Results 121 to 130 of about 1,492,497 (311)

Modal Analysis of Marine Pipeline Based on Full-scale Fatigue Test System

Shiyou jixie, 2018
In the past, the full-scale fatigue tests of marine pipelines were mostly focused on the bending fatigue. Considering the uneven circumferential force on the pipeline weld and the prolonged test period, the resonance principle is proposed for the fatigue
Liang Ke, Hu Yanhua, Tang Deyu, Fan Jianchun, Zhang Zhiyuan   +4 more
doaj  

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Cold-formed steel portal frames in fire: Full-scale testing and finite element analysis

, 2014
A full-scale, non-uniform natural fire test on a cold-formed steel portal frame building is described. The results of the test are used to validate a non-linear, elasto-plastic, finite element shell idealisation, for the purposes of later forming the ...
Armstrong, Prof. C. G., Mei, C., Sonebi, M., Switzer, C., Xu, Y., Amstrong, C., Lim, James, Lim, James B. P., Sonebi, Mohammed; id_orcid, Switzer, Y., Lau, H. H., Lim, J., Sonebi, Mohamed; id_orcid, Johnston, Ross P. D., Xu, H., Johnston, R., Lau, Hieng Ho, Sweitzer, C., Armstrong, C., Mei, C. C., Lau, H.   +20 more
core  

Research of Weight Deduction in Full-scale Aircraft Static Strength Test

, 2015
Weight deduction is one of the key steps in full-scale aircraft static strength test. It will keep the experimental craft zero-gravity during the full-scale aircraft static strength test and fatigue strength test to make the test status as real flight ...
lei, Zhang, feng, Xia, bing, Liu
core   +1 more source

High-Temperature Fatigue Testing of Turbine Blades

Fatigue of Aircraft Structures
This paper evaluates the efficacy of a patented grip for high-temperature fatigue testing by establishing the S-N curve for full-scale nickel-based turbine blades under simulated environmental conditions.
Kopec Mateusz, Kukla Dominik, Wyszkowski Mirosław, Kowalewski Zbigniew L.   +3 more
doaj   +1 more source

Flexural behavior of shield tunnel lining segments reinforced using grouted channel steel: Experimental investigation

Case Studies in Construction Materials
This study examines a reinforcement method using grouted channel steel for damaged shield tunnel lining segments in urban rail transit systems. Full-scale experiments were conducted to analyze the flexural failure mechanism and evaluate the performance ...
Kan Huang, Xun Wu, Jun He, Bin Huang, Yi Peng, Kaidi Zhou   +5 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Full-Scale Flight Test

, 2007
This viewgraph presentation reviews full-scale flight tests of the F/15 837 and F/A-18 853 aircrafts.
Bosworth, John T.
core  

Barrier Management Scale in Physical Exercise]

, 2012
Die Skala SBBM erfasst konkrete Strategien, die Individuen einsetzen können, um die einmal gefasste Verhaltensabsicht, Sport zu treiben, gegenüber auftretenden Barrieren abzuschirmen und in Verhalten umzusetzen.
Krämer, L., Fuchs, R.
core   +1 more source