie Zang, Haiyang Shi, Yaru Liu, Chengcheng Zhang, Jianxin Zhao, Qixiao Zhai, Wei Chen, Fengwei Tian   +10 more
wiley   +1 more source

Fucoidan Structure and Activity in Relation to Anti-Cancer Mechanisms [PDF]

, 2019
Fucoidan is a natural derived compound found in different species of brown algae and in some animals, that has gained attention for its anticancer properties. However, the exact mechanism of action is currently unknown.
Weelden, G. van, Okla, K., Romano, A., Bobinski, M., Weelden, J.W. van, Pijnenborg, J.M.A., Karolina Okła, Pijnenborg, Johanna M. A., Marcin Bobiński, Andrea Romano, Romano, Andrea; id_orcid, Johanna M. A. Pijnenborg, Johanna M. A. Pijnenborg, Okla, Karolina, Bobinski, Marcin, van Weelden, Willem Jan, Geert van Weelden, Willem Jan van Weelden, van Weelden, Geert, Willem Jan Van Weelden   +19 more
core   +2 more sources

Fucoidan present in brown algae induces apoptosis of human colon cancer cells

BMC Gastroenterology, 2010
Background Fucoidan is a sulfated polysaccharide found in brown algae; it has been shown to exhibit a number of biological effects, including anti-tumor effects.
Kim Eun, Park So, Lee Jae-Yong, Park Jung   +3 more
doaj   +1 more source

Precision Nanomedicine for Traumatic Neural Injury: Functional Paradigms and Translational Frameworks

Advanced Science, EarlyView.
This review presents a pathology‐driven framework unifying nanomedicine across TBI, SCI, and PNI. Epidemiological evidence and comparative single‐cell transcriptomic reanalysis define shared pathological modules, injury‐specific effectors, and therapeutic bottlenecks. Six functional paradigms connect nanomaterial structure and biological fate to injury‐
Mouyuan Sun, Shuangyang Li, Zhixu He, Jingyi Xie, Yaxian Luo, Xuankai Fan, Jingyu Zhang, Luying Qin, Lianjie Peng, Tao Qiu, Tian Zhang, Huiming Wang, Mengfei Yu   +12 more
wiley   +1 more source

Oral fucoidan improves muscle size and strength in mice

Physiological Reports, 2021
Fucoidan is a sulfated polysaccharide found in a range of brown algae species. Growing evidence supports the long‐term supplementation of fucoidan as an ergogenic aid to improve skeletal muscle performance.
Sally E. McBean, Jarrod E. Church, Brett K. Thompson, Caroline J. Taylor, J. H. Fitton, Damien N. Stringer, Sam S. Karpiniec, Ah Y. Park, Chris van derPoel   +8 more
doaj   +1 more source

Silk Fibroin for Cardiovascular Medical Devices: Review of Material Properties, Applications, and Clinical Potential

Advanced NanoBiomed Research, EarlyView.
Silk fibroin is an attractive natural biomaterial that can be engineered into diverse cardiovascular constructs, including vascular grafts, cardiac patches, heart valves, and stent coatings. Its tunable biological and mechanical properties have driven substantial preclinical progress; however, widespread clinical translation in cardiovascular ...
Mahsa Haghighattalab, Matt Govendir, Kristina Andelovic, Zachary Och, Fatemeh Karimi, Munira Xaymardan, Tomasz Jungst, Jelena Rnjak‐Kovacina, Nona Farbehi   +8 more
wiley   +1 more source

Influence of Direct Saponification Conditions on Sterol Yield and Composition of the Unsaponifiable Fraction of the Microalga Isochrysis galbana and the Seaweed Ascophyllum nodosum

Journal of the American Oil Chemists' Society, EarlyView.
ABSTRACT Saponification is a key step for recovering the unsaponifiable fraction (USF) of lipids, which contains bioactive sterols, tocopherols, and carotenoids. This study optimized direct saponification conditions (50–300 g L−1 KOH; 60°C–100°C) to recover sterol‐rich USFs from the microalga Isochrysis galbana and the brown seaweed Ascophyllum nodosum,
Mina Zareie, Suzanne M. Budge
wiley   +1 more source

Fucoidan-Mimetic Glycopolymers : Synthesis and Biomedical Applications

, 2016
The marine polysaccharide fucoidan has demonstrated several interesting biological properties, for instance being antiviral, anticoagulant, anti-inflammatory, anticancer, and platelet activating.
Tengdelius, Mattias, Konradsson, Peter,, Griffith, May,, Tengdelius, Mattias,, Påhlsson, Peter,, Johansson, Mats,   +5 more
core   +1 more source