Results 111 to 120 of about 1,492,497 (311)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Full-scale tests of deicing with seawater

open access: yesCold Regions Science and Technology
Sea-spray icing is one of the major hazards for small- and medium-sized vessels in polar regions. Predominant anti- and deicing measures include prevention by heeding the weather forecasts and avoiding high-risk situations, protection by enclosing exposed and high-priority areas, manual ice removal by personnel, heat tracing and surplus heat. Energy is
Sæterdal, Ane Solbakken   +1 more
openaire   +2 more sources

Assessing the Impact of Characteristics of the Test, Common-items, and Examinees on the Preservation of Equity Properties in Mixed-format Test Equating [PDF]

open access: yes, 2014
Preservation of equity properties was examined using four equating methods - IRT True Score, IRT Observed Score, Frequency Estimation, and Chained Equipercentile - in a mixed-format test under a common-item nonequivalent groups (CINEG) design.
Wolf, Raffaela
core  

ZL-130TCII Fracture Markers Solution for Full-Scale Fatigue Test

open access: yes, 2011
ZL-130TCII Fracture Markers Solution for Full-Scale Fatigue TestIn the context of PZL-130TC-II full-scale fatigue test, several strategies of fatigue loadings that create fracture surface markings were considered.
Sylwester Kłysz   +9 more
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Test of a Full Scale Roof Truss

open access: yes, 1992
In order to obtain information of ultimate capacity and destructive characteristics of a roof truss, the test of a full scale roof truss was carried out based on the test results this article has analysed the destructive mechanism and presented the ...
Guo, Yao - Jie, Fang, Shan-Feng
core  

Eemdijk full-scale field test programme: sheet pile pullover tests (TProgramme d’essai terrain à taille réelle Eemdijk: essais de déformation et de rupture de murs palplanches)

open access: yes, 2019
Dikes in the Netherlands have traditionally been constructed with soil. Climate change and sub-sidence requires heightening and or reinforcing of these existing ground dikes.
Breedeveld, J. (author)   +3 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

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