Results 91 to 100 of about 15,330 (252)

Posttranslational modifications of heterologous proteins expressed in Nicotiana benthamiana

Plant Biotechnology Journal, Volume 24, Issue 1, Page 44-54, January 2026.
Summary The success of Nicotiana benthamiana as a workhorse for heterologous protein production is closely linked to its accessibility and tolerance to genetic manipulation, allowing efficient engineering of posttranslational protein modifications (PTMs) that are critical for the function and stability of heterologous proteins.
Kathrin Göritzer, Somanath Kallolimath, Richard Strasser   +2 more
wiley   +1 more source

A fucosyltransferase inhibition assay using image-analysis and digital microfluidics.

Biomicrofluidics, 2019
Sialyl-LewisX and LewisX are cell-surface glycans that influence cell-cell adhesion behaviors. These glycans are assembled by α(1,3)-fucosyltransferase enzymes.
L. Leclerc, Guy Soffer, D. Kwan, Steve C. C. Shih   +3 more
semanticscholar   +1 more source

Heterologous Production of Cyprosin B in Nicotiana benthamiana: Unveiling the Role of the Plant‐Specific Insert Domain in Protein Function and Subcellular Localisation

Plant Biotechnology Journal, Volume 24, Issue 1, Page 256-272, January 2026.
ABSTRACT Plant systems have gained increased attention as an alternative platform for producing heterologous proteins, particularly for industrially relevant proteins. The Cynara cardunculus L. flower extract is traditionally used in cheese production across Mediterranean countries due to its milk‐clotting properties.
Saraladevi Muthusamy, Ramesh Raju Vetukuri, Anneli Lundgren, Sungyong Kim, Pruthvi B. Kalyandurg, Åke Strid, Li‐Hua Zhu, Selvaraju Kanagarajan, Peter E. Brodelius   +8 more
wiley   +1 more source

Prognostically Significant Glycan Profiles of Clear Cell Renal Cell Carcinoma Identified by Integrated Glycome–Methylome Analysis

Pathology International, Volume 76, Issue 1, January 2026.
Comprehensive glycomics analysis and genome‐wide DNA methylation analysis using tissue samples of clear cell renal cell carcinoma (ccRCC) have revealed that the glycan profile, including “immature” N‐type glycans, may be attributable to epigenetic regulation of glycogenes.
Yoshiko Kitazume, Eri Arai, Mao Fujimoto, Kentaro Ohara, Atsushi Matsuda, Shuichi Kakuda, Hiroyuki Fujimoto, Akiko Miyagi Maeshima, Nobuyoshi Hiraoka, Teruhiko Yoshida, Atsushi Kuno, Yae Kanai   +11 more
wiley   +1 more source

Fucosyltransferase VII promotes proliferation via the EGFR/AKT/mTOR pathway in A549 cells

OncoTargets and Therapy, 2017
Fucosyltransferase VII (FUT7) is one of a1,3-fucosyltransferases family that catalyzes the final fucosylation step in the synthesis of Lewis antigens and generates a unique glycosylated product sialyl Lewis X (sLeX). sLeX can serve as ligands for E- or P-
Jinxiao Liang, Wei Gao, L. Cai
semanticscholar   +1 more source

Intestinal Barrier Glycosylation for Gut Physiology and Pathology

Barrier Immunity, Volume 1, Issue 1, Page 20-26, December 2025.
ABSTRACT The intestinal barrier is a selective structure that safeguards the body from external threats while permitting nutrient absorption and immune surveillance. It consists of the outer mucus layer, the intermediate layer of intestinal epithelial cells (IECs), and the inner layer of immune cells. The proteins in the mucus layer and within IECs are
Girak Kim, Deji Ye, Yikun Yao, Chuan Wu
wiley   +1 more source

Clinical significance and biological function of fucosyltransferase 2 in lung adenocarcinoma

OncoTarget, 2017
Fucosylation, which is catalyzed by fucosyltransferases (FUTs), is one of the most important glycosylation events involved in cancer. Studies have shown that fucosyltransferase 8 (FUT8) is overexpressed in NSCLC and promotes lung cancer progression ...
Wenyuan Zhou, Huijun Ma, Guoqing Deng, Lili Tang, Jianxin Lu, Xiaoming Chen   +5 more
semanticscholar   +1 more source

Multi‐omic data integration and exploiting metabolic models using systems biology approach increase precision in subtyping and early diagnosis of cancer

Quantitative Biology, Volume 13, Issue 4, December 2025.
Abstract Cancer is a complex and heterogeneous disease characterized by various genetic and epigenetic alterations. Early diagnosis, accurate subtyping, and staging are essential for effective, personalized treatment and improved survival rates. Traditional diagnostic methods, such as biopsies, are invasive and carry operational risks that hinder ...
Ezgi Tanıl, Emrah Nikerel
wiley   +1 more source

First Step Towards the Humanisation of Protein N‐Glycosylation in Chlamydomonas reinhardtii Through Heterologous Expression of α(1,2)‐Mannosidases

Plant Biotechnology Journal, EarlyView.
C. Plasson, J. Balieu, P. Lerouge, M. Bardor, E. Mathieu‐Rivet   +4 more
wiley   +1 more source

Genetic mapping of a chickpea (Cicer arietinum L.) diversity panel for mineral biofortification towards human nutrition

The Plant Genome, Volume 18, Issue 4, December 2025.
Abstract Chickpea (Cicer arietinum L.) is a cool‐season legume with low fats and high concentrations of protein, carbohydrates, and minerals. As such, chickpea can contribute to alleviate hidden hunger due to mineral deficiencies and malnutrition, particularly in Asian and African countries.
Sonia Salaria, Lucas Boatwright, George Vandemark, Dil Thavarajah   +3 more
wiley   +1 more source