Results 91 to 100 of about 8,764 (251)

Comparative evaluation of phenotypic, pedigree, and family-based selection in insect breeding using stochastic simulation

Animal
Selective breeding in insects has predominantly relied on phenotypic selection without considering relatedness. Selection on estimated breeding values could potentially increase genetic gain, but the challenge of pedigree tracking complicates this ...
L.S. Hansen, A.C. Bouwman, G. Sahana, M. Slagboom, H.M. Nielsen, E.D. Ellen   +5 more
doaj   +1 more source

Selection between and within full-sib sugarcane families using the modified BLUPIS method (BLUPISM)

Genetics and Molecular Research, 2016
The objective of this study was to assess the efficiency of a modification of the simulated individual best linear unbiased prediction (BLUPIS) procedure, which is used for the approximation of classic individuals (BLUPI) for selection between and within sugarcane families.
R D, Castro, L A, Peternelli, M D V, Resende, C D, Marinho, P M A, Costa, M H P, Barbosa, E F A, Moreira   +6 more
openaire   +2 more sources

NAD+ Metabolism Licenses Zygotic Genome Activation via PARP7‐Mediated ADP‐Ribosylation of UHRF1 in Mouse Early Embryos

Advanced Science, EarlyView.
This study uncovers a metabolic‐epigenetic axis licensing zygotic genome activation (ZGA) in mouse embryos. A developmental decline in NAD+ levels activates PARP7, which mono‐ADP‐ribosylates and stabilizes UHRF1. This modification promotes the establishment of permissive histone acetylation marks, thereby facilitating timely ZGA.
Guangyi Cao, Ziqi Zhang, Anqi Chen, Yanbo Liu, Yuling Lin, Lina Yu, Ruixin Shi, Aolei Guo, Yan Mao, Ganggui Lou, Chaojun Li, Luhong Wen, Guijun Yan, Haixiang Sun   +13 more
wiley   +1 more source

Inhibition of KDEL Receptors Remodels the Tumor Microenvironment for T Cell Independent Tumor Regression

Advanced Science, EarlyView.
Inhibition of KDELR2 in a small fraction of tumor cells generates sustainable immunogenic cell death conditions within the tumor microenvironment. These conditions promote the regression of tumors in a T cell independent manner. During regression, macrophages prime T cells that subsequently provide systemic protection against recurrence. The potency of
Shakti P Pattanayak, Hong Wang, Belinda Willard, Timothy A. Chan, William C Merrick, Zheng‐Rong Lu, Boaz Tirosh   +6 more
wiley   +1 more source

‘UENF 506-11’: a new maize cultivar for the North and Northwest of Rio de Janeiro State

Crop Breeding and Applied Biotechnology, 2019
The intervarietal hybrid ‘UENF 506-11’ was derived from full-sib maize families in the 11th cycle of reciprocal recurrent selection. It produces a grain yield of 7.57 tons ha-1, and is recommended for cultivation in the North and Northwest regions of the
Julio Cesar Fiorio Vettorazzi, Messias Gonzaga Pereira, Ana Paula Candido Gabriel Berilli, Roberto dos Santos Trindade, Geovana Cremonini Entringer, Pedro Henrique Araújo Diniz Santos, Keila Silva da Cunha Galvão   +6 more
doaj  

Correlações entre caracteres agronômicos em dois ciclos de seleção recorrente em milho-pipoca Correlations among agronomic traits in two recurrent selection cycles in popcorn

Ciência Rural, 2004
Com o propósito de monitorar o comportamento de blocos gênicos em diferentes gerações de seleção recorrente em milho pipoca, quantificaram-se as correlações fenotípica, genotípica e de ambiente entre caracteres agronômicos, em dois ciclos de seleção ...
Máskio Daros, Antonio Teixeira do Amaral Júnior, Messias Gonzaga Pereira, Fabrício Santana Santos, Carlos Alberto Scapim, Silvério de Paiva Freitas Júnior, Rogério Figueiredo Daher, Marizangela Rizzatti Ávila   +7 more
doaj   +1 more source

De Novo Designed Minibinders Targeting the GDF15–GFRAL Axis Reverse Cancer Cachexia and Restore Anti‐Tumor Immunity

Advanced Science, EarlyView.
Tumor‐derived GDF15 drives cancer cachexia and suppresses antitumor immunity. Here, de novo designed minibinders targeting the GDF15–GFRAL interface achieve picomolar affinity and potent pathway blockade. The minibinders alleviate cachexia, restore CD8+ T‐cell infiltration, enhance anti–PD‐1 responsiveness, and provide survival benefits across tumor ...
Haitao Wang, Tianzhen Hua, Meiling Wang, Bingbing Meng, Yue Zhang, Chengxu Jiang, Yunhe Gao, Hongqi Yang, Jian Bo   +8 more
wiley   +1 more source

Análisis de polimorfismo de nucleótido simple en el gen FASN y su relación con características de producción en pollos [PDF]

RIA: Revista Investigaciones Agropecuarias, 2013
The purpose of this work is to evaluate possible associations between a Single Nucleotide Polymorphism(SNP) of FASN gene and each of the following productive traits: Feed Intake (FI), Weight Gain (WG) and FinalBody Weight (FBW). At the National Institute
MARRUBE, G., ROZEN, F.M.B., PINTO, G.B., FASSA, V., PACIENZA, N., DEMARCO, A.N, ROMANO, E.G., FAIN BINDA, V, CANET, Z., MELO, J.E   +9 more
doaj  

The KIF6‐RBP Complex Orchestrates mRNA Transport Required for Sperm Flagellar Assembly

Advanced Science, EarlyView.
Two homozygous deleterious KIF6 variants are identified in unrelated men with impaired sperm motility. Mouse models and multi‐omics analyses reveal that KIF6 cooperates with the RNA‐binding proteins FMRP and FXR1 to deliver mRNAs essential for sperm flagellar assembly, linking disrupted mRNA transport to reduced abundance of key structural and ...
Chunbo Xie, Sibing Yi, Xinle Lin, Shen Zhang, Weili Wang, Shimin Yuan, Lanlan Meng, Yong Li, Chen Tan, Chunjia Wei, Yanyan Yu, Yaoqiong Liang, Huan Zhang, Liang Hu, Guangxiu Lu, Wenbin He, Qianjun Zhang, Juan Du, Ge Lin, Chaofeng Tu, Yue‐Qiu Tan   +20 more
wiley   +1 more source

eEF1G Orchestrates Translation to Ensure Meiotic Progression in Transcriptionally Quiescent Spermatocytes

Advanced Science, EarlyView.
eEF1G supports translation elongation of meiotic mRNAs in transcriptionally quiescent leptotene and zygotene spermatocytes. Its depletion in germ cells causes meiotic arrest at the zygotene stage, with defective homologous synapsis and unstable recombination intermediates.
Jianze Xu, Yuwei Hu, Xukun Lu, Yuling Cai, Tongtong Li, Ming Gao, Jinlong Ma, Yuan Gao, Shangming Liu, Zi‐Jiang Chen, Jing Meng, Hongbin Liu, Xiaohua Jiang   +12 more
wiley   +1 more source