Results 101 to 110 of about 4,551,617 (315)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Modal Analysis of Marine Pipeline Based on Full-scale Fatigue Test System

open access: yesShiyou jixie, 2018
In the past, the full-scale fatigue tests of marine pipelines were mostly focused on the bending fatigue. Considering the uneven circumferential force on the pipeline weld and the prolonged test period, the resonance principle is proposed for the fatigue
Liang Ke   +4 more
doaj  

Laboratory testing of full scale lifeboat: pendulum tests

open access: yes, 2010
A set of experiments were designed and conducted using a modified 20-person TEMPSC. The experiments involved suspending ice spheres from a line acting as a pendulum. Thesphere was then set at a specified angle, and allowed to freefall in the pendulum’s naturalarc until impact with the panel.
openaire   +2 more sources

Experimental investigation of an ejector-powered free-jet facility [PDF]

open access: yes
NASA Lewis Research Center's (LeRC) newly developed Nozzle Acoustic Test Rig (NATR) is a large free-jet test facility powered by an ejector system.
Long, Mary JO
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Testing of aircraft passenger seat cushion materials. Full scale, test description and results, volume 1 [PDF]

open access: yes
Eight different seat cushion configurations were subjected to full-scale burn tests. Each cushion configuration was tested twice for a total of sixteen tests. Two different fire sources were used. They consisted of one liter of Jet A fuel for eight tests
Duskin, F. E.   +2 more
core   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

Fatigue load optimization and test verification of the full-scale aileron

open access: yesJixie qiangdu
In the fatigue test of aircraft wing structural components, the fatigue design loads need to be optimized so as to reduce the bending, shear and torsion load errors applied during the test.
LIU Lu   +4 more
doaj  

High-Temperature Fatigue Testing of Turbine Blades

open access: yesFatigue of Aircraft Structures
This paper evaluates the efficacy of a patented grip for high-temperature fatigue testing by establishing the S-N curve for full-scale nickel-based turbine blades under simulated environmental conditions.
Kopec Mateusz   +3 more
doaj   +1 more source

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