Results 91 to 100 of about 4,551,617 (315)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Experimental Study on Sealing Failure of Cement Sheath in Gas Storage Wells
Shiyou jixieCyclic injection and production of gas would cause cyclic loads on the cement sheath of gas storage wells,which can easily lead to the sealing failure of cement sheath.In the paper,against the background of sealing failure of cement sheath in H gas ...
Zhao Chun +6 more
doaj
Full-Scale Pseudo-Dynamic Test for Bridge Retrofitted With Seismic Isolations
The Baltic Journal of Road and Bridge Engineering, 2008 This paper presents the performance of a retrofitted bridge with a seismic isolation. To validate the seismic performance of retrofitted bridge experimentally, four full-scale reinforced concrete bridge piers with fixed support conditions were fabricated
Kyoung-Bong Han +2 more
doaj
An analysis of performance estimation methods for aircraft [PDF]
Measurements and analytical extrapolation validity in predicting full scale flight performance from model wind tunnel ...
Brown, C. E., Chen, C. F.
core +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Full-scale aircraft cabin flammability tests of improved fire-resistant materials, test series 2 [PDF]
Full-scale aircraft flammability tests in which the effectiveness of new fire-resistant materials was evaluated by comparing their burning characteristics with those of other fire-resistant aircraft materials were described.
Bricker, R. W. +3 more
core +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Solid Polymer Electrolyte Fuel Cell Technology Program [PDF]
Work is reported on phase 5 of the Solid Polymer Electrolyte (SPE) Fuel Cell Technology Development program. The SPE fuel cell life and performance was established at temperatures, pressures, and current densities significantly higher than those ...
core +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source