Results 111 to 120 of about 875,334 (280)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Prism-free fabrication of multiplexed holographic waveguide couplers for full-color near-eye displays

Journal of Information Display
Full-color holographic waveguide couplers are required in advanced augmented reality (AR) near-eye display (NED) technologies due to their superior light manipulation capabilities.
Rajveer Kaur, Raj Kumar
doaj   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

White Light-Emitting Flexible Displays with Quantum-Dot Film and Greenish-Blue Organic Light-Emitting Diodes

Micromachines
White organic light-emitting diodes (OLEDs) represent a significant technology in the display industry for the achievement of full color. However, sophisticated technologies are required for white light emission.
Young Woo Kim, Seojin Kim, Chaeyeong Lee, Joo Hyun Jeong, Yun Hyeok Jeong, Yuhwa Bak, Seo Hyeon Kim, Sung Jin Park, Ko Eun Ham, Doeun Lee, Junpyo Song, Youngjin Song, Seung-Chan Jung, Oh Kwan Kwon, Jae-Hee Han, Sang Jik Kwon, Eou-Sik Cho, Yongmin Jeon   +17 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Polychromatic display of thermochromic liquid crystals enabled by near-infrared laser scanning

AIP Advances
This paper presents a polychromatic display (PD) utilizing thermochromic liquid crystals (TLCs) that exhibit temperature-dependent color changes operated via near-infrared (NIR) laser scanning.
Jonguk Yang, Sanghyun Ju
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Conversion of 2D picture to color 3D holography using end-to-end convolutional neural network

PhotoniX
In the field of holographic 3D display, generating a three-dimensional (3D) computer-generated hologram (CGH) from a single two-dimensional (2D) image has been a significant challenge due to the high-dimensionality of the problem.
Chenliang Chang, Chenzhou Zhao, Bo Dai, Qi Wang, Jun Xia, Songlin Zhuang, Dawei Zhang   +6 more
doaj   +1 more source

Red quantum-dot common layer for organic-quantum-dot hybrid light-emitting diodes for full-color displays

Journal of Information Display
Organic and quantum dot (QD) light-emitting diodes (OLEDs and QLEDs, respectively) have been known for their practical application in full-color displays. Each primary color-emitting layer (EML) needs to be patterned via fine metal shadow masks (FMMs) or
Suhyeon Lee, Hansol Seo, Doyoon Shin, Wan Ki Bae, Jeonghun Kwak   +4 more
doaj   +1 more source