Results 71 to 80 of about 12,774 (221)

Pathophysiology of the gut–eye axis in a Sjögren's disease‐like dry eye mouse model: An exploratory evaluation of dietary heat‐treated Enterococcus faecalis FK‐23

Experimental Physiology, Volume 111, Issue 10, Page 4507-4524, 1 October 2026.
Abstract Sjögren's disease is an autoimmune disease characterized by severe dry eye, but its pathophysiology remains unclear. Non‐obese diabetic (NOD) mice develop Sjögren's disease‐like dry eye prior to the onset of diabetes. Although intestinal immune abnormalities precede diabetes in NOD mice, their relationship to dry eye remains poorly understood.
Kenji Goto, Shigekazu Takemura, Yukiko Minamiyama, Toshikazu Yoshikawa   +3 more
wiley   +1 more source

Plasmid Display for Stabilization of Enzymes Inside the Cell to Improve Whole-Cell Biotransformation Efficiency

Frontiers in Bioengineering and Biotechnology, 2020
Recombinant whole-cell biocatalysts are widely used for biotransformation of valuable products. However, some key enzymes involved in biotransformation processes are unstable and cannot be easily expressed in the functional form.
Yunjeong Park, Jonghyeok Shin, Jinkyeong Yang, Hooyeon Kim, Younghun Jung, Hyunseok Oh, Yongjoon Kim, Jaehyeon Hwang, Myeongseo Park, Choongjin Ban, Choongjin Ban, Ki Jun Jeong, Sun-Ki Kim, Dae-Hyuk Kweon, Dae-Hyuk Kweon, Dae-Hyuk Kweon   +15 more
doaj   +1 more source

Rapidly self-renewing human multipotent marrow stromal cells (hMSC) express sialyl Lewis X and actively adhere to arterial endothelium in a chick embryo model system. [PDF]

PLoS ONE, 2014
There have been conflicting observations regarding the receptors utilized by human multipotent mesenchymal bone marrow stromal cells (hMSC) to adhere to endothelial cells (EC).
Harris E McFerrin, Scott D Olson, Miriam V Gutschow, Julie A Semon, Deborah E Sullivan, Darwin J Prockop   +5 more
doaj   +1 more source

3D Bioprinted Glioblastoma Multiforme Models: How the Extracellular Matrix Glycosignature Influences Drug Response

Advanced Functional Materials, Volume 36, Issue 78, 28 September 2026.
Aberrant glycosylation in the glioblastoma tumor microenvironment drives therapeutic resistance. Here, a 3D bioprinted model was engineered by incorporating α‐NeuNAc‐(2→3)‐β‐D‐Gal‐ and chondroitin sulfate. Combined multiplex immunofluorescence and synchrotron‐based nanoCT analysis revealed that glycan‐matrix interactions dictate specific drug‐escape ...
Francesca Cadamuro, Marco Piazzoni, Ilaria Borghi, Alberto Baeri, Alessandro Fumagalli, Federica Perillo, Hafiz Muhammad Fahad, Martina Ghizzi, Luca Crippa, Gabriella Nicolini, Angela Bentivegna, Daniele Ramazzotti, Valentina Zuliani, Mirko Rivara, Carlo Giorgio Giussani, Andrea Di Cristofori, Guido Cavaletti, Federica Facciotti, Sobhan Sheikhi, Claire Seydoux, Murielle Salome, Peter Cloetens, Alberto Bravin, Paola Coan, Francesco Nicotra, Laura Russo   +25 more
wiley   +1 more source

In vivo activity of recombinant human Lewis fucosyltransferase III in leaves of Nicotiana tabacum

, 2008
International audienceFucosylation in plants occurs in glycoproteins and polysaccharides but the function of fucosylation is largely unknown. We aimed to analyze the effects of over-expression of human fucosyltransferase III (hFucT III) on in vivo N ...
Labrousse, Pascal, Léonard, R., Costa, Guy, P. Labrousse, Lhernould, Sabine, S. Lhernould, D. Lejolly, Lejolly, D., M. Carlué, R. Léonard, G. Costa, Carlué, M.   +11 more
core   +1 more source

O-Glycosylation of thrombospondin type 1 repeats : identification and characterisation of β1,3-glucosyltransferase [PDF]

, 2008
Rare types of protein glycosylation often occur in a domain-specific manner required for important biological functions (Okajima et al. 2008). O-linked fucosylation, where the fucose is linked directly to the hydroxyl groups of serine or threonine ...
Keusch, Krisztina
core   +1 more source

Intestinal epithelium-specific Fut2 deficiency promotes colorectal cancer through down-regulating fucosylation of MCAM

Journal of Translational Medicine, 2023
Background Our previous study showed that fucosyltransferase 2 (Fut2) deficiency is closely related to colitis. Colitis increases the risk for the development of colorectal cancer (CRC). This study aimed to investigate the effect and underlying mechanism
Weijun Wang, Xuelian Tang, Caihan Duan, Shuxin Tian, Chaoqun Han, Wei Qian, Xin Jiang, Xiaohua Hou, Rong Lin   +8 more
doaj   +1 more source

Transcriptional Regulation of Fucosyltransferase 1 Gene Expression in Colon Cancer Cells

The Scientific World Journal, 2013
The α1,2-fucosyltransferase I (FUT1) enzyme is important for the biosynthesis of H antigens, Lewis B, and Lewis Y. In this study, we clarified the transcriptional regulation of FUT1 in the DLD-1 colon cancer cell line, which has high expression of Lewis ...
Fumiko Taniuchi, Koji Higai, Tomomi Tanaka, Yutaro Azuma, Kojiro Matsumoto   +4 more
doaj   +1 more source

CircFut8 Suppresses Bladder Cancer by Modulating SRSF9‐Dependent Pre‐mRNA Splicing

The Journal of Gene Medicine, Volume 28, Issue 9, September 2026.
This schematic illustrates the mechanism by which circFut8 suppresses bladder cancer progression. Under high circFut8 levels, circFut8 competitively binds the splicing factor SRSF9, reducing SRSF9's association with FUT8 pre‐mRNA. This promotes exon 3 skipping, leading to increased production of the FUT8‐4 splice variant, which correlates with reduced ...
Weifeng Yang, Lv Yao, Lijun Wan, Changshui Zhuang   +3 more
wiley   +1 more source

Trafficking and localization studies of recombinant alpha1, 3- fucosyltransferase VI stably expressed in CHO cells [PDF]

, 1998
Peripheral α1,3-fucosylation of glycans occurs by the action of either one of five different α1,3-fucosyltransferases (Fuc-Ts) cloned to date. Fuc-TVI is one of the α1,3-fucosyltransferases which is capable to synthesize selectin ligands.
Borsig, L, Berger EG, Katopodis AG, Borsig L, Bowen BR   +4 more
core   +1 more source