Results 111 to 120 of about 8,764 (251)

B Cells are Activated via a Nanoporous Interface that Stabilizes Microvilli and Engages Mechanosensitive Ion Channels

Advanced Science, EarlyView.
B cells can be activated independently of antigen recognition via mechanical stimulation through nanoporous substrates. Exposure to such substrates induced B cell microvilli extension into the pores, intracellular Ca2+ signaling, phosphorylation of signaling proteins, and CD69 expression.
Nozie D. Aghaizu, Willi Weber, Nadine Strempel, Asya Polat, Enrico Klotzsch   +4 more
wiley   +1 more source

GENETIC VARIATION IN A WIDE GENE BASE POPULATION OF SWEET POTATO [Ipomoea batatas (L) Lam]

Annals of Tropical Research, 1988
Design I mating system was used to estimate the components of genetic variation of sweet potato base population. Characters studied were total root yield, weight and number of marketable roots, total number of roots, fresh weight of vines, harvest index,
Algerico M. Mariscal, Azucena L. Carpena
doaj  

Biofortification of Sweetpotato (Ipomoea batatas [L.] Lam.) in Cuba

Agriculture
A breeding program was established in Cuba using 19 full-sib families of sweetpotato (Ipomoea batatas [L.] Lam.) introduced as botanical seed from the International Potato Center (CIP).
Alfredo Morales, Iván Javier Pastrana Vargas, Dania Rodríguez, Federico Diaz, Peiyong Ma, Zhaodong Jia, Xiaofeng Bian, José Efraín González, Vaniert Ventura, Yoel Beovides, Adrian Rubio, Alay Jiménez, Orelvis Portal, Amparo Rosero   +13 more
doaj   +1 more source

Loss of SHP1 in Spinal Astrocytes Triggers T‐Lymphocyte Infiltration and Nociceptive Hypersensitivity

Advanced Science, EarlyView.
Astrocyte‐specific SHP1 deletion disrupts astrocyte–vascular interactions and compromises BBB integrity while enhancing STAT1‐dependent CXCL10 expression. These changes synergistically promote peripheral CD4+ and CD8+ T‐cell infiltration into the SDH. The infiltrating T cells secrete IFN‐γ, which in turn activates microglia.
Lan‐Xing Yi, Lin Yang, Kang‐Li Wang, Hui‐Zhu Liu, Rui‐Ying Chen, Min Su, Xiao Xiao, Yu‐Qiu Zhang   +7 more
wiley   +1 more source

Transcription Factor HOXC11 Drives Colorectal Cancer Progression and Metastasis via CAMK2A‐Dependent CXCL5 Upregulation

Advanced Science, EarlyView.
HOXC11 drives colorectal cancer progression by transcriptionally activating CAMK2A, which triggers NF‐κB–dependent CXCL5 upregulation. CXCL5–CXCR2 signaling further reinforces HOXC11 expression through the ERK1/2–SP1 axis, forming a prometastatic positive feedback loop that is effectively disrupted by combined CAMK2A and CXCR2 inhibition.
Qingyang Sun, Hengjie Xu, Sheng Yang, Jiahui Zhou, Chuanxin Tian, Hongxu Nie, Chi Jin, Tuo Wang, Zhihao Chen, Junwei Tang, Yifei Feng, Xiaowei Wang, Yueming Sun   +12 more
wiley   +1 more source

Repurposing a Small Molecule Plant Hormone as a Tunable ON‐Switch for CAR‐T Cell Immunotherapy

Advanced Science, EarlyView.
By engineering a receptor system integrating the plant auxin receptor AFB1 with its co‐receptor IAA7, we enable ligand‐dependent interactions triggered by the plant hormone auxins. This design allows rapid, reversible, and dose‐dependent T cell activation, resulting in potent cytotoxicity against B‐cell lymphoma in vitro and in vivo.
Hongxiang Zeng, Lei Zheng, Rongkun Tao, Sirui Zheng, Yanke Zhong, Yongxia Niu, Peng Zhang, Xiang Ma, Chen Yang, Min Zhang, Fuyu Duan, Jing Yang, Xuan Wei, Xiang Zhou, Zhenbiao Yang, Zhaoxi Sun, Qizhou Lian   +16 more
wiley   +1 more source

UENF Red: Agronomic potential and advantages of the new guava cultivar

Crop Breeding and Applied Biotechnology
The UENF Red guava cultivar was developed for the climate of northern Rio de Janeiro. Selected from 17 full-sib families, it showed superior yield and fruit quality compared to Paluma. Distinct morphological traits highlight its potential as a productive,
Alexandre Pio Viana, Messias Pereira Gonzaga, Antonio Teixeira do Amaral Jr., Flavia Alves da Silva, Silvana Silva Red Quintal, Natan Ramos Cavalcante, Bianca Machado Campos, Carlos Misael Bezerra de Sousa, Claudia Almeida Lougon, Fernando Henrique de Barros Walter, Nilmária Natália Vera Reis   +10 more
doaj  

GWAS‐assisted genomic selection for achieving high‐precision early sex prediction in Populus deltoides

The Plant Genome
Poplar (Populus spp.) breeding programs increasingly prioritize the development of male varieties due to the environmental issues caused by female catkins.
Xinglu Zhou, Min Zhang, Lei Zhang, Jianjun Hu   +3 more
doaj   +1 more source

Biochemically Constrained Multi‐Omics Integration Reveals Protein–Metabolite Dependencies Across Diseases

Advanced Science, EarlyView.
ProMetNet introduces a biologically constrained deep learning framework for proteo‐metabolomic integration by embedding Reactome‐derived pathway topology into neural networks. It captures non‐linear molecular dependencies and pathway‐level metabolic reorganization, enabling interpretable discrimination.
Minghui Zhao, Na Zhou, Ruotong Liu, Xiaofei Li, Jian Li, Fuzhong Xue, Qingzhen Hou   +6 more
wiley   +1 more source

Bulk vegetative propagation of Douglas fir (Pseudotsuga menziesii) full-sib families

, 1996
Bulk vegetative propagation of Douglas fir (Pseudotsuga menziesii) full-sib families. Vegetative propagation of elite full-sib families is one of the most promising means to obtain high genetic value material for intensive forestry. In France, selection for vegetative propagation ability would be necessary for operational production of cuttings from ...
Schermann, Nicolas, Verger, Michel, Bastien, Jean-Charles   +2 more
openaire   +1 more source